{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T21:55:53Z","timestamp":1722290153335},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"inventors of the patents","award":["JP5371779","US8715655","EP2236605"],"award-info":[{"award-number":["JP5371779","US8715655","EP2236605"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study introduces a novel monoclonal anti-\u03b19 integrin antibody (MA9-413) with human variable regions, isolated by phage display technology. MA9-413 specifically binds to both human and mouse \u03b19 integrin by recognizing a conserved loop region designated as L1 (amino acids 104\u2013122 of human \u03b19 integrin). MA9-413 inhibits human and mouse \u03b19 integrin-dependent cell adhesion to ligands and suppresses synovial inflammation and osteoclast activation in a mouse model of arthritis. This is the first monoclonal anti-\u03b19 integrin antibody that can react with and functionally inhibit both human and mouse \u03b19 integrin. MA9-413 allows data acquisition both in animal and human pharmacological studies without resorting to surrogate antibodies. Since MA9-413 showed certain therapeutic effects in the mouse arthritis model, it can be considered as a useful therapy against rheumatoid arthritis and other \u03b19 integrin-associated diseases.<\/jats:p>","DOI":"10.1093\/jb\/mvaa040","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T07:08:56Z","timestamp":1585897736000},"page":"231-241","source":"Crossref","is-referenced-by-count":4,"title":["A novel monoclonal antibody cross-reactive with both human and mouse \u03b19 integrin useful for therapy against rheumatoid arthritis"],"prefix":"10.1093","volume":"168","author":[{"given":"Masaharu","family":"Torikai","sequence":"first","affiliation":[{"name":"Research & Development Division, KM Biologics Co., Ltd, 1314-1 Kyokushi-Kawabe, Kikuchi, Kumamoto 869-1298, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Research & Development Division, KM Biologics Co., Ltd, 1314-1 Kyokushi-Kawabe, Kikuchi, Kumamoto 869-1298, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuchika","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Research & Development Division, KM Biologics Co., Ltd, 1314-1 Kyokushi-Kawabe, Kikuchi, Kumamoto 869-1298, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotada","family":"Fujita","sequence":"additional","affiliation":[{"name":"Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunari","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Sakai","sequence":"additional","affiliation":[{"name":"EVEC Inc., 6 Odori Nishi, Chuo-ku, Sapporo 060-0042, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Soejima","sequence":"additional","affiliation":[{"name":"Research & Development Division, KM Biologics Co., Ltd, 1314-1 Kyokushi-Kawabe, Kikuchi, Kumamoto 869-1298, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Nakashima","sequence":"additional","affiliation":[{"name":"The Chemo-Sero-Therapeutic Research Institute (Kaketsuken), 4-7 Hanabatacho, Chuo-ku, Kumamoto 860-0806, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,5,13]]},"reference":[{"key":"2020101308543604900_mvaa040-B1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.biotechadv.2016.07.004","article-title":"Therapeutic monoclonal antibodies and derivatives: historical perspectives and future directions","volume":"34","author":"Rodgers","year":"2016","journal-title":"Biotechnol. 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