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Since antipsychotics primarily act within the central nervous system, brain tissue serves as an alternative or complementary matrix to femoral blood in toxicological analysis. This study aimed to retrospectively evaluate brain concentrations and brain-blood ratios across toxic and non-toxic levels in 466 postmortem cases involving chlorprothixene, clozapine, olanzapine, and\/or quetiapine. Median concentrations in brain tissue across all cases were 0.20\u2009mg\/kg for chlorprothixene, 4.2\u2009mg\/kg for clozapine, 0.42\u2009mg\/kg for olanzapine, and 0.34\u2009mg\/kg for quetiapine. Corresponding brain-blood ratios remained stable across the examined concentration range with median ratios of 3.1 for chlorprothixene, 2.9 for clozapine, 2.6 for olanzapine, and 3.0 for quetiapine. The provided brain concentrations and ratios can support further toxicological evaluations of postmortem cases.<\/jats:p>","DOI":"10.1093\/jat\/bkag065","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:46:16Z","timestamp":1784115976000},"source":"Crossref","is-referenced-by-count":0,"title":["From blood to brain: postmortem brain concentrations and brain\u2013blood ratios of chlorprothixene, clozapine, olanzapine, and quetiapine"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3987-6186","authenticated-orcid":false,"given":"Mikayla Z","family":"van der Meer","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Forensic Medicine, University of Copenhagen , Copenhagen, DK 2100,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8048-3222","authenticated-orcid":false,"given":"Brian 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