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The catalytic activity of 12S-lipoxygenase that was hardly observed in liver cytosol of normal chow-fed mice was clearly detectable in that of NASH model mice prepared by feeding a methionine and choline-deficient (MCD) diet. The product profile, substrate specificity and immunogenicity indicated that the enzyme was the platelet-type isoform. The expression levels of mRNA and protein of platelet-type 12S-lipoxygenase in the liver of MCD diet-fed mice were significantly increased compared with those of normal chow-fed mice. Immunohistochemical analysis showed that platelet-type 12S-lipoxygenase colocalized with \u03b1-smooth muscle actin as well as vitamin A in the cells distributing along liver sinusoids. These results indicate that the expression level of platelet-type 12S-lipoxygenase in hepatic stellate cells was increased during the cell activation in MCD diet-fed mice, suggesting a possible role of the enzyme in pathophysiology of liver fibrosis.<\/jats:p>","DOI":"10.1093\/jb\/mvaa062","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T11:08:42Z","timestamp":1590664122000},"page":"455-463","source":"Crossref","is-referenced-by-count":6,"title":["Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice"],"prefix":"10.1093","volume":"168","author":[{"given":"Yoshiko","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719-1197, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719-1197, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Kanzaki","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719-1197, Japan"},{"name":"Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki, Okayama 701-0193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Otsuki","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719-1197, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719-1197, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hibiki","family":"Kanji","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719-1197, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoma","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719-1197, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Tsukayama","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719-1197, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Hojo","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719-1197, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiko","family":"Suzuki-Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719-1197, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayo","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719-1197, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719-1197, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"2020111113123380000_mvaa062-B1","doi-asserted-by":"crossref","first-page":"23679","DOI":"10.1074\/jbc.274.34.23679","article-title":"Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate","volume":"274","author":"Brash","year":"1999","journal-title":"J. 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