{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:46:03Z","timestamp":1793832363643,"version":"4.6.1"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"a grant from Lotte foundation"},{"name":"a Samuro Kakiuchi memorial research award for young scientists from the Japanese biochemical society"},{"name":"a life science research grant from the Mitsubishi foundation"},{"name":"an Inamori research grant from the Inamori foundation"},{"name":"a Kishimoto research grant from Senri life science foundation"},{"name":"a life science continuous research grant from Takeda science foundation"},{"name":"a grant from MSD life science foundation"},{"name":"a grant for front runner of future diabetes research (FFDR) from the Japan foundation for applied enzymology","award":["17F005"],"award-info":[{"award-number":["17F005"]}]},{"name":"JSPS KAKENHI grant-in-aid for scientific research","award":["25\u00a0K03025"],"award-info":[{"award-number":["25\u00a0K03025"]}]},{"name":"a grant from the Japan Agency for Medical research and Development","award":["25ek0210204h0002"],"award-info":[{"award-number":["25ek0210204h0002"]}]},{"name":"Japan Science and Technology Agency (JST) Fusion Oriented Research for disruptive Science and Technology (FOREST) Program","award":["JPMJFR245I"],"award-info":[{"award-number":["JPMJFR245I"]}]},{"name":"a grant from Pharmacological Research Foundation"},{"name":"a grant from Mishima Kaiun Memorial Foundation"},{"name":"by a grant from MSD life science foundation"},{"name":"Japan society for the promotion of science (JSPS) KAKENHI grant-in-aid for early-career scientists","award":["24\u00a0K19301"],"award-info":[{"award-number":["24\u00a0K19301"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A growing body of evidence indicates that circadian dysregulation\u2014caused by lifestyle factors, such as short sleep, irregular sleep patterns and shift work\u2014constitutes an independent risk factor for insulin resistance, obesity and diabetes. Mammalian circadian rhythms are orchestrated by a conserved transcription\u2013translation feedback loop driven by core transcription factors, which also regulate metabolism-related genes in a tissue-specific manner. Moreover, feeding behaviour and physical activity influence the circadian clock, highlighting a reciprocal relationship between the clock and metabolism. In this review, we discuss circadian regulation of key metabolic organs\u2014including pancreatic \u03b2 cells, skeletal muscle, liver and adipose tissue\u2014with a focus on molecular metabolisms, and we also highlight relevant human studies to explore the therapeutic potential of targeting the circadian clock. Further investigation into the interplay between the circadian clock and metabolism holds promise for uncovering novel mechanisms and identifying innovative strategies to restore or enhance metabolic homeostasis.<\/jats:p>","DOI":"10.1093\/jb\/mvaf084","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T12:42:12Z","timestamp":1766839332000},"page":"231-239","source":"Crossref","is-referenced-by-count":7,"title":["Circadian regulation of metabolic homeostasis in physiology and disease"],"prefix":"10.1093","volume":"179","author":[{"given":"Kaede","family":"Saito","sequence":"first","affiliation":[{"name":"Division for Health Service Promotion, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimasa","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9799-7975","authenticated-orcid":false,"given":"Yuta","family":"Hiraike","sequence":"additional","affiliation":[{"name":"Division for Health Service Promotion, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 ,","place":["Japan"]},{"name":"Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 ,","place":["Japan"]},{"name":"Laboratory for Advanced Research on Pathophysiology of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"2026040911511543400_ref1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2337\/dc14-2073","article-title":"Sleep duration and risk of type 2 diabetes: a meta-analysis of prospective studies","volume":"38","author":"Shan","year":"2015","journal-title":"Diabetes Care"},{"key":"2026040911511543400_ref2","doi-asserted-by":"crossref","first-page":"380","DOI":"10.2337\/diacare.26.2.380","article-title":"A prospective study of self-reported sleep duration and incident diabetes in women","volume":"26","author":"Ayas","year":"2003","journal-title":"Diabetes Care"},{"key":"2026040911511543400_ref3","doi-asserted-by":"crossref","first-page":"762","DOI":"10.2337\/dc17-1933","article-title":"Night shift work, genetic risk, and type 2 diabetes in the UK biobank","volume":"41","author":"Vetter","year":"2018","journal-title":"Diabetes Care"},{"key":"2026040911511543400_ref4","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/S0140-6736(99)01376-8","article-title":"Impact of sleep debt on metabolic and endocrine function","volume":"354","author":"Spiegel","year":"1999","journal-title":"Lancet"},{"key":"2026040911511543400_ref5","doi-asserted-by":"crossref","first-page":"129ra43","DOI":"10.1126\/scitranslmed.3003200","article-title":"Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption","volume":"4","author":"Buxton","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"2026040911511543400_ref6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1001\/archinte.163.2.205","article-title":"A prospective study of sleep duration and coronary heart disease in women","volume":"163","author":"Ayas","year":"2003","journal-title":"Arch. Intern. Med."