{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T04:26:29Z","timestamp":1794025589102,"version":"4.8.0"},"reference-count":4,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chang et\u00a0al. report substantial variability in fentanyl blood-to-brain relationships and suggest that brain testing may be beneficial in suspected overdose cases with low peripheral blood concentrations. We suggest that this implication would be strengthened by distinguishing analytical confirmation from incremental forensic interpretation. Demonstrating fentanyl in a second matrix does not itself establish that the brain result changes attribution of fentanyl\u2019s role in death. A focused analysis of low-blood cases in which brain findings altered interpretation, supported by scene, autopsy, and co-intoxicant data, would better define the practical value of brain testing.<\/jats:p>","DOI":"10.1093\/jat\/bkag088","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:47:04Z","timestamp":1791546424000},"source":"Crossref","is-referenced-by-count":0,"title":["Comment on Chang et al.: defining the added interpretive value of brain fentanyl testing at low blood concentrations"],"prefix":"10.1093","volume":"50","author":[{"given":"Ercan","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy and Immunology, Inonu University Faculty of Medicine , Malatya,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6910-5463","authenticated-orcid":false,"given":"Zeynep","family":"Yamancan Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Inonu University Faculty of Medicine , Malatya,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,10]]},"reference":[{"key":"2026110623063706300_bkag088-B1","doi-asserted-by":"publisher","first-page":"bkag051","DOI":"10.1093\/jat\/bkag051","article-title":"Fentanyl concentrations for peripheral blood and brain samples in non-medical postmortem cases","volume":"50","author":"Chang","year":"2026","journal-title":"J Anal Toxicol"},{"key":"2026110623063706300_bkag088-B2","doi-asserted-by":"publisher","first-page":"bkag068","DOI":"10.1093\/jat\/bkag068","article-title":"Occipital lobe to femoral blood ratios of amphetamine, methamphetamine, cocaine, benzoylecgonine, cocaethylene, and fentanyl in postmortem cases","volume":"50","author":"Behnke","year":"2026","journal-title":"J Anal Toxicol"},{"key":"2026110623063706300_bkag088-B3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1093\/jat\/bkaa048","article-title":"Postmortem brain-blood ratios of codeine, fentanyl, oxycodone and tramadol","volume":"45","author":"Nedahl","year":"2021","journal-title":"J Anal Toxicol"},{"key":"2026110623063706300_bkag088-B4","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s13181-012-0253-z","article-title":"Reliability of postmortem fentanyl concentrations in determining the cause of death","volume":"9","author":"Gill","year":"2013","journal-title":"J Med Toxicol"}],"container-title":["Journal of Analytical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jat\/advance-article-pdf\/doi\/10.1093\/jat\/bkag088\/71837726\/bkag088.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jat\/article-pdf\/50\/9\/bkag088\/71837726\/bkag088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jat\/article-pdf\/50\/9\/bkag088\/71837726\/bkag088.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T04:06:42Z","timestamp":1794024402000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jat\/article\/doi\/10.1093\/jat\/bkag088\/8907270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":4,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9,26]]}},"URL":"https:\/\/doi.org\/10.1093\/jat\/bkag088","relation":{},"ISSN":["1945-2403"],"issn-type":[{"value":"1945-2403","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,9]]},"article-number":"bkag088"}}