{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:25:50Z","timestamp":1785446750568,"version":"3.56.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Oriental Medicine Research Foundation and JST SRPING","award":["JPMJSP2130"],"award-info":[{"award-number":["JPMJSP2130"]}]},{"name":"JSPS, and Grants-in-Aid for Research","award":["2221102"],"award-info":[{"award-number":["2221102"]}]},{"name":"Japan Society for the Promotion of Science (JSPS), a Grant-in-Aid for Young Scientists","award":["18\u00a0K16081"],"award-info":[{"award-number":["18\u00a0K16081"]}]},{"name":"Grant-in-Aid for Scientific Research","award":["21H02650"],"award-info":[{"award-number":["21H02650"]}]},{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"crossref","award":["18\u00a0K06660 and 20\u00a0K07052"],"award-info":[{"award-number":["18\u00a0K06660 and 20\u00a0K07052"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cardiac glycosides (CGs) have been used for decades to treat heart failure and arrhythmic diseases. Recent non-clinical and epidemiological findings have suggested that CGs exhibit anti-tumor activities. Therefore, CGs may be repositioned as drugs for the treatment of cancer. A detailed understanding of the anti-cancer mechanisms of CGs is essential for their application to the treatment of targetable cancer types. To elucidate the factors associated with the anti-tumor effects of CGs, we performed transcriptome profiling on human multiple myeloma AMO1 cells treated with periplocin, one of the CGs. Periplocin significantly down-regulated the transcription of MYC (c-Myc), a well-established oncogene. Periplocin also suppressed c-Myc expression at the protein levels. This repression of c-Myc was also observed in several cell lines. To identify target proteins for the inhibition of c-Myc, we generated CG-resistant (C9) cells using a sustained treatment with digoxin. We confirmed that C9 cells acquired resistance to the inhibition of c-Myc expression and cell proliferation by CGs. Moreover, the sequencing of genomic DNA in C9 cells revealed the mutation of D128N in \u03b11-Na\/K-ATPase, indicating the target protein. These results suggest that CGs suppress c-Myc expression in cancer cells via \u03b11-Na\/K-ATPase, which provides further support for the anti-tumor activities of CGs.<\/jats:p>","DOI":"10.1093\/jb\/mvad085","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T20:22:21Z","timestamp":1699647741000},"page":"253-263","source":"Crossref","is-referenced-by-count":5,"title":["Involvement of cardiac glycosides targeting Na\/K-ATPase in their inhibitory effects on c-Myc expression <i>via<\/i> its transcription, translation and proteasomal degradation"],"prefix":"10.1093","volume":"175","author":[{"given":"Muneshige","family":"Tokugawa","sequence":"first","affiliation":[{"name":"Nagoya City University Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, , 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1667-1381","authenticated-orcid":false,"given":"Yasumichi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Nagoya City University Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, , 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Aoki","sequence":"additional","affiliation":[{"name":"Nagoya City University Department of Pathobiology, Graduate School of Pharmaceutical Sciences, , 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiharu","family":"Miyajima","sequence":"additional","affiliation":[{"name":"Nagoya City University Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, , 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan'ichiro","family":"Ishiuchi","sequence":"additional","affiliation":[{"name":"Nagoya City University Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, , 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kento","family":"Tsurumi","sequence":"additional","affiliation":[{"name":"Nagoya City University Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, , 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisane","family":"Kujirai","sequence":"additional","affiliation":[{"name":"Nagoya City University Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, , 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Morishita","sequence":"additional","affiliation":[{"name":"Nagoya City University Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, , 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan"},{"name":"Chordia Therapeutics Inc. , 26-1 Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-0012, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiyo","family":"Matsuno","sequence":"additional","affiliation":[{"name":"Plant research section, The Kochi Prefectural Makino Botanical Garden , 4200-6 Godaiyama, Kochi 781-8125, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Mizukami","sequence":"additional","affiliation":[{"name":"Plant research section, The Kochi Prefectural Makino Botanical Garden , 4200-6 Godaiyama, Kochi 781-8125, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ri","sequence":"additional","affiliation":[{"name":"Nagoya City University Department of Hematology and Oncology, Graduate School of Medical