},{"key":"2026040911511543400_ref7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/aje\/kwj185","article-title":"A prospective cohort study of shift work and risk of ischemic heart disease in Japanese male workers","volume":"164","author":"Fujino","year":"2006","journal-title":"Am. J. Epidemiol."},{"key":"2026040911511543400_ref8","doi-asserted-by":"crossref","first-page":"829","DOI":"10.5665\/sleep.4684","article-title":"Trends in self-reported sleep duration among US adults from 1985 to 2012","volume":"38","author":"Ford","year":"2015","journal-title":"Sleep"},{"key":"2026040911511543400_ref9","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nrg.2016.150","article-title":"Transcriptional architecture of the mammalian circadian clock","volume":"18","author":"Takahashi","year":"2017","journal-title":"Nat Rev Genet"},{"key":"2026040911511543400_ref10","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nature00906","article-title":"A transcription factor response element for gene expression during circadian night","volume":"418","author":"Ueda","year":"2002","journal-title":"Nature"},{"key":"2026040911511543400_ref11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0092-8674(02)00825-5","article-title":"The orphan nuclear receptor REV-ERB\u03b1 controls circadian transcription within the positive limb of the mammalian circadian oscillator","volume":"110","author":"Preitner","year":"2002","journal-title":"Cell"},{"key":"2026040911511543400_ref12","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1126\/science.aab3021","article-title":"Discrete functions of nuclear receptor Rev\u2013erb\u03b1 couple metabolism to the clock","volume":"348","author":"Zhang","year":"2015","journal-title":"Science"},{"key":"2026040911511543400_ref13","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1101\/gad.281972.116","article-title":"HNF6 and Rev\u2013erb\u03b1 integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms","volume":"30","author":"Zhang","year":"2016","journal-title":"Genes Dev."},{"key":"2026040911511543400_ref14","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nsmb.1860","article-title":"Structure of Rev\u2013erb\u03b1 bound to N-CoR reveals a unique mechanism of nuclear receptor\u2013co-repressor interaction","volume":"17","author":"Phelan","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2026040911511543400_ref15","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.1074\/jbc.M110.193466","article-title":"Thiol-disulfide redox dependence of heme binding and heme ligand switching in nuclear hormone receptor Rev\u2013erb\u03b2","volume":"286","author":"Gupta","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2026040911511543400_ref16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.molcel.2012.08.012","article-title":"Circadian Dbp transcription relies on highly dynamic BMAL1\u2013CLOCK interaction with E boxes and requires the proteasome","volume":"48","author":"Stratmann","year":"2012","journal-title":"Mol. Cell"},{"key":"2026040911511543400_ref17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1101\/gad.14.6.679","article-title":"CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP","volume":"14","author":"Ripperger","year":"2000","journal-title":"Genes Dev."},{"key":"2026040911511543400_ref18","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cmet.2007.09.006","article-title":"High-fat diet disrupts behavioral and molecular circadian rhythms in mice","volume":"6","author":"Kohsaka","year":"2007","journal-title":"Cell Metab."