{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:22:43Z","timestamp":1777656163612,"version":"3.51.4"},"reference-count":26,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1093\/jat\/bkz040","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T11:24:32Z","timestamp":1556105072000},"source":"Crossref","is-referenced-by-count":3,"title":["Comparison of the Detection Windows of Heroin Metabolites in Human Urine Using Online SPE and LC\u2013MS\/MS: Importance of Morphine-3-Glucuronide"],"prefix":"10.1093","author":[{"given":"Luying","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of New Drug and Pharmaceutical Process, China State Institute of Pharmaceutical Industry, Shanghai, China"},{"name":"Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Institute of Forensic Science, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunfang","family":"Ni","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Institute of Forensic Science, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Shen","sequence":"additional","affiliation":[{"name":"Shanghai Police College, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhai","family":"Sheng","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Institute of Forensic Science, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Liang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Institute of Forensic Science, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Institute of Forensic Science, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yurong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Institute of Forensic Science, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,5,16]]},"reference":[{"key":"2019051611314122900_bkz040C1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/jat\/18.1.22","article-title":"Disposition of heroin and its metabolites in heroin-related deaths","volume":"18","author":"Bruce","year":"1994","journal-title":"Journal of Analytical Toxicology"},{"key":"2019051611314122900_bkz040C2","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1046\/j.1440-1681.1999.03090.x","article-title":"Human erythrocyte but not brain acetylcholinesterase hydrolyses heroin to morphine","volume":"26","author":"Asher","year":"1999","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"key":"2019051611314122900_bkz040C3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2174\/157488406775268219","article-title":"Pharmacokinetics and pharmacokinetic variability of heroin and its metabolites: review of the literature","volume":"1","author":"Rook","year":"2006","journal-title":"Current Clinical Pharmacology"},{"key":"2019051611314122900_bkz040C4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0304-3959(97)00142-5","article-title":"Systematic review of factors affecting the ratios of morphine and its major metabolites","volume":"74","author":"Faura","year":"1998","journal-title":"Pain"},{"key":"2019051611314122900_bkz040C5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jat\/15.1.1","article-title":"Forensic drug testing for opiates: I. Detection of 6-acetylmorphine in urine as an indicator of recent heroin exposure; drug and assay considerations and detection times","volume":"15","author":"Cone","year":"1991","journal-title":"Journal of Analytical Toxicology"},{"key":"2019051611314122900_bkz040C6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/jat\/21.5.346","article-title":"Morphine, morphine-3-glucuronide, morphine-6-glucuronide, and 6-monoacetylmorphine determined by means of atmospheric pressure chemical ionization-mass spectrometry-liquid chromatography in body fluids of heroin victims","volume":"21","author":"Bogusz","year":"1997","journal-title":"Journal of Analytical Toxicology"},{"key":"2019051611314122900_bkz040C7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/jat\/21.4.268","article-title":"Simultaneous determination of heroin, 6-monoacetylmorphine, morphine, and its glucuronides by liquid chromatography-atmospheric pressure ionspray-mass spectrometry","volume":"21","author":"Zuccaro","year":"1997","journal-title":"Journal of Analytical Toxicology"},{"key":"2019051611314122900_bkz040C8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0378-4347(00)00469-2","article-title":"Column-switching high-performance liquid chromatography-electrospray ionization mass spectrometry for identification of heroin metabolites in human urine","volume":"751","author":"Katagi","year":"2001","journal-title":"Journal of Chromatography B"},{"key":"2019051611314122900_bkz040C9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jat\/31.1.1","article-title":"Simultaneous determination of codeine, morphine, hydrocodone, hydromorphone, oxycodone, and 6-acetylmorphine in urine, serum, plasma, whole blood, and meconium by LC-MS-MS","volume":"31","author":"Coles","year":"2007","journal-title":"Journal of Analytical Toxicology"},{"key":"2019051611314122900_bkz040C10","doi-asserted-by":"crossref","first-page":"6857","DOI":"10.1016\/j.chroma.2010.08.043","article-title":"A hybrid liquid chromatography-mass spectrometry strategy in a forensic laboratory for opioid, cocaine and amphetamine classes in human urine using a hybrid linear ion trap-triple quadrupole mass spectrometer","volume":"1217","author":"Dowling","year":"2010","journal-title":"Journal of Chromatography. A"},{"key":"2019051611314122900_bkz040C11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jchromb.2013.02.020","article-title":"Simultaneous determination of opiates, methadone, buprenorphine and metabolites in human urine by superficially porous liquid chromatography tandem mass spectrometry","volume":"925","author":"Lin","year":"2013","journal-title":"Journal of Chromatography B"},{"key":"2019051611314122900_bkz040C12","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/dta.1486","article-title":"Direct and efficient liquid chromatographic-tandem mass spectrometric method for opiates in urine drug