Sciences, , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Iida","sequence":"additional","affiliation":[{"name":"Nagoya City University Department of Hematology and Oncology, Graduate School of Medical Sciences, , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Makino","sequence":"additional","affiliation":[{"name":"Nagoya City University Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, , 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mineyoshi","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Nagoya City University Department of Pathobiology, Graduate School of Pharmaceutical Sciences, , 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Nagoya City University Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, , 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"2024050904321011000_ref1","first-page":"32","article-title":"Cardiotonic steroids on the road to anti-cancer therapy","volume":"1776","author":"Mijatovic","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"2024050904321011000_ref2","doi-asserted-by":"crossref","first-page":"6602","DOI":"10.1074\/jbc.M112.442137","article-title":"A structural view on the functional importance of the sugar moiety and steroid hydroxyls of cardiotonic steroids in binding to Na,K-ATPase","volume":"288","author":"Cornelius","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2024050904321011000_ref3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2407-1-11","article-title":"Digitoxin medication and cancer; case control and internal dose-response studies","volume":"1","author":"Haux","year":"2001","journal-title":"BMC Cancer"},{"key":"2024050904321011000_ref4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1158\/2159-8274.CD-10-0020","article-title":"A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment","volume":"1","author":"Platz","year":"2011","journal-title":"Cancer Discov."},{"key":"2024050904321011000_ref5","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.bcp.2003.10.013","article-title":"Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells","volume":"67","author":"Huang","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"2024050904321011000_ref6","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1158\/1535-7163.MCT-05-0367","article-title":"The cardenolide UNBS1450 is able to deactivate nuclear factor \u03baB-mediated cytoprotective effects in human non-small cell lung cancer cells","volume":"5","author":"Mijatovic","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"2024050904321011000_ref7","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/leu.2016.341","article-title":"Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia","volume":"31","author":"Cerella","year":"2017","journal-title":"Leukemia"},{"key":"2024050904321011000_ref8","doi-asserted-by":"crossref","first-page":"e23082","DOI":"10.4161\/onci.23082","article-title":"Trial watch: cardiac glycosides and cancer therapy","volume":"2","author":"Menger","year":"2013","journal-title":"Oncoimmunology"},{"key":"2024050904321011000_ref9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cell.2012.03.003","article-title":"MYC on the path to cancer","volume":"149","author":"Dang","year":"2012","journal-title":"Cell"},{"key":"2024050904321011000_ref10","doi-asserted-by":"crossref","first-page":"a014365","DOI":"10.1101\/cshperspect.a014365","article-title":"MYC degradation","volume":"4","author":"Farrell","year":"2014","journal-title":"Cold Spring Harb Perspect Med."},{"key":"2024050904321011000_ref11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/excr.1999.4686","article-title":"Function of the c-Myc oncogenic transcription factor","volume":"253","author":"Dang","year":"1999","journal-title":"Exp. Cell Res."},{"key":"2024050904321011000_ref12","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.15252\/embj.201796438","article-title":"MYC and tumor metabolism: chicken and egg","volume":"36","author":"Dejure","year":"2017","journal-title":"EMBO J."},{"key":"2024050904321011000_ref13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ccell.2016.02.007","article-title":"A SIRT2-selective inhibitor promotes c-Myc oncoprotein degradation and exhibits broad anticancer activity","volume":"29","author":"Jing","year":"2016","journal-title":"Cancer Cell"},{"key":"2024050904321011000_ref14","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.cell.2011.08.017","article-title":"BET bromodomain inhibition as a therapeutic strategy to target c-Myc","volume":"146","author":"Delmore","year":"2011","journal-title":"Cell"},{"key":"2024050904321011000_ref15","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ccell.2019.10.001","article-title":"Small-molecule MYC inhibitors suppress tumor growth and enhance immunotherapy","volume":"36","author":"Han","year":"2019","journal-title":"Cancer Cell"},{"key":"2024050904321011000_ref16","doi-asserted-by":"crossref","first-page":"9528","DOI":"10.1038\/s41598-021-89074-x","article-title":"Periplocin and cardiac glycosides suppress the unfolded protein response","volume":"11","author":"Tokugawa","year":"2021","journal-title":"Sci. Rep."