{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:15Z","timestamp":1792785975283,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Major Science and Technology Project of Changzhou Health Commission","award":["ZD201908"],"award-info":[{"award-number":["ZD201908"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The dysregulation of circular RNAs (circRNAs) has been identified in various human diseases. Here, we probed into the potential mechanism of circRNA_0092516 in osteoarthritis (OA). The expression of circRNA_0092516 was tested by quantitative real-time PCR. MTT, flow cytometry and western blot were applied to confirm the functions of circRNA_0092516 in vitro. Besides, RNA pull-down and dual-luciferase reporter gene experiments were applied to probe into the mechanism. circRNA_0092516 was raised in the tissues of OA patients and chondrocytes stimulated by IL-1\u03b2. The potential mechanism analysis expounded that circRNA_0092516 bound to miR-337-3p, and the interference with circRNA_0092516 boosted chondrocyte proliferation and restrained cell apoptosis through the miR-337-3p\/phosphatase and tensin homolog (PTEN) axis, thereby improving OA. In-vivo experiments expounded that circRNA_0092516 regulated cartilage production through miR-337-3p. Overall, our data expounded that the interference with circRNA_0092516 boosted chondrocyte proliferation and restrained cell apoptosis through the miR-337-3p\/PTEN axis, eventually slowed down the progress of OA.<\/jats:p>","DOI":"10.1093\/jb\/mvaa119","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T07:09:31Z","timestamp":1603350571000},"page":"467-475","source":"Crossref","is-referenced-by-count":54,"title":["CircRNA_0092516 regulates chondrocyte proliferation and apoptosis in osteoarthritis through the miR-337-3p\/PTEN axis"],"prefix":"10.1093","volume":"169","author":[{"given":"Zhihui","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Orthopedics, The Third Affiliated Hospital of Suchow University, No. 185 Juqian Road, Changzhou 213000, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Third Affiliated Hospital of Suchow University, No. 185 Juqian Road, Changzhou 213000, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhuai","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Third Affiliated Hospital of Suchow University, No. 185 Juqian Road, Changzhou 213000, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Third Affiliated Hospital of Suchow University, No. 185 Juqian Road, Changzhou 213000, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Third Affiliated Hospital of Suchow University, No. 185 Juqian Road, Changzhou 213000, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"2021042917153239100_mvaa119-B1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1136\/annrheumdis-2013-204763","article-title":"The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study","volume":"73","author":"Cross","year":"2014","journal-title":"Ann. 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