{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:11:31Z","timestamp":1790183491303,"version":"4.1.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alcohol is the most abused substance in Western society, resulting in major economic losses and negative health consequences. Therefore, there is a need for a selective and robust detection method for alcohol consumption in various clinical and forensic settings. This study aimed to validate a mass spectrometry method for quantifying phosphatidylethanol (PEth) and perform retrospective data analysis from the patient population of a national reference laboratory. Quantification of PEth in whole blood was accomplished using an LC\u2013MS-MS assay. Isotopically labeled internal standard for the two PEth homologues was added to the whole-blood specimen, followed by protein precipitation with a mixture of acetonitrile and isopropyl alcohol. After centrifugation, an aliquot of the supernatant was buffered with ammonium acetate before LC\u2013MS\u2013MS analysis on an Agilent 6470 triple quadrupole mass spectrometer coupled to an Agilent 1260 Infinity II LC system. This LC\u2013MS-MS assay was validated for clinical use in accordance with Clinical &amp; Laboratory Standards Institute guidelines. The analytical measurement range, 10\u20132000\u2009ng\/mL, was linear with R2 of 0.999. The within-run and total imprecision was\u2009&amp;lt;\u20095% CV for the low (20\u2009ng\/mL), medium (200\u2009ng\/mL), and high QC (1000\u2009ng\/mL). Results from accuracy and method comparison experiments met the bias criteria of \u00b115%. Retrospective data analysis showed \u223c27% of patients had PEth concentrations &amp;lt;20\u2009ng\/mL. Males and females had similar positivity rates for PEth and the positivity rate of women of reproductive age (15\u201344\u2009years old) was 35% in comparison to 25% in women 45\u201389\u2009years old. This study\u2019s LC\u2013MS-MS method showed acceptable analytical performance in quantifying PEth as a sensitive and specific biomarker for evaluating alcohol consumption. Results from this study may provide an opportunity to educate women of reproductive age on drinking during pregnancy and the long-term effects of alcohol use.<\/jats:p>","DOI":"10.1093\/jat\/bkae100","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T20:31:27Z","timestamp":1735331487000},"page":"191-200","source":"Crossref","is-referenced-by-count":7,"title":["Beyond the baseline: quantification of two phosphatidylethanol homologues in whole blood by LC\u2013MS-MS and retrospective data analysis from a National Reference Laboratory"],"prefix":"10.1093","volume":"49","author":[{"given":"Nicole J","family":"Mathewson","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Utah Health , Salt Lake City, UT 84108,","place":["USA"]},{"name":"ARUP Laboratories, ARUP Institute for Clinical and Experimental Pathology , Salt Lake City, UT 84108,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nkemakonam C","family":"Okoye","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Northwell Health , New Hyde Park, NY 11042,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-2923","authenticated-orcid":false,"given":"Heather A","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah Health , Salt Lake City, UT 84108,","place":["USA"]},{"name":"ARUP Laboratories, ARUP Institute for Clinical and Experimental Pathology , Salt Lake City, UT 84108,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vrajesh","family":"Pandya","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah Health , Salt Lake City, UT 84108,","place":["USA"]},{"name":"ARUP Laboratories, ARUP Institute for Clinical and Experimental Pathology , Salt Lake City, UT 84108,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Moore","sequence":"additional","affiliation":[{"name":"Sports Medicine Research and Testing Laboratory , Salt Lake City, UT 84108,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7943-6784","authenticated-orcid":false,"given":"Kamisha L","family":"Johnson-Davis","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah Health , Salt Lake City, UT 84108,","place":["USA"]},{"name":"ARUP Laboratories, ARUP Institute for Clinical and Experimental Pathology , Salt Lake City, UT 84108,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"2025031016571812100_R1","article-title":"Key Substance Use and Mental Health Indicators in the 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