{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T07:28:50Z","timestamp":1750318130472},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immune reactions in the brain, the most complex organ that directly or indirectly regulates almost every part of the body and its actions, need to be tightly regulated. Recent findings in the field of neuroimmunology have enhanced our understanding of immune cells not only inside the brain but also in adjacent tissues. Multiple types of immune cells exist and are active in neighboring border tissues, even in the steady state. In addition, advances in technology have allowed researchers to characterize a broad range of cell types, including stromal cells that support immune reactions. This review presents a short overview of the roles of the immune system in the brain during health and disease, with focus on adaptive immunity and anatomical sites of action. We also discuss potential roles of stromal cells.<\/jats:p>","DOI":"10.1093\/jb\/mvad010","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T18:36:50Z","timestamp":1675276610000},"page":"145-151","source":"Crossref","is-referenced-by-count":2,"title":["Immunity in the brain and surrounding tissues"],"prefix":"10.1093","volume":"173","author":[{"given":"Mitsuhiro","family":"Kanamori","sequence":"first","affiliation":[{"name":"Kyushu University Division of Allergy and Immunology, Medical Institute of Bioregulation, , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minako","family":"Ito","sequence":"additional","affiliation":[{"name":"Kyushu University Division of Allergy and Immunology, Medical Institute of Bioregulation, , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a020412","article-title":"The blood-brain barrier","volume":"7","author":"Daneman","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2023030810061941700_","first-page":"58","article-title":"Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye","volume":"29","author":"Medawar","year":"1948","journal-title":"Br. J. Exp. Pathol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/path.1710990303","article-title":"The cellular reactions to heterologous, homologous and autologous skin implanted into brain","volume":"99","author":"Ridley","year":"1969","journal-title":"J. Pathol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0306-4522(94)00448-E","article-title":"Demyelination in the central nervous system following a delayed-type hypersensitivity response to bacillus Calmette-Guerin","volume":"64","author":"Matyszak","year":"1995","journal-title":"Neuroscience"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.it.2006.11.004","article-title":"What is immune privilege (not)?","volume":"28","author":"Galea","year":"2007","journal-title":"Trends Immunol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0165-5728(98)00145-3","article-title":"A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentation","volume":"90","author":"Perry","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.immuni.2017.06.007","article-title":"Myeloid cells in the central nervous system","volume":"46","author":"Herz","year":"2017","journal-title":"Immunity"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2020.12.040","article-title":"Functional characterization of the dural sinuses as a neuroimmune interface","volume":"184","author":"Rustenhoven","year":"2021","journal-title":"Cell"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/s41593-018-0227-9","article-title":"CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature","volume":"21","author":"Louveau","year":"2018","journal-title":"Nat. Neurosci."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nri.2016.144","article-title":"T cell responses in the central nervous system","volume":"17","author":"Korn","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The Glymphatic system: a Beginner's guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem. Res."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1084\/jem.20142290","article-title":"A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules","volume":"212","author":"Aspelund","year":"2015","journal-title":"J. Exp. Med."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.anorl.2011.03.002","article-title":"Anatomy and physiology of cerebrospinal fluid","volume":"128","author":"Sakka","year":"2011","journal-title":"Eur. Ann. Otorhinolaryngol. Head Neck Dis."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41586-019-1419-5","article-title":"Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid","volume":"572","author":"Ahn","year":"2019","journal-title":"Nature"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.29738","article-title":"Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI","volume":"6","author":"Absinta","year":"2017","journal-title":"elife"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.20220035","article-title":"Conserved meningeal lymphatic drainage circuits in mice and humans","volume":"219","author":"Jacob","year":"2022","journal-title":"J. Exp. Med."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3171\/jns.1986.64.3.0466","article-title":"Ultrastructural morphology of the olfactory pathway for cerebrospinal fluid drainage in the rabbit","volume":"64","author":"Erlich","year":"1986","journal-title":"J. Neurosurg."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.it.2016.08.001","article-title":"Neurological disease as a failure of brain-immune crosstalk: the multiple faces of Neuroinflammation","volume":"37","author":"Schwartz","year":"2016","journal-title":"Trends Immunol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri1130","article-title":"Three or more routes for leukocyte migration into the central nervous system","volume":"3","author":"Ransohoff","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41583-021-00525-w","article-title":"Emerging roles for CNS fibroblasts in health, injury and disease","volume":"23","author":"Dorrier","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1146\/annurev-physiol-022516-034406","article-title":"Microglia in physiology and disease","volume":"79","author":"Wolf","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.660523","article-title":"Microglia in health and disease: the strength to be diverse and reactive","volume":"15","author":"Uriarte, Huarte","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/nn.4610","article-title":"High-dimensional, single-cell characterization of the brain's immune compartment","volume":"20","author":"Korin","year":"2017","journal-title":"Nat. Neurosci."