{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:53:21Z","timestamp":1778882001175,"version":"3.51.4"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Medical Engineering Cross Research Fund of Shandong University","award":["20180081"],"award-info":[{"award-number":["20180081"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Circular RNAs (circRNAs) are important regulators in various cancers. Previous studies have found that hsa_circ_0102231 is an oncogene in lung adenocarcinoma. Here, we investigated its mechanism in the development of non-small cell lung cancer (NSCLC). We detected the levels of hsa_circ_0102231 in five NSCLC cell lines and one normal bronchial epithelium cell line. The interaction between hsa_circ_0102231 and miR-145 was predicted and confirmed by pull-down and luciferase assays. The nuclear mass separation assay and fluorescence in situ hybridization were used to detect the distribution of hsa_circ_0102231. Cell Counting Kit-8 and Transwell assays were used to assess the cell proliferative and invasive ability. Western blot and RT-qPCR, respectively, detected the protein and mRNA levels of RBBP4. The RBBP4 promoter activity was detected with a luciferase assay. We found that hsa_circ_0102231 level was higher in NSCLC cells. hsa_circ_0102231 is mainly localized to the cytoplasm. hsa_circ_0102231 promotes NSCLC cell proliferation and invasion by sponge for miR-145. miR-145 significantly decreases the RBBP4 promoter activity, and its mRNA and protein levels. RBBP4 is an oncogene to promote proliferation and invasion ability. Our findings suggest that hsa_circ_0102231 promotes proliferation and invasion by mediating the miR-145\/RBBP4 axis in NSCLC, indicating that it might be a potential target for NSCLC treatment.<\/jats:p>","DOI":"10.1093\/jb\/mvaa093","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T11:23:57Z","timestamp":1596540237000},"page":"65-73","source":"Crossref","is-referenced-by-count":18,"title":["Circular RNA hsa_circ_0102231 sponges miR-145 to promote non-small cell lung cancer cell proliferation by up-regulating the expression of RBBP4"],"prefix":"10.1093","volume":"169","author":[{"given":"Xueru","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Heze Municipal Hospital, 2888 Caozhou Road, Heze, Shandong, 274000, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengzhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Heze Municipal Hospital, 2888 Caozhou Road, Heze, Shandong, 274000, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Heze Municipal Hospital, 2888 Caozhou Road, Heze, Shandong, 274000, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmei","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Heze Municipal Hospital, 2888 Caozhou Road, Heze, Shandong, 274000, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ailan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Heze Municipal Hospital, 2888 Caozhou Road, Heze, Shandong, 274000, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Heze Municipal Hospital, 2888 Caozhou Road, Heze, Shandong, 274000, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Heze Municipal Hospital, 2888 Caozhou Road, Heze, Shandong, 274000, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"2021020714255299700_mvaa093-B1","first-page":"7","article-title":"Cancer statistics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA: A Cancer J. 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