},{"key":"2024050904321011000_ref17","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1248\/bpb.b18-00892","article-title":"Lysine-specific demethylase 1 (LSD1\/KDM1A) is a novel target gene of c-Myc","volume":"42","author":"Nagasaka","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"2024050904321011000_ref18","first-page":"btz854","article-title":"RaNA-Seq: Interactive RNA-Seq analysis from FASTQ files to functional analysis","author":"Prieto","year":"2019","journal-title":"Bioinformatics"},{"key":"2024050904321011000_ref19","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"2024050904321011000_ref20","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3390\/ph15081015","article-title":"HMG-CoA reductase inhibitor statins activate the transcriptional activity of p53 by regulating the expression of TAZ","volume":"15","author":"Miyajima","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"key":"2024050904321011000_ref21","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/1873-3468.14296","article-title":"The deubiquitinating enzyme USP17 regulates c-Myc levels and controls cell proliferation and glycolysis","volume":"596","author":"Nagasaka","year":"2022","journal-title":"FEBS Lett."},{"key":"2024050904321011000_ref22","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/sj.onc.1209826","article-title":"Smad3 is acetylated by p300\/CBP to regulate its transactivation activity","volume":"26","author":"Inoue","year":"2007","journal-title":"Oncogene"},{"key":"2024050904321011000_ref23","doi-asserted-by":"crossref","first-page":"16429","DOI":"10.1074\/jbc.RA119.009006","article-title":"The ubiquitin-specific protease USP17 prevents cellular senescence by stabilizing the methyltransferase SET8 and transcriptionally repressing p21","volume":"294","author":"Fukuura","year":"2019","journal-title":"J. Biol. Chem."},{"key":"2024050904321011000_ref24","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3390\/molecules23061394","article-title":"Anti-tumorigenic activity of chrysin from Oroxylum indicum via non-genotoxic p53 activation through the ATM-Chk2 pathway","volume":"23","author":"Nagasaka","year":"2018","journal-title":"Molecules"},{"key":"2024050904321011000_ref25","doi-asserted-by":"crossref","first-page":"e8292","DOI":"10.1371\/journal.pone.0008292","article-title":"Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis","volume":"4","author":"Perne","year":"2009","journal-title":"PLoS One"},{"key":"2024050904321011000_ref26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nmeth.1314","article-title":"SUnSET, a nonradioactive method to monitor protein synthesis","volume":"6","author":"Schmidt","year":"2009","journal-title":"Nat. Methods"},{"key":"2024050904321011000_ref27","doi-asserted-by":"crossref","first-page":"100839","DOI":"10.1016\/j.jbc.2021.100839","article-title":"Glucose treatment of human pancreatic \u03b2-cells enhances translation of mRNAs involved in energetics and insulin secretion","volume":"297","author":"Zakaria","year":"2021","journal-title":"J. Biol. Chem."},{"key":"2024050904321011000_ref28","doi-asserted-by":"crossref","first-page":"10336","DOI":"10.1021\/acsomega.9b00366","article-title":"Targeting translation activity at the ribosome interface with UV-active small molecules","volume":"4","author":"Kandala","year":"2019","journal-title":"ACS Omega"},{"key":"2024050904321011000_ref29","doi-asserted-by":"crossref","first-page":"9367","DOI":"10.1073\/pnas.1705133114","article-title":"A p53-dependent response limits the viability of mammalian haploid cells","volume":"114","author":"Olbrich","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2024050904321011000_ref30","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/sj.gt.3303015","article-title":"OuaSelect, a novel ouabain-resistant human marker gene that allows efficient cell selection within 48 h","volume":"14","author":"Treschow","year":"2007","journal-title":"Gene Ther."},{"key":"2024050904321011000_ref31","doi-asserted-by":"crossref","first-page":"21902","DOI":"10.1016\/S0021-9258(20)88270-2","article-title":"Site-directed mutagenesis of a conserved, extracellular aspartic acid residue affects the ouabain sensitivity of sheep Na,K-ATPase","volume":"264","author":"Price","year":"1989","journal-title":"J. Biol. Chem."},{"key":"2024050904321011000_ref32","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/nrd2682","article-title":"Novel therapeutic applications of cardiac glycosides","volume":"7","author":"Prassas","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"2024050904321011000_ref33","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/path.2172","article-title":"The alpha1 subunit of the sodium pump could represent a novel target to combat non-small cell lung cancers","volume":"212","author":"Mijatovic","year":"2007","journal-title":"J. Pathol."},{"key":"2024050904321011000_ref34","doi-asserted-by":"crossref","first-page":"38079","DOI":"10.1038\/srep38079","article-title":"The role of PIM1\/PIM2 kinases in tumors of the male reproductive system","volume":"6","author":"Jim\u00e9nez-Garc\u00eda","year":"2016","journal-title":"Sci. Rep."},{"key":"2024050904321011000_ref35","doi-asserted-by":"crossref","first-page":"e325","DOI":"10.1038\/bcj.2015.46","article-title":"Targeting the Pim kinases in multiple myeloma","volume":"5","author":"Keane","year":"2015","journal-title":"Blood Cancer J."