{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:28:08Z","timestamp":1789140488627,"version":"build-2803163510"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1093\/jat\/bkx019","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T15:12:49Z","timestamp":1487689969000},"page":"441-450","source":"Crossref","is-referenced-by-count":34,"title":["Validated Method for the Screening and Quantification of Baclofen, Gabapentin and Pregabalin in Human Post-Mortem Whole Blood Using Protein Precipitation and Liquid Chromatography\u2013Tandem Mass Spectrometry"],"prefix":"10.1093","volume":"41","author":[{"given":"Limon","family":"Nahar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Paterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,10]]},"reference":[{"key":"key\n\t\t\t\t20170512084105_bkx019C1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1136\/jnnp.33.4.464","article-title":"A new agent for the control of spasticity","volume":"33","year":"1970","journal-title":"Journal of Neurology, Neurosurgery & Psychiatry"},{"key":"key\n\t\t\t\t20170512084105_bkx019C2","first-page":"1","article-title":"A decade of gabapentinoid misuse: an analysis of the European medicines agency's \u2018suspected adverse drug reactions\u2019 database","volume":"30","year":"2016","journal-title":"CNS Drugs"},{"key":"key\n\t\t\t\t20170512084105_bkx019C3","author":"Prescription Cost Analysis England 2009.","year":"2010"},{"key":"key\n\t\t\t\t20170512084105_bkx019C4","author":"Prescription Cost Analysis England 2015.","year":"2016"},{"key":"key\n\t\t\t\t20170512084105_bkx019C5","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/bcp.12277","article-title":"Misuse of the \u03b3-aminobutyric acid analogues baclofen, gabapentin and pregabalin in the UK","volume":"78","year":"2014","journal-title":"British Journal of Clinical Pharmacology"},{"key":"key\n\t\t\t\t20170512084105_bkx019C6","author":"Advice for prescribers on the risk of the misuse of pregabalin and gabapentin.","year":"2013"},{"key":"key\n\t\t\t\t20170512084105_bkx019C7","first-page":"372","article-title":"Emergency Department presentations following recreational use of baclofen, gabapentin and pregabalin: a Euro-DEN case series","volume":"53","year":"2015","journal-title":"Clinical Toxicology"},{"key":"key\n\t\t\t\t20170512084105_bkx019C8","first-page":"376","article-title":"Pregabalin, gabapentin and baclofen: Sources of drug acquisition for non-medical use in an online national survey in the UK","volume":"53","year":"2015","journal-title":"Clinical Toxicology"},{"key":"key\n\t\t\t\t20170512084105_bkx019C9","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1007\/s00228-013-1578-5","article-title":"Pregabalin abuse among opiate addicted patients","volume":"69","year":"2013","journal-title":"European Journal of Clinical Pharmacology"},{"key":"key\n\t\t\t\t20170512084105_bkx019C10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.forsciint.2016.05.033","article-title":"Pregabalin concentrations in post-mortem blood\u2014a two year study","volume":"266","year":"2016","journal-title":"Forensic Science International"},{"key":"key\n\t\t\t\t20170512084105_bkx019C11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/jat\/bkv125","article-title":"Validated method for the quantification of baclofen in human plasma using solid-phase extraction and liquid chromatography\u2013tandem mass spectrometry","volume":"40","year":"2016","journal-title":"Journal of Analytical Toxicology"},{"key":"key\n\t\t\t\t20170512084105_bkx019C12","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/j.1528-1167.2008.01561.x","article-title":"Antiepileptic drugs\u2014best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies","volume":"49","year":"2008","journal-title":"Epilepsia"},{"key":"key\n\t\t\t\t20170512084105_bkx019C13","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/01.ftd.0000158874.54100.1a","article-title":"Analysis of pregabalin at therapeutic concentrations in human plasma\/serum by reversed-phase HPLC","volume":"27","year":"2005","journal-title":"Therapeutic Drug Monitoring"},{"key":"key\n\t\t\t\t20170512084105_bkx019C14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0378-4347(85)80047-5","article-title":"High-performance liquid chromatographic analysis of baclofen in plasma and urine of man after precolumn extraction and derivatization with o-phthaldialdehyde","volume":"337","year":"1985","journal-title":"Journal of Chromatography"},{"key":"key\n\t\t\t\t20170512084105_bkx019C15","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0378-4347(00)84675-7","article-title":"Determination of 4-amino-3-(p-chlorophenyl) butyric acid (baclofen) in plasma by high-performance liquid chromatography","volume":"339","year":"1985","journal-title":"Journal of Chromatography B: Biomedical Sciences and Applications"},{"key":"key\n\t\t\t\t20170512084105_bkx019C16","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jpba.2006.05.012","article-title":"Determination of gabapentin in human plasma and urine by high-performance liquid chromatography with UV\u2013Vis detection","volume":"42","year":"2006","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"key\n\t\t\t\t20170512084105_bkx019C17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0379-0738(01)00512-6","article-title":"Death due to baclofen and dipyrone ingestion","volume":"123","year":"2001","journal-title":"Forensic Science International"},{"key":"key\n\t\t\t\t20170512084105_bkx019C18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jat\/23.1.1","article-title":"Analysis of gabapentin in serum and plasma by solid-phase extraction and gas chromatography-mass spectrometry for therapeutic drug