},{"key":"2026040911511543400_ref19","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.1108750","article-title":"Obesity and metabolic syndrome in circadian clock mutant mice","volume":"308","author":"Turek","year":"2005","journal-title":"Science"},{"key":"2026040911511543400_ref20","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF00427978","article-title":"Circadian variations of blood sugar and plasma insulin levels in man","volume":"5","author":"Malherbe","year":"1969","journal-title":"Diabetologia"},{"key":"2026040911511543400_ref21","doi-asserted-by":"crossref","first-page":"4426","DOI":"10.1210\/en.2015-1516","article-title":"Circadian disruption and diet-induced obesity synergize to promote development of \u03b2-cell failure and diabetes in male rats","volume":"156","author":"Qian","year":"2015","journal-title":"Endocrinology"},{"key":"2026040911511543400_ref22","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature09253","article-title":"Disruption of the CLOCK components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes","volume":"466","author":"Marcheva","year":"2010","journal-title":"Nature"},{"key":"2026040911511543400_ref23","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s00125-010-1920-8","article-title":"An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice","volume":"54","author":"Sadacca","year":"2011","journal-title":"Diabetologia"},{"key":"2026040911511543400_ref24","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1128\/MCB.01421-12","article-title":"Bmal1 and \u03b2-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced \u03b2-cell failure in mice","volume":"33","author":"Lee","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"2026040911511543400_ref25","doi-asserted-by":"crossref","first-page":"381","DOI":"10.4161\/isl.3.6.18157","article-title":"Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in \u03b2-cells","volume":"3","author":"Lee","year":"2011","journal-title":"Islets"},{"key":"2026040911511543400_ref26","doi-asserted-by":"crossref","first-page":"aac4250","DOI":"10.1126\/science.aac4250","article-title":"Pancreatic \u03b2 cell enhancers regulate rhythmic transcription of genes controlling insulin secretion","volume":"350","author":"Perelis","year":"2015","journal-title":"Science"},{"key":"2026040911511543400_ref27","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.molmet.2017.04.008","article-title":"Uncoupling protein 2 regulates daily rhythms of insulin secretion capacity in MIN6 cells and isolated islets from male mice","volume":"6","author":"Seshadri","year":"2017","journal-title":"Mol Metab"},{"key":"2026040911511543400_ref28","doi-asserted-by":"crossref","first-page":"S157","DOI":"10.2337\/dc09-S302","article-title":"Skeletal muscle insulin resistance is the primary defect in type 2 diabetes","volume":"32","author":"DeFronzo","year":"2009","journal-title":"Diabetes Care"},{"key":"2026040911511543400_ref29","doi-asserted-by":"crossref","first-page":"eaao0318","DOI":"10.1126\/science.aao0318","article-title":"Diurnal transcriptome atlas of a primate across major neural and peripheral tissues","volume":"359","author":"Mure","year":"2018","journal-title":"Science"},{"key":"2026040911511543400_ref30","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cmet.2016.09.010","article-title":"Circadian clock interaction with HIF1\u03b1 mediates oxygenic metabolism and anaerobic glycolysis in skeletal muscle","volume":"25","author":"Peek","year":"2017","journal-title":"Cell Metab."},{"key":"2026040911511543400_ref31","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2024.101980","article-title":"Skeletal muscle BMAL1 is necessary for transcriptional adaptation of local and peripheral tissues in response to endurance exercise training","volume":"86","author":"Viggars","year":"2024","journal-title":"Mol Metab"},{"key":"2026040911511543400_ref32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2005886","article-title":"Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock","volume":"16","author":"Dyar","year":"2018","journal-title":"PLoS Biol."},{"key":"2026040911511543400_ref33","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.cub.2014.12.036","article-title":"The impact of circadian phenotype and time since awakening on diurnal performance in athletes","volume":"25","author":"Facer-Childs","year":"2015","journal-title":"Curr. Biol."},{"key":"2026040911511543400_ref34","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41574-018-0150-x","article-title":"Circadian rhythms and exercise\u2014re-setting the clock in metabolic disease","volume":"15","author":"Gabriel","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"2026040911511543400_ref35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1126\/science.1172156","article-title":"AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation","volume":"326","author":"Lamia","year":"2009","journal-title":"Science"},{"key":"2026040911511543400_ref36","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/hep.29878","article-title":"The hepatic BMAL1\/AKT\/lipogenesis axis protects against alcoholic liver disease in mice via promoting PPAR\u03b1 pathway","volume":"68","author":"Zhang","year":"2018","journal-title":"Hepatology"},{"key":"2026040911511543400_ref37","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.cell.2018.06.031","article-title":"Diet-induced circadian enhancer remodeling synchronizes opposing hepatic lipid metabolic