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Accurate detection of the formation of carboxyhemoglobin (COHb) in the blood is very important for the identification of CO poisoning. In this review, the effects of exogenous toxins, including dichloromethane (DCM), nitrite, and hydrogen sulfide, on the determination of COHb by spectrophotometry are summarized by comparing epidemiological data, case studies, and analytical methods. The mechanism of the effects of these exogenous poisons on COHb detection is described, and the extent of their influence on the clinical diagnosis and forensic identification of CO poisoning is discussed. We suggest that emergency medicine and forensic science practices need to improve the understanding of these toxins and optimize clinical diagnosis and evaluation strategies to address the effects of toxins on the determination of COHb.<\/jats:p>","DOI":"10.1093\/jat\/bkae096","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T08:53:48Z","timestamp":1734425628000},"page":"170-179","source":"Crossref","is-referenced-by-count":2,"title":["Effects of dichloromethane, nitrate, and sulfhemoglobin-induced substances on carboxyhemoglobin detection: a comprehensive review"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3030-0676","authenticated-orcid":false,"given":"Jialin","family":"Wu","sequence":"first","affiliation":[{"name":"Shanghai Key Lab of Forensic Medicine, Key Lab of Forensic Science, Ministry of Justice , Shanghai 200063,","place":["China"]},{"name":"Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University , Shanghai 200032,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujing","family":"Luan","sequence":"additional","affiliation":[{"name":"Institute of Forensic Science, Ministry of Public Security , Beijing 100038,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, China-Japan Friendship Hospital , Beijing 100029,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanglin","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Forensic Science, Ministry of Public Security , Beijing 100038,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulan","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University , 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