{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:28:00Z","timestamp":1787783280411,"version":"build-2784847793"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study sought to investigate the association between microRNA-29a (miR-29a) and cardiomyocyte apoptosis in diabetic cardiomyopathy (DCM). DCM rat model was established by treating rats with streptozotocin (STZ), followed by injection of NC or miR-29a-3p mimics into the myocardium of rats. High glucose (HG)-treated H9c2 cells were transfected with NC and miR-29a-3p mimics. DCM rats presented elevated levels of blood glucose, HbA1c, blood pressure, urine output, decreased body weight and cardiac contractile function after modeling. MiR-29a was lowly expressed in STZ-treated rats and HG-treated H9c2 cells. Upregulation of miR-29a improved cardiac structure and function and attenuated, alleviated myocardial histological abnormalities and fibrosis and lowered cardiomyocyte apoptosis in DCM rats. Meanwhile, HG promoted H9c2 cell apoptosis, while miR-29a overexpression attenuated the function of HG. Compared with control group, the protein expression of Bax, cleaved-caspase3 and Bak1 in DCM and HG groups were significantly upregulated, and the expression of Bcl-2 and Mcl-1 was downregulated, while miR-29a overexpression exerted opposite effect. Bioinformatics prediction method and western blot revealed that miR-29a directly targeted Bak1 and downregulated Bak1 expression. Overall, miR-29a regulated STZ- and HG-induced cardiomyocyte apoptosis by targeting Bak1, providing a novel understanding of the pathogenesis of DCM.<\/jats:p>","DOI":"10.1093\/jb\/mvac025","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T12:13:08Z","timestamp":1646914388000},"page":"663-671","source":"Crossref","is-referenced-by-count":11,"title":["MiR-29a regulates cardiomyocyte apoptosis by targeting Bak1 in diabetic cardiomyopathy"],"prefix":"10.1093","volume":"171","author":[{"given":"Xiaoyan","family":"Wang","sequence":"first","affiliation":[{"name":"The Second Hospital of Hebei Medical University Department of Cardiology, , Shijiazhuang, Hebei 050004, China"},{"name":"The Third Hospital of Shijiazhuang Affiliated to Hebei Medical University Department of Cardiology, , Shijiazhuang, Hebei 050011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhitao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hebei Medical University Clinical College Department of Experimental Center, , Shijiazhuang, Hebei 050031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Hebei Medical University Department of Cardiology, , Shijiazhuang, Hebei 050004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"2022061514303248000_ref1","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1161\/CIRCRESAHA.118.314665","article-title":"Diabetic cardiomyopathy","volume":"124","author":"Wolfgang","year":"2019","journal-title":"Circ. 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