{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:10:17Z","timestamp":1778753417646,"version":"3.51.4"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Anti-drug Policies Department of the Italian Government Presidency of the Council of Ministers"},{"name":"Anti-drug Policies Department of the Italian Government Presidency of the Council of Ministers"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Synthetic cathinones (SCs) were confirmed as the second most prevalent class of New Psychoactive Substances (NPS) in 2024, underscoring their widespread availability and use. Notably, the SCs seizure and related intoxication cases increased within the European Union, involving mostly 3-chloromethcathinone, 3-methylmethcathinone, 2-methylmethcathinone, and N-ethylnorpentedrone. Italy has observed a distinct trend, with methylendioxy pyrrolidinohexanophenone (MDPHP) emerging as a significant concern. This technical note aims to provide a comparative analysis of the most recent data concerning the emergence and the spread of MDPHP in Italy. Data from the National Early Warning System on Drugs indicate that the total amount of seized MDPHP increased from 2021 to 2024. In 2023, MDPHP-related intoxication cases peaked at 47, considering either alone or in combination with other drugs, followed by a slight decrease in 2024. In Italy, MDPHP seems to dominate the Italian black market of SCs and with two fatalities reported. This increased demand for MDPHP raises health concerns, indicating the necessity to enhance drug-related harm reduction services and improve a multidisciplinary network that provides data for understanding the complex phenomenon of NPS.<\/jats:p>","DOI":"10.1093\/jat\/bkaf024","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T05:46:52Z","timestamp":1742017612000},"page":"417-421","source":"Crossref","is-referenced-by-count":6,"title":["The rising trend of MDPHP consumption: an Italian snapshot"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0127-4225","authenticated-orcid":false,"given":"Nunzia","family":"La Maida","sequence":"first","affiliation":[{"name":"National Centre on Addiction and Doping, National Institute of Health , Rome 00161,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Aquilina","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Public Health, University \u201cPolitecnica delle Marche\u201d , Ancona 60126,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9256-4326","authenticated-orcid":false,"given":"Fabio","family":"Vaiano","sequence":"additional","affiliation":[{"name":"Laboratory of Forensic Toxicology FT-LAB, Department of Health Science, University of Florence , Firenze 50121,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Cavallo","sequence":"additional","affiliation":[{"name":"Central Directorate for Anti-Drug Services , Department of Public Security of the Ministry of the Interior, Rome 00173,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo Alessandro","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Toxicology Unit, Pavia Poison Centre and National Toxicology Information Centre, Laboratories of Clinical & Experimental Toxicology, IRCCS Istituti Clinici Scientifici Maugeri , Pavia 27100,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Mannaioni","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence , Florence 50121,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Arillotta","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence , Florence 50121,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6347-0750","authenticated-orcid":false,"given":"Simona","family":"Pichini","sequence":"additional","affiliation":[{"name":"National Centre on Addiction and Doping, 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