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A comprehensive optimization of the method was performed using a multivariate statistical approach, incorporating validation criteria in line with established practices for method validation in forensic toxicology. The method showed linearity between 1 and 200\u2009ng\/mL (r2\u2009&amp;gt;\u20090.990), with good imprecision (&amp;lt;9.8%) and inaccuracy (&amp;lt;11.1%) evaluated at three different quality control concentrations. Matrix effects and recovery rates were found to be better than 58% and 77.5%, respectively. No carryover or interferences were detected during the analysis. The method was effectively utilized on two real forensic postmortem blood samples, both of which tested positive for bromazolam, showing concentrations of 31 and 40\u2009ng\/mL. The micro-QuEChERS extraction method demonstrated satisfactory analytical performance and is an environmentally sustainable option, minimizing the use of solvents and reagents, with potential for application in both clinical and forensic analyses, aligning with green analytical toxicology principles.<\/jats:p>","DOI":"10.1093\/jat\/bkag008","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:37:43Z","timestamp":1770122263000},"source":"Crossref","is-referenced-by-count":1,"title":["Micro-QuEChERS extraction method optimization for quantification of designer benzodiazepines in forensic postmortem blood samples"],"prefix":"10.1093","volume":"50","author":[{"given":"Karla Aparecida de Oliveira","family":"Souza","sequence":"first","affiliation":[{"name":"Centro de Informa\u00e7\u00e3o e Assist\u00eancia Toxicol\u00f3gica de Campinas (CIATox-Campinas), Universidade Estadual de Campinas (UNICAMP) , Campinas, S\u00e3o Paulo, 13083-888,","place":["Brazil"]},{"name":"Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Estadual de Campinas (UNICAMP) , Campinas, S\u00e3o Paulo, 13083-888,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana\u00edna Aparecida Reis","family":"Teodoro","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Universidade Estadual de Campinas (UNICAMP) , Campinas, S\u00e3o Paulo, 13083-871,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Zorron","family":"Berlinck","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Universidade Estadual de Campinas (UNICAMP) , Campinas, S\u00e3o Paulo, 13083-871,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Knak","family":"Rezendes","sequence":"additional","affiliation":[{"name":"Forensic Toxicology Laboratory, Scientific Police of 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