monitoring","volume":"23","year":"1999","journal-title":"Journal of Analytical Toxicology"},{"key":"key\n\t\t\t\t20170512084105_bkx019C19","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jpba.2012.05.001","article-title":"Development, validation and comparison of two microextraction techniques for the rapid and sensitive determination of pregabalin in urine and pharmaceutical formulations after ethyl chloroformate derivatization followed by gas chromatography\u2013mass spectrometric analysis","volume":"70","year":"2012","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"key\n\t\t\t\t20170512084105_bkx019C20","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jpba.2005.07.012","article-title":"Rapid quantification of gabapentin in human plasma by liquid chromatography\/tandem mass spectrometry","volume":"40","year":"2006","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"key\n\t\t\t\t20170512084105_bkx019C21","doi-asserted-by":"crossref","first-page":"354","DOI":"10.4103\/0110-5558.72423","article-title":"Determination of pregabalin in human plasma by electrospray ionisation tandem mass spectroscopy","volume":"1","year":"2010","journal-title":"Journal of Advanced Pharmaceutical Technology & Research"},{"key":"key\n\t\t\t\t20170512084105_bkx019C22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/jat\/bku010","article-title":"Determination of therapeutic \u03b3-aminobutyric acid analogs in forensic whole blood by hydrophilic interaction liquid chromatography\u2013electrospray tandem mass spectrometry","volume":"38","year":"2014","journal-title":"Journal of Analytical Toxicology"},{"key":"key\n\t\t\t\t20170512084105_bkx019C23","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jchromb.2014.05.030","article-title":"Simultaneous determination of gabapentin, pregabalin, vigabatrin, and topiramate in plasma by HPLC with fluorescence detection","volume":"962","year":"2014","journal-title":"Journal of Chromatography B"},{"key":"key\n\t\t\t\t20170512084105_bkx019C24","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/jat\/bku070","article-title":"Simultaneous analysis of 22 antiepileptic drugs in postmortem blood, serum and plasma using LC-MS-MS with a focus on their role in forensic cases","volume":"38","year":"2014","journal-title":"Journal of Analytical Toxicology"},{"key":"key\n\t\t\t\t20170512084105_bkx019C25","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.jpba.2011.07.019","article-title":"Simple and accurate quantitative analysis of ten antiepileptic drugs in human plasma by liquid chromatography\/tandem mass spectrometry","volume":"56","year":"2011","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"key\n\t\t\t\t20170512084105_bkx019C26","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/chromsci\/48.5.358","article-title":"A new pre-column derivatization method for determination of gabapentin in human serum by HPLC using UV detection","volume":"48","year":"2010","journal-title":"Journal of Chromatographic Science"},{"key":"key\n\t\t\t\t20170512084105_bkx019C27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/jat\/bku004","article-title":"Quantification of pregabalin using hydrophilic interaction HPLC-high-resolution MS in postmortem human samples: eighteen case reports","volume":"38","year":"2014","journal-title":"Journal of Analytical Toxicology"},{"key":"key\n\t\t\t\t20170512084105_bkx019C28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jpba.2015.02.023","article-title":"Quantitation of pregabalin in dried blood spots and dried plasma spots by validated LC\u2013MS\/MS methods","volume":"109","year":"2015","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"key\n\t\t\t\t20170512084105_bkx019C29","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0021-9673(99)00013-8","article-title":"Sensitive method for the determination of baclofen in plasma by means of solid-phase extraction and liquid chromatography\u2013tandem mass spectrometry","volume":"846","year":"1999","journal-title":"Journal of Chromatography A"},{"key":"key\n\t\t\t\t20170512084105_bkx019C30","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.scijus.2010.09.005","article-title":"The United Kingdom and Ireland Association of Forensic Toxicologists: forensic toxicology laboratory guidelines (2010)","volume":"50","year":"2010","journal-title":"Science & Justice"},{"key":"key\n\t\t\t\t20170512084105_bkx019C31","first-page":"534","article-title":"Calibration curves, part V: curve weighting","volume":"27","year":"2009","journal-title":"LCGC North America"},{"key":"key\n\t\t\t\t20170512084105_bkx019C32","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/dta.1733","article-title":"Determination of a selection of anti-epileptic drugs and two active metabolites in whole blood by reversed phase UPLC-MS\/MS and some examples of application of the method in forensic toxicology cases","volume":"7","year":"2015","journal-title":"Drug Testing and Analysis"}],"container-title":["Journal of Analytical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jat\/article-pdf\/41\/5\/441\/16982796\/bkx019.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T15:44:29Z","timestamp":1503589469000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jat\/article-lookup\/doi\/10.1093\/jat\/bkx019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,10]]},"references-count":32,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,3,10]]},"published-print":{"date-parts":[[2017,6]]}},"URL":"https:\/\/doi.org\/10.1093\/jat\/bkx019","relation":{},"ISSN":["0146-4760","1945-2403"],"issn-type":[{"value":"0146-4760","type":"print"},{"value":"1945-2403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,10]]}}}