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GcvB, conserved in gram-negative enteric bacteria, is known to negatively control the expression of many genes for amino acid incorporation systems, especially the periplasmic ABC-transporter proteins. Deletions of several amino acid transporter genes in \u0394gcvB cells decreased the antibiotic sensitivity to the wild-type level, suggesting that those genes are involved in uptake of aminoglycosides into the cell. Since GcvB is constitutively synthesized in growing cells, repressing synthesis of amino acid transporters, it contributes to the intrinsic resistance to several aminoglycoside antibiotics.<\/jats:p>","DOI":"10.1093\/jb\/mvaa122","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T12:10:08Z","timestamp":1603887008000},"page":"485-489","source":"Crossref","is-referenced-by-count":8,"title":["Involvement of GcvB small RNA in intrinsic resistance to multiple aminoglycoside antibiotics in <i>Escherichia coli<\/i>"],"prefix":"10.1093","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5894-802X","authenticated-orcid":false,"given":"Akira","family":"Muto","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Bioscience, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Bioscience, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kurita","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Bioscience, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Ushida","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Bioscience, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyota","family":"Himeno","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Bioscience, Hirosaki University, Bunkyo-cho 3, Hirosaki, Aomori 036-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"2021042917153181300_mvaa122-B1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0960-9822(01)00270-6","article-title":"Novel small RNA-encoding genes in the intergenic regions of Escherichia coli","volume":"11","author":"Argaman","year":"2001","journal-title":"Curr. 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