{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:29:28Z","timestamp":1788798568909,"version":"build-2803163510"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alcohol and glycol ingestion, including substances such as methanol, ethylene glycol, and isopropanol, constitute a serious medical emergency that requires prompt diagnosis and treatment of patients. Rapid and accurate quantification of these compounds in plasma is essential to guide clinical decision-making and prevent delays in treatment that could result in irreversible organ damage or death. Many healthcare facilities lack analytical methods capable of simultaneously quantifying both alcohols and glycols in a single run. This study describes the development and validation of a rapid gas chromatography\u2013flame ionization detection (GC-FID) method for the simultaneous screening and quantification of methanol, ethanol, 2-propanol, acetone, ethylene glycol, diethylene glycol, 1,2-propylene glycol, and 1,3-propylene glycol in human plasma. Plasma samples were prepared using a protein precipitation technique with acetonitrile containing two internal standards: 2-butanol and 1,4-butanediol. Acetonitrile effectively precipitated plasma proteins. The supernatant was then subjected to GC-FID analysis for quantification of the target\u00a0al.ohols and glycols. The total analytical run time was 5\u2009minutes, enabling the quantification of eight analytes in a single injection. The method demonstrated excellent linearity, with correlation coefficients (R2) exceeding 0.9995 for all compounds. The linear dynamic range was 40\u20131280\u2009mg\/L for methanol, 2-propanol, acetone, ethylene glycol, diethylene glycol, 1,2-propylene glycol, and 1,3-propylene glycol, and 80\u20132560\u2009mg\/L for ethanol. Within-run and between-run precision and accuracy (CV and bias) for all analytes were within the predefined acceptance criteria of \u00b115%. No significant interference, carry-over, or matrix effects were observed, confirming the method\u2019s selectivity and robustness. The developed GC-FID method enables rapid, accurate, and simultaneous quantification of toxic alcohols and glycols in plasma within a 5-minute run time. The excellent linearity, precision, and selectivity of the method met\u00a0al. analytical performance criteria, making it well-suited for routine clinical use. This method provides a valuable tool for timely diagnosis and management of suspected toxic alcohol and glycol ingestions in patients in emergency settings.<\/jats:p>","DOI":"10.1093\/jat\/bkag013","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T12:31:46Z","timestamp":1770640306000},"source":"Crossref","is-referenced-by-count":1,"title":["GC-FID quantification of methanol, ethanol, 2-propanol, acetone, ethylene glycol, diethylene glycol, 1,2-propylene glycol and 1,3-propylene glycol in plasma"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8276-0860","authenticated-orcid":false,"given":"Mohsin","family":"El Amrani","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht University , Utrecht, 3508 GA,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan","family":"Zandbergen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht University , Utrecht, 3508 GA,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Groot","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht University , Utrecht, 3508 GA,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Bognar","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht University , Utrecht, 3508 GA,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin H","family":"Smeijsters","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht University , Utrecht, 3508 GA,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim C M","family":"van der Elst","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht University , Utrecht, 3508 GA,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"2026052302061125800_bkag013-B1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ajem.2023.01.048","article-title":"High risk and low prevalence diseases: 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