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/s41593-019-0393-4","article-title":"A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment","volume":"22","author":"Van Hove","year":"2019","journal-title":"Nat. Neurosci."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/ni.3423","article-title":"Origin, fate and dynamics of macrophages at central nervous system interfaces","volume":"17","author":"Goldmann","year":"2016","journal-title":"Nat. Immunol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1084\/jem.20102657","article-title":"Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain","volume":"208","author":"Anandasabapathy","year":"2011","journal-title":"J. Exp. Med."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/(SICI)1096-9861(19990322)405:4<553::AID-CNE8>3.0.CO;2-6","article-title":"Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations","volume":"405","author":"McMenamin","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/science.abf9277","article-title":"Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders","volume":"373","author":"Brioschi","year":"2021","journal-title":"Science"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1016\/j.neuron.2021.10.022","article-title":"GABAergic neuronal IL-4R mediates T cell effect on memory","volume":"109","author":"Herz","year":"2021","journal-title":"Neuron"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature18626","article-title":"Unexpected role of interferon-gamma in regulating neuronal connectivity and social behaviour","volume":"535","author":"Filiano","year":"2016","journal-title":"Nature"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1084\/jem.20091419","article-title":"Regulation of learning and memory by meningeal immunity: a key role for IL-4","volume":"207","author":"Derecki","year":"2010","journal-title":"J. Exp. Med."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/s41590-020-0776-4","article-title":"Meningeal gammadelta T cells regulate anxiety-like behavior via IL-17a signaling in neurons","volume":"21","author":"Alves de Lima","year":"2020","journal-title":"Nat. Immunol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/s41593-018-0213-2","article-title":"Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration","volume":"21","author":"Herisson","year":"2018","journal-title":"Nat. Neurosci."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41593-018-0301-3","article-title":"Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections","volume":"22","author":"Cai","year":"2019","journal-title":"Nat. Neurosci."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/s41593-021-00880-y","article-title":"Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges","volume":"24","author":"Schafflick","year":"2021","journal-title":"Nat. Neurosci."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/science.abf7844","article-title":"Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma","volume":"373","author":"Cugurra","year":"2021","journal-title":"Science"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/(SICI)1097-0029(19980401)41:1<43::AID-JEMT5>3.0.CO;2-V","article-title":"Origin, nature, and some functional considerations of intraventricular macrophages, with special reference to the epiplexus cells","volume":"41","author":"Ling","year":"1998","journal-title":"Microsc. Res. Tech."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.neuron.2020.08.024","article-title":"Tracking calcium dynamics and immune surveillance at the choroid plexus blood-cerebrospinal fluid Interface","volume":"108","author":"Shipley","year":"2020","journal-title":"Neuron"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1073\/pnas.1211270110","article-title":"CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging","volume":"110","author":"Baruch","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1016\/j.cell.2021.04.003","article-title":"A cellular and spatial map of the choroid plexus across brain ventricles and ages","volume":"184","author":"Dani","year":"2021","journal-title":"Cell"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22094405","article-title":"Neuroinflammation in post-ischemic neurodegeneration of the brain: friend, foe, or both?","volume":"22","author":"Pluta","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1177\/0271678X17694185","article-title":"Depletion of microglia exacerbates postischemic inflammation and brain injury","volume":"37","author":"Jin","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"11499","DOI":"10.1038\/ncomms11499","article-title":"Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke","volume":"7","author":"Szalay","year":"2016","journal-title":"Nat. Commun."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/ana.23529","article-title":"Macrophages prevent hemorrhagic infarct transformation in murine stroke models","volume":"71","author":"Gliem","year":"2012","journal-title":"Ann. Neurol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1182\/blood-2009-10-249078","article-title":"Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation","volume":"115","author":"Kleinschnitz","year":"2010","journal-title":"Blood"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1161\/CIRCULATIONAHA.105.593046","article-title":"Role of T lymphocytes and interferon-gamma in ischemic stroke","volume":"113","author":"Yilmaz","year":"2006","journal-title":"Circulation"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12974-017-0890-x","article-title":"B cells do not have a major pathophysiologic role in acute ischemic stroke in mice","volume":"14","author":"Schuhmann","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nm.1999","article-title":"Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury","volume":"15","author":"Shichita","year":"2009","journal-title":"Nat. Med."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nm.1927","article-title":"Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke","volume":"15","author":"Liesz","year":"2009","journal-title":"Nat. Med."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41586-018-0824-5","article-title":"Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery","volume":"565","author":"Ito","year":"2019","journal-title":"Nature"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1177\/0271678X18822921","article-title":"Impaired meningeal lymphatic vessel development worsens stroke outcome","volume":"40","author":"Yanev","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nm.4068","article-title":"Commensal microbiota affects ischemic stroke outcome by regulating intestinal gammadelta T cells","volume":"22","author":"Benakis","year":"2016","journal-title":"Nat. Med."