{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:46:27Z","timestamp":1776703587897,"version":"3.51.2"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Research Grant from the Osaka Metropolitan University Strategic Research Initiative"},{"name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","award":["13760105 and 21K19661"],"award-info":[{"award-number":["13760105 and 21K19661"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lactoferrin is a multifunctional protein mainly involved in the immune defence mechanisms against various pathogens. It has been reported that intestinal inflammation was reduced by lactoferrin administration. However, the precise mechanism underlying lactoferrin\u2019s involvement in intestinal inflammation is not yet fully understood. In this study, we purified a mouse intestinal lactoferrin-binding protein with a molecular mass of ~400\u00a0kDa that was expressed in the small intestine and colon. Sequence analysis revealed that the intestinal lactoferrin-binding protein represented an ortholog of rat immunoglobulin G fragment crystallizable gamma-binding protein (IgGFc\u03b3BP). N-linked glycans of lactoferrin were not necessary for binding to IgGFc\u03b3BP. After reduction, IgGFc\u03b3BP was separated into fragments of 120, 70, 65, 60, and 55 kDa, none of which bound lactoferrin. The expression of IgGFc\u03b3BP was lost in a mouse model of dextran sodium sulphate-induced colitis and restored during the convalescence period of colitis, suggesting a role in mucosal protection and immune regulation. Furthermore, we discuss potential links between IgGFc\u03b3BP and mucin-associated microbiota, which may contribute to lactoferrin\u2019s immunomodulatory effects. These findings provide new insights into the interaction between lactoferrin, mucosal immunity, and gut microbiota.<\/jats:p>","DOI":"10.1093\/jb\/mvaf064","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:10:10Z","timestamp":1762002610000},"page":"99-106","source":"Crossref","is-referenced-by-count":1,"title":["Purification and characterization of an IgG Fc gamma binding protein from the mouse intestine that interacts with lactoferrin"],"prefix":"10.1093","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3194-7937","authenticated-orcid":false,"given":"DongHo","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Nutrition, Graduate School of Human Life and Ecology, Osaka Metropolitan University , 2-1-132 Morinomiya, Joto-ku, Osaka 536-8525 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoko","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Graduate School of Human Life and Ecology, Osaka Metropolitan University , 2-1-132 Morinomiya, Joto-ku, Osaka 536-8525 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Kananiwa","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Graduate School of Human Life and Ecology, Osaka Metropolitan University , 2-1-132 Morinomiya, Joto-ku, Osaka 536-8525 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Medical Science, Graduate School of Medicine, Osaka Metropolitan University , 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Graduate School of Human Life and Ecology, Osaka Metropolitan University , 2-1-132 Morinomiya, Joto-ku, Osaka 536-8525 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"2026020310572771200_ref1","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1007\/s00018-005-5369-8","article-title":"Multifunctional roles of lactoferrin: a critical overview","volume":"62","author":"Ward","year":"2005","journal-title":"Cell. 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