{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:25:37Z","timestamp":1775064337800,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In terrestrial vertebrates, spermatozoa generated in the testis are transported through the reproductive tract toward outside the body. In addition to as the pathway of sperm transport, the male reproductive tract also functions as the site of post-testicular sperm maturation and the epididymis, which constitutes the majority of male reproductive tract, and plays central roles in such a sperm maturation. Recent studies with gene-modified animals have been unveiling not only the molecular mechanisms of sperm maturation in the epididymis but also the regulatory system by which the epididymis acquires and executes sperm-maturing functions. In this review, the mechanisms of mammalian sperm maturation will be summarized, based on recent findings, including the lumicrine regulation of sperm maturation.<\/jats:p>","DOI":"10.1093\/jb\/mvac071","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T04:47:07Z","timestamp":1662612427000},"page":"341-346","source":"Crossref","is-referenced-by-count":10,"title":["The molecular mechanisms of mammalian sperm maturation regulated by NELL2-ROS1 lumicrine signaling"],"prefix":"10.1093","volume":"172","author":[{"given":"Daiji","family":"Kiyozumi","sequence":"first","affiliation":[{"name":"Osaka University Research Institute for Microbial Diseases, , Suita, 565-0871, Japan"},{"name":"Japan Science and Technology Agency PRESTO, , Chiyoda-ku, 102-0076 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"2022120612535062500_ref1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1080\/17843286.1988.11717912","article-title":"How should we evaluate infertility in men and in women","volume":"43","author":"Comhaire","year":"1988","journal-title":"Acta Clin. 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