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","article-title":"A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17","volume":"6","author":"Park","year":"2005","journal-title":"Nat. Immunol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jns.2013.03.002","article-title":"Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination","volume":"333","author":"Rostami","year":"2013","journal-title":"J. Neurol. Sci."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.4049\/jimmunol.175.5.3025","article-title":"Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system","volume":"175","author":"McGeachy","year":"2005","journal-title":"J. Immunol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.immuni.2015.11.010","article-title":"Integration of Th17- and Lymphotoxin-derived signals initiates meningeal-resident stromal cell remodeling to propagate Neuroinflammation","volume":"43","author":"Pikor","year":"2015","journal-title":"Immunity"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/s41593-022-01108-3","article-title":"Distinct roles of the meningeal layers in CNS autoimmunity","volume":"25","author":"Merlini","year":"2022","journal-title":"Nat. Neurosci."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41593-020-00770-9","article-title":"CNS fibroblasts form a fibrotic scar in response to immune cell infiltration","volume":"24","author":"Dorrier","year":"2021","journal-title":"Nat. Neurosci."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jneuroim.2008.04.035","article-title":"Involvement of the choroid plexus in multiple sclerosis autoimmune inflammation: a neuropathological study","volume":"199","author":"Vercellino","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/ni.1716","article-title":"C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE","volume":"10","author":"Reboldi","year":"2009","journal-title":"Nat. Immunol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clim.2017.04.014","article-title":"Effector and regulatory B cells in multiple sclerosis","volume":"184","author":"Staun-Ram","year":"2017","journal-title":"Clin. Immunol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.cell.2018.11.035","article-title":"Recirculating intestinal IgA-producing cells regulate Neuroinflammation via IL-10","volume":"176","author":"Rojas","year":"2019","journal-title":"Cell"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1056\/NEJMoa0706383","article-title":"B-cell depletion with rituximab in relapsing-remitting multiple sclerosis","volume":"358","author":"Hauser","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.it.2020.07.005","article-title":"Immunological features of non-neuronal brain cells: implications for Alzheimer's disease immunotherapy","volume":"41","author":"Castellani","year":"2020","journal-title":"Trends Immunol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.3389\/fnins.2019.01178","article-title":"Brain-immune interactions and Neuroinflammation after traumatic brain injury","volume":"13","author":"Dinet","year":"2019","journal-title":"Front. Neurosci."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.molmed.2018.04.003","article-title":"Advances in meningeal immunity","volume":"24","author":"Rua","year":"2018","journal-title":"Trends Mol. Med."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41586-018-0368-8","article-title":"Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease","volume":"560","author":"Da Mesquita","year":"2018","journal-title":"Nature"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1038\/s41467-020-18113-4","article-title":"Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis","volume":"11","author":"Bolte","year":"2020","journal-title":"Nat. Commun."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41590-018-0086-2","article-title":"Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury","volume":"19","author":"Russo","year":"2018","journal-title":"Nat. Immunol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/s41590-021-01012-1","article-title":"Antimicrobial immunity impedes CNS vascular repair following brain injury","volume":"22","author":"Mastorakos","year":"2021","journal-title":"Nat. Immunol."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41593-022-01029-1","article-title":"Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels","volume":"25","author":"Mazzitelli","year":"2022","journal-title":"Nat. Neurosci."},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/science.aax7171","article-title":"Cerebrospinal fluid influx drives acute ischemic tissue swelling","volume":"367","author":"Mestre","year":"2020","journal-title":"Science"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"ENEURO.0448","DOI":"10.1523\/ENEURO.0448-18.2019","article-title":"Tmem119-EGFP and Tmem119-CreERT2 transgenic mice for labeling and manipulating microglia","volume":"6","author":"Kaiser","year":"2019","journal-title":"eNeuro"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/dvg.20603","article-title":"A mouse line expressing Sall1-driven inducible Cre recombinase in the kidney mesenchyme","volume":"48","author":"Inoue","year":"2010","journal-title":"Genesis"},{"key":"2023030810061941700_","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41590-020-0707-4","article-title":"Novel Hexb-based tools for studying microglia in the CNS","volume":"21","author":"Masuda","year":"2020","journal-title":"Nat. Immunol."}],"container-title":["The Journal of Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jb\/advance-article-pdf\/doi\/10.1093\/jb\/mvad010\/49236370\/mvad010.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jb\/article-pdf\/173\/3\/145\/49447885\/mvad010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jb\/article-pdf\/173\/3\/145\/49447885\/mvad010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T22:10:04Z","timestamp":1701814204000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jb\/article\/173\/3\/145\/7017860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,1]]},"references-count":76,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2,1]]},"published-print":{"date-parts":[[2023,3,7]]}},"URL":"https:\/\/doi.org\/10.1093\/jb\/mvad010","relation":{},"ISSN":["0021-924X","1756-2651"],"issn-type":[{"value":"0021-924X","type":"print"},{"value":"1756-2651","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3]]},"published":{"date-parts":[[2023,2,1]]}}}