{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T17:02:11Z","timestamp":1784394131857,"version":"3.55.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Science and Technology Plan of Jiangxi Health and Family Planning Commission","award":["20175414"],"award-info":[{"award-number":["20175414"]}]},{"name":"Fund Project of Science and Technology Department of Jiangxi Province","award":["20181bbg78041"],"award-info":[{"award-number":["20181bbg78041"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Long non-coding RNA is an endogenous non-coding RNA that has currently been proved to be an important player in cancer cell biology. In the present study, we investigated the biological role of PHACTR2-AS1 in tongue squamous cell carcinoma (TSCC). PHACTR2-AS1 was preferentially localized in the cytoplasm, and was notably upregulated in TSCC tissues. High PHACTR2-AS1 was correlated with tumour differentiation, metastatic clinical features, relapse and shortened survival time. Depletion of PHACTR2-AS1 did not affect TSCC cell viability and colony formation ability, whereas substantially inhibited cell migration and invasion in vitro and lung metastasis in vivo. Mechanistically, PHACTR2-AS1 could sponge miR-137 to increase Snail expression, resulting in triggering epithelial\u2013mesenchymal transition process, thereby promoting TSCC cell metastasis. Taken together, our data for the first time elucidate the metastasis-promoting role of PHACTR2-AS1 in TSCC, hinting a new therapeutic target for metastatic TSCC patients.<\/jats:p>","DOI":"10.1093\/jb\/mvaa082","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T11:09:06Z","timestamp":1594984146000},"page":"651-657","source":"Crossref","is-referenced-by-count":15,"title":["Long non-coding RNA PHACTR2-AS1 promotes tongue squamous cell carcinoma metastasis by regulating Snail"],"prefix":"10.1093","volume":"168","author":[{"given":"Fenqian","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, Jiangxi Cancer Hospital, 519 East Beijing Road, Nanchang 330029, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery, Jiangxi Cancer Hospital, 519 East Beijing Road, Nanchang 330029, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Jiangxi Cancer Hospital, 519 East Beijing Road, Nanchang 330029, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanggeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jiangxi Cancer Hospital, 519 East Beijing Road, Nanchang 330029, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The First Affiliated Hospital of Suzhou University, No.188 Shizi Street, Suzhou 215006, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingkang","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Jiangxi Cancer Hospital, 519 East Beijing Road, Nanchang 330029, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The First Affiliated Hospital of Suzhou University, No.188 Shizi Street, Suzhou 215006, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"key":"2020122606293871500_mvaa082-B1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/0194599816674672","article-title":"Head and neck cancer: underfunded and understudied?","volume":"156","author":"Svider","year":"2017","journal-title":"Otolaryngol. 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