{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T20:40:26Z","timestamp":1721853626626},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,3,16]],"date-time":"2019-03-16T00:00:00Z","timestamp":1552694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A 38-year-old man was admitted in the intensive care unit (ICU) after supposed ingestion of 504 sustained-release tablets of Theralithe\u2122 corresponding ~200 g of lithium carbonate. At the admission, ~19.5 h after ingestion, the patient was conscious with trembling limbs, intense thirst, profuse sweats and vomiting and lithium serum concentration was 14.2 mmol\/L. Toxicological screenings performed in urine and serum, were negative. Patient was treated with continuous extrarenal epuration by continue veno-venous hemodiafiltration starting (CCVHDF) 24 h post-admission and was carried on until 64 h. After 11 days in ICU, the patient was dismissed to the service without sequelae, and transferred to a psychiatric unit. To follow lithium concentrations in serum, urines and dialysates, we developed a simple, rapid and reliable method by capillary zone electrophoresis (CZE). Separation was achieved in 7 min. The method was linear between 0.14 and 1.44 mmol\/L for serum samples, and between 0.07 and to 1.44 mmol\/L for urines and dialysates. Limits of quantification were 0.15 mmol\/L and 0.07 mmol\/L for serum and others fluids, respectively. Intra- and inter-day precisions expressed as CV were systematically inferior to 12.1% for serum and 8.2% for other fluids. Results obtained regarding precision, accuracy, recovery and stability were satisfying, with recoveries ranging from 91.0 to 102.0%. Serum, urine and dialysate samples were measured using CZE and flame photometry. We observed a strong correlation between both methods as assessed by linear regression and Bland\u2013Altman analysis. For the intoxicated patient, the assay was successfully applied to serum, urine and dialysates to determine the amount of lithium present in circulation and excreted. Lithium amounts in dialysates were estimated to correspond to 89% of total lithium excreted during CCVHF session while urine excretion account only for 11%.<\/jats:p>","DOI":"10.1093\/jat\/bkz013","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T20:45:02Z","timestamp":1550695502000},"page":"571-578","source":"Crossref","is-referenced-by-count":2,"title":["Is Capillary Electrophoresis a New Tool to Monitor Acute Lithium Poisoning in Human?\u2020"],"prefix":"10.1093","volume":"43","author":[{"given":"Tsandni","family":"Jamal","sequence":"first","affiliation":[{"name":"Service de biochimie g\u00e9n\u00e9rale, H\u00f4pital universitaire Necker-Enfants Malades, AP-HP, rue de S\u00e8vres, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Hennequin","sequence":"additional","affiliation":[{"name":"Service de biochimie g\u00e9n\u00e9rale, H\u00f4pital universitaire Necker-Enfants Malades, AP-HP, rue de S\u00e8vres, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabah","family":"Gahoual","sequence":"additional","affiliation":[{"name":"Laboratoire de chimie analytique, Facult\u00e9 de Pharmacie, Universit\u00e9 Paris Descartes, 4 avenue de l\u2019Observatoire, Paris, France"},{"name":"Unit\u00e9 de Technologies Biologiques et Chimiques pour la Sant\u00e9 (UTCBS), Paris 5-CNRS UMR8258 Inserm U1022, Facult\u00e9 de Pharmacie, Universit\u00e9 Paris Descartes, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Leyris","sequence":"additional","affiliation":[{"name":"Laboratoire de chimie analytique, Facult\u00e9 de Pharmacie, Universit\u00e9 Paris Descartes, 4 avenue de l\u2019Observatoire, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Beaudeux","sequence":"additional","affiliation":[{"name":"Service de biochimie g\u00e9n\u00e9rale, H\u00f4pital universitaire Necker-Enfants Malades, AP-HP, rue de S\u00e8vres, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric J","family":"Baud","sequence":"additional","affiliation":[{"name":"Assistance Publique \u2013 H\u00f4pitaux de Paris, D\u00e9partement d\u2019Anesth\u00e9sie et de R\u00e9animation, Adult Intensive Care Unit, Centre hospitalo-universitaire Necker \u2013 Enfants Malades, 149 rue de S\u00e8vres, Paris, Universit\u00e9 Paris Descartes, France"},{"name":"EA7323 Evaluation of Therapeutics and Pharmacology in Perinatality and Pediatrics - H\u00f4pitaux Universitaires Cochin \u2013 Broca \u2013 H\u00f4tel Dieu, Site Tarnier, Universit\u00e9 Paris Descartes, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Houz\u00e9","sequence":"additional","affiliation":[{"name":"Service de biochimie g\u00e9n\u00e9rale, H\u00f4pital universitaire Necker-Enfants Malades, AP-HP, rue de S\u00e8vres, Paris, France"},{"name":"Laboratoire de chimie analytique, Facult\u00e9 de Pharmacie, Universit\u00e9 Paris Descartes, 4 avenue de l\u2019Observatoire, Paris, France"},{"name":"Unit\u00e9 de Technologies Biologiques et Chimiques pour la Sant\u00e9 (UTCBS), Paris 5-CNRS UMR8258 Inserm U1022, Facult\u00e9 de Pharmacie, Universit\u00e9 Paris Descartes, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,3,16]]},"reference":[{"key":"2019091012032761600_bkz013C1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19072143","article-title":"A history of the pharmacological treatment of bipolar disorder","volume":"19","author":"L\u00f3pez-Mu\u00f1oz","year":"2018","journal-title":"International Journal of Molecular Sciences"},{"key":"2019091012032761600_bkz013C2","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1134\/S0006297914080021","article-title":"Lithium salts\u2014simple but 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