{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:19:36Z","timestamp":1783635576006,"version":"3.55.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":550,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19ae0101026"],"award-info":[{"award-number":["JP19ae0101026"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research","award":["18K14655"],"award-info":[{"award-number":["18K14655"]}]},{"DOI":"10.13039\/501100012359","name":"Promotion and Mutual Aid Corporation for Private Schools of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mesothelioma is a highly aggressive tumour associated with asbestos exposure and is histologically classified into three types: epithelioid-type, sarcomatoid-type and biphasic-type. The prognosis of mesothelioma patients is poor and there is no effective molecular-targeting therapy as yet. ERC\/mesothelin is a glycoprotein that is highly expressed on several types of cancers including epithelioid mesothelioma, but also expressed on normal mesothelial cells. This is a predicted reason why there is no clinically approved therapeutic antibody targeting ERC\/mesothelin. In the present study, we focussed on the differential glycosylation between ERC\/mesothelin present on epithelioid mesothelioma and that on normal mesothelial cells and aimed to reveal a distinct feature of epithelioid mesothelioma cells. Lectin microarray analysis of ERC\/mesothelin using cells and patient specimens showed significantly stronger binding of PHA-E4 lectin, which recognizes complex-type N-glycans having a so-called bisecting-GlcNAc structure, to ERC\/mesothelin from epithelioid mesothelioma cells than that from normal mesothelial cells. Further, liquid chromatography\/mass spectrometry analysis on ERC\/mesothelin from epithelioid mesothelioma cells confirmed the presence of a bisecting-GlcNAc attached to Asn388 of ERC\/mesothelin. These results suggest that this glycoproteome could serve as a potential target for the generation of a highly selective and safe therapeutic antibody for epithelioid mesothelioma.<\/jats:p>","DOI":"10.1093\/jb\/mvab044","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T19:11:45Z","timestamp":1617131505000},"page":"317-326","source":"Crossref","is-referenced-by-count":5,"title":["Bisecting-GlcNAc on Asn388 is characteristic to ERC\/mesothelin expressed on epithelioid mesothelioma cells"],"prefix":"10.1093","volume":"170","author":[{"given":"Haruhiko","family":"Fujihira","sequence":"first","affiliation":[{"name":"Division of Glycobiologics, Intractable Disease Research Center, Juntendo University Graduate School of Medicine , 2-1-1 Hongo Bunkyo-ku, Tokyo 113-8421, Japan"},{"name":"Glycometabolic Biochemistry Laboratory, Cluster for Pioneering Research, RIKEN , 2-1 Hirosawa, Wako, Saitama 351-0198, 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