{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T23:41:31Z","timestamp":1652917291533},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>In addition to diurnal rhythms in physiology and behavior, a variety of pathological conditions also exhibit marked day\u2013night changes in symptom intensity, exemplified by allergic rhinitis, arthritis, asthma, myocardial infarction, congestive heart failure, stroke and chronic pain disorders. Currently, novel therapeutic approaches are facilitated by the development of chemical compounds targeted to key proteins that cause diurnal exacerbation of pathological events. Neuropathic pain is a chronic condition that occurs by tumor-induced nerve compression, cancer cell infiltration into the nerve, diabetes and herpes virus infection. One troublesome hallmark symptom of neuropathic pain is hypersensitivity to normally innocuous stimuli known as \u2018mechanical allodynia\u2019 that is often refractory to common analgesic therapies. Millions of patients worldwide presently endure neuropathic pain. We summarize the recent insights gained into the mechanism of diurnal exacerbation of neuropathic pain hypersensitivity and introduce the strategy of circadian clock-based drug development.<\/jats:p>","DOI":"10.1093\/jb\/mvab143","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T12:51:12Z","timestamp":1640782272000},"page":"487-492","source":"Crossref","is-referenced-by-count":1,"title":["Basis for diurnal exacerbation of neuropathic pain hypersensitivity and its application for drug development"],"prefix":"10.1093","volume":"171","author":[{"given":"Satoru","family":"Koyanagi","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Kusunose","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai","family":"Yasukochi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehiro","family":"Ohdo","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"2022051823010711200_ref1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3109\/07420529908998732","article-title":"Circadian variation in allergen and nonspecific bronchial responsiveness in asthma","volume":"16","author":"Jarjour","year":"1999","journal-title":"Chronobiol. 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