},{"key":"2024050904321011000_ref36","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(93)90500-P","article-title":"WAF1, a potential mediator of p53 tumor suppression","volume":"75","author":"El-Deiry","year":"1993","journal-title":"Cell"},{"key":"2024050904321011000_ref37","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1126\/science.1090072","article-title":"p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa","volume":"302","author":"Villunger","year":"2003","journal-title":"Science"},{"key":"2024050904321011000_ref38","doi-asserted-by":"crossref","first-page":"59572","DOI":"10.18632\/oncotarget.10726","article-title":"Oleandrin induces DNA damage responses in cancer cells by suppressing the expression of Rad51","volume":"7","author":"Bao","year":"2016","journal-title":"Oncotarget"},{"key":"2024050904321011000_ref39","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1038\/bjc.2012.159","article-title":"Quiescence and \u03b3H2AX in neuroblastoma are regulated by ouabain\/Na,K-ATPase","volume":"106","author":"Hiyoshi","year":"2012","journal-title":"Br. J. Cancer"},{"key":"2024050904321011000_ref40","doi-asserted-by":"crossref","first-page":"16669","DOI":"10.1073\/pnas.1108190108","article-title":"Targeting MYC dependence in cancer by inhibiting BET bromodomains","volume":"108","author":"Mertz","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2024050904321011000_ref41","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.cell.2020.03.038","article-title":"Selective PP2A enhancement through biased heterotrimer stabilization","volume":"181","author":"Leonard","year":"2020","journal-title":"Cell"},{"key":"2024050904321011000_ref42","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s13046-019-1242-8","article-title":"Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation","volume":"38","author":"Da Costa","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"2024050904321011000_ref43","doi-asserted-by":"crossref","first-page":"24120","DOI":"10.1016\/S0021-9258(19)51056-0","article-title":"Identification of an amino acid substitution in human alpha 1 Na,K-ATPase which confers differentially reduced affinity for two related cardiac glycosides","volume":"269","author":"Askew","year":"1994","journal-title":"J. Biol. Chem."},{"key":"2024050904321011000_ref44","doi-asserted-by":"crossref","first-page":"C126","DOI":"10.1152\/ajpcell.00089.2015","article-title":"Cardiac glycosides induced toxicity in human cells expressing \u03b11-, \u03b12-, or \u03b13-isoforms of Na-K-ATPase","volume":"309","author":"Cherniavsky Lev","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2024050904321011000_ref45","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0926-6585(65)90011-7","article-title":"The role of Na+ and K+ in the ouabain-inhibition of the Na+ + K+-activated membrane adenosine triphosphatase","volume":"94","author":"Schatzmann","year":"1965","journal-title":"Biochim. Biophys. Acta"},{"key":"2024050904321011000_ref46","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1046\/j.1432-1033.2002.02910.x","article-title":"Na(+)\/K(+)-ATPase as a signal transducer","volume":"269","author":"Xie","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"2024050904321011000_ref47","doi-asserted-by":"crossref","first-page":"18694","DOI":"10.1074\/jbc.M111357200","article-title":"Src-mediated inter-receptor cross-talk between the Na+\/K+-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases","volume":"277","author":"Haas","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2024050904321011000_ref48","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1016\/j.bbadis.2018.09.014","article-title":"Crosstalk between Na+,K+-ATPase and a volume-regulated anion channel in membrane microdomains of human cancer cells","volume":"1864","author":"Fujii","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"2024050904321011000_ref49","doi-asserted-by":"crossref","first-page":"10585","DOI":"10.1074\/jbc.M609181200","article-title":"Identification of a pool of non-pumping Na\/K-ATPase","volume":"282","author":"Liang","year":"2007","journal-title":"J. Biol. Chem."}],"container-title":["The Journal of Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jb\/advance-article-pdf\/doi\/10.1093\/jb\/mvad085\/54025490\/mvad085.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jb\/article-pdf\/175\/3\/253\/57457821\/mvad085.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jb\/article-pdf\/175\/3\/253\/57457821\/mvad085.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T04:34:03Z","timestamp":1715229243000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jb\/article\/175\/3\/253\/7390644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,8]]},"references-count":49,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,11,8]]},"published-print":{"date-parts":[[2024,3,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jb\/mvad085","relation":{},"ISSN":["0021-924X","1756-2651"],"issn-type":[{"value":"0021-924X","type":"print"},{"value":"1756-2651","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2023,11,8]]}}}