testing\u2014importance of 6-acetylmorphine and reduction of analytes","volume":"6","author":"Andersson","year":"2014","journal-title":"Drug Testing and Analysis"},{"key":"2019051611314122900_bkz040C13","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/jat\/bkx057","article-title":"Simultaneous quantitation of methamphetamine, ketamine, opiates and their metabolites in urine by SPE and LC-MS-MS","volume":"41","author":"Yang","year":"2017","journal-title":"Journal of Analytical Toxicology"},{"key":"2019051611314122900_bkz040C14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/jat\/bky002","article-title":"Metabolites of heroin in several different post-mortem matrices","volume":"42","author":"Thaulow","year":"2018","journal-title":"Journal of Analytical Toxicology"},{"key":"2019051611314122900_bkz040C15","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.1021\/ac100607v","article-title":"Automated online solid phase extraction ultra high performance liquid chromatography method coupled with tandem mass spectrometry for determination of forty-two therapeutic drugs and drugs of abuse in human urine","volume":"82","author":"Chiuminatto","year":"2010","journal-title":"Analytical Chemistry"},{"key":"2019051611314122900_bkz040C16","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/jat\/bku024","article-title":"Validation of an automated solid-phase extraction method for the analysis of 23 opioids, cocaine, and metabolites in urine with ultra-performance liquid chromatography-tandem mass spectrometry","volume":"38","author":"Ram\u00edrez Fern\u00e1ndez Mdel","year":"2014","journal-title":"Journal of Analytical Toxicology"},{"key":"2019051611314122900_bkz040C17","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/jat\/9.3.134","article-title":"Detection of O6-monoacetylmorphine in urine samples by GC\/MS as evidence for heroin use","volume":"9","author":"Fehn","year":"1985","journal-title":"Journal of Analytical Toxicology"},{"key":"2019051611314122900_bkz040C18","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/jat\/23.4.262","article-title":"Comparison of four derivatizing reagents for 6-acetylmorphine GC-MS analysis","volume":"23","author":"Kushnir","year":"1999","journal-title":"Journal of Analytical Toxicology"},{"key":"2019051611314122900_bkz040C19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.chroma.2005.04.056","article-title":"Development and application of a new on-line SPE system combined with LC\u2013MS\/MS detection for high throughput direct analysis of pharmaceutical compounds in plasma","volume":"1080","author":"Alnouti","year":"2005","journal-title":"Journal of Chromatography. A"},{"key":"2019051611314122900_bkz040C20","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.jchromb.2011.05.028","article-title":"Simultaneous analysis of chlorpyrifos and cypermethrin in cord blood plasma by online solid-phase extraction coupled with liquid chromatography-heated electrospray ionization tandem mass spectrometry","volume":"879","author":"Liao","year":"2011","journal-title":"Journal of Chromatography B"},{"key":"2019051611314122900_bkz040C21","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jchromb.2012.07.005","article-title":"High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS\/MS","volume":"903","author":"Ghassabian","year":"2012","journal-title":"Journal of Chromatography B"},{"key":"2019051611314122900_bkz040C22","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.jpba.2012.06.014","article-title":"Determination of amlodipine in human plasma using automated online solid-phase extraction HPLC-tandem mass spectrometry: Application to a bioequivalence study of Chinese volunteers","volume":"70","author":"Shentu","year":"2012","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"2019051611314122900_bkz040C23","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1002\/jssc.201600107","article-title":"Sensitive, automatic method for the determination of diazepam and its five metabolites in human oral fluid by online solid-phase extraction and liquid chromatography with tandem mass spectrometry","volume":"39","author":"Jiang","year":"2016","journal-title":"Journal of Separation Science"},{"key":"2019051611314122900_bkz040C24","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/1556-4029.12337","article-title":"Stability of morphine, codeine, and 6-acetylmorphine in blood at different sampling and storage conditions","volume":"59","author":"Papoutsis","year":"2014","journal-title":"Journal of Forensic Sciences"},{"key":"2019051611314122900_bkz040C25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.chroma.2015.03.064","article-title":"Determination of co-administrated opioids and benzodiazepines in urine using column-switching solid-phase extraction and liquid chromatography-tandem mass spectrometry","volume":"1395","author":"Xiong","year":"2015","journal-title":"Journal of Chromatography. A"},{"key":"2019051611314122900_bkz040C26","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/dta.2244","article-title":"Confirmation of recent heroin abuse: accepting the challenge","volume":"10","author":"Maas","year":"2018","journal-title":"Drug Testing and Analysis"}],"container-title":["Journal of Analytical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jat\/advance-article-pdf\/doi\/10.1093\/jat\/bkz040\/28654980\/bkz040.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"}],"deposited":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T15:36:28Z","timestamp":1558020988000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jat\/advance-article\/doi\/10.1093\/jat\/bkz040\/5490236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,16]]},"references-count":26,"URL":"https:\/\/doi.org\/10.1093\/jat\/bkz040","relation":{},"ISSN":["0146-4760","1945-2403"],"issn-type":[{"value":"0146-4760","type":"print"},{"value":"1945-2403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,16]]},"article-number":"bkz040"}}