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Although metastasis is a major cause of cancer-related deaths, an effective treatment has not yet been established. Here, we explore the antitumor effects of GO-Y030, a curcumin analog, via various mechanisms using a mouse model. GO-Y030 treatment of B16-F10 melanoma cells inhibited TGF-\u03b2 expression and glycolysis. The invasion assay results showed almost complete invasion inhibition following GO-Y030 treatment. Mouse experiments demonstrated that GO-Y030 administration inhibited lung tumor metastasis without affecting vascular endothelial cells. Consistent with this result, GO-Y030 treatment led to the downregulation of MMP2 and VEGF\u03b1, inhibiting tumor invasion and metastasis. The silencing of eIF4B, a downstream molecule of S6, attenuated MMP2 expression. Our study demonstrates the novel efficacy of GO-Y030 in inhibiting tumor metastasis by regulating metastasis-associated gene expression via inhibiting dual access, glycolytic and TGF-\u03b2 pathways.<\/jats:p>","DOI":"10.1093\/jb\/mvad066","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T19:16:15Z","timestamp":1693595775000},"page":"511-518","source":"Crossref","is-referenced-by-count":6,"title":["Curcumin analog GO-Y030 inhibits tumor metastasis and glycolysis"],"prefix":"10.1093","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0820-3219","authenticated-orcid":false,"given":"Takashi","family":"MaruYama","sequence":"first","affiliation":[{"name":"Tohoku University Graduate School of Medicine Department of Organ Anatomy, , Seiryo 2-1, Aoba, Sendai, Miyagi, 980-8575, Japan"},{"name":"Akita University, Graduate School of Medicine Department of Immunology, , Hondo 1-1, Akita, Akita, 010-8543, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine Department of Organ Anatomy, , Seiryo 2-1, Aoba, Sendai, Miyagi, 980-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taishi","family":"Komori","sequence":"additional","affiliation":[{"name":"National Institutes of Health Molecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research(NIDCR), , 30 convent drive, Building 30, Bethesda, MD, 20892, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shion","family":"Osana","sequence":"additional","affiliation":[{"name":"University of Electro-Communications, Graduate School of Informatics and Engineering Department of Engineering Science, , Chofugaoka 1-5-1, Chofu, Tokyo, 182-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Shibata","sequence":"additional","affiliation":[{"name":"Akita University, Graduate School of Medicine Department of Clinical Oncology, , Hondo 1-1, Akita, Akita, 010-8543, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Owada","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine Department of Organ Anatomy, , Seiryo 2-1, Aoba, Sendai, Miyagi, 980-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine Department of Organ Anatomy, , Seiryo 2-1, Aoba, Sendai, Miyagi, 980-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"key":"2024040907353531000_ref1","doi-asserted-by":"crossref","first-page":"7428","DOI":"10.1158\/0008-5472.CAN-07-6734","article-title":"Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1","volume":"68","author":"Chen","year":"2008","journal-title":"Cancer Res."},{"key":"2024040907353531000_ref2","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.1038\/onc.2016.106","article-title":"HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms","volume":"35","author":"Chen","year":"2016","journal-title":"Oncogene"},{"key":"2024040907353531000_ref3","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of curcumin: problems and promises","volume":"4","author":"Anand","year":"2007","journal-title":"Mol. 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