processes","volume":"174","author":"Guan","year":"2018","journal-title":"Cell"},{"key":"2026040911511543400_ref38","doi-asserted-by":"crossref","first-page":"21453","DOI":"10.1073\/pnas.0909591106","article-title":"Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression","volume":"106","author":"Vollmers","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2026040911511543400_ref39","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1126\/science.abl8007","article-title":"Time-restricted feeding mitigates obesity through adipocyte thermogenesis","volume":"378","author":"Hepler","year":"2022","journal-title":"Science"},{"key":"2026040911511543400_ref40","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1101\/gad.350759.123","article-title":"Circadian mechanisms in adipose tissue bioenergetics and plasticity","volume":"37","author":"Hepler","year":"2023","journal-title":"Genes Dev."},{"key":"2026040911511543400_ref41","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/0092-8674(94)90006-X","article-title":"Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor","volume":"79","author":"Tontonoz","year":"1994","journal-title":"Cell"},{"key":"2026040911511543400_ref42","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1097-2765(00)80211-7","article-title":"PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro","volume":"4","author":"Rosen","year":"1999","journal-title":"Mol. Cell"},{"key":"2026040911511543400_ref43","doi-asserted-by":"crossref","first-page":"16265","DOI":"10.1016\/S0021-9258(19)85415-7","article-title":"Induction of rev-ErbA alpha, an orphan receptor encoded on the opposite strand of the alpha-thyroid hormone receptor gene, during adipocyte differentiation","volume":"268","author":"Chawla","year":"1993","journal-title":"J. Biol. Chem."},{"key":"2026040911511543400_ref44","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1126\/science.1252079","article-title":"Controlling low rates of cell differentiation through noise and ultrahigh feedback","volume":"344","author":"Ahrends","year":"2014","journal-title":"Science"},{"key":"2026040911511543400_ref45","article-title":"The circadian clock mediates daily bursts of cell differentiation by periodically restricting cell-differentiation commitment","volume":"119","author":"Zhang","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2026040911511543400_ref46","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1038\/nm.2979","article-title":"Obesity in mice with adipocyte-specific deletion of clock component Arntl","volume":"18","author":"Paschos","year":"2012","journal-title":"Nat. Med."},{"key":"2026040911511543400_ref47","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nature07182","article-title":"PRDM16 controls a brown fat\/skeletal muscle switch","volume":"454","author":"Seale","year":"2008","journal-title":"Nature"},{"key":"2026040911511543400_ref48","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1172\/JCI44271","article-title":"Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice","volume":"121","author":"Seale","year":"2011","journal-title":"J. Clin. Invest."},{"key":"2026040911511543400_ref49","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nature12652","article-title":"EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex","volume":"504","author":"Ohno","year":"2013","journal-title":"Nature"},{"key":"2026040911511543400_ref50","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cmet.2013.01.015","article-title":"EBF2 determines and maintains brown adipocyte identity","volume":"17","author":"Rajakumari","year":"2013","journal-title":"Cell Metab."},{"key":"2026040911511543400_ref51","doi-asserted-by":"crossref","first-page":"14466","DOI":"10.1073\/pnas.1412685111","article-title":"Ebf2 is a selective marker of brown and beige adipogenic precursor cells","volume":"111","author":"Wang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026040911511543400_ref52","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1101\/gad.294405.116","article-title":"EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex","volume":"31","author":"Shapira","year":"2017","journal-title":"Genes Dev."},{"key":"2026040911511543400_ref53","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/ncb3590","article-title":"NFIA co-localizes with PPAR\u03b3 and transcriptionally controls the brown fat gene program","volume":"19","author":"Hiraike","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"2026040911511543400_ref54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009044","article-title":"NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure brown and beige adipocyte differentiation","volume":"16","author":"Hiraike","year":"2020","journal-title":"PLoS Genet."},{"key":"2026040911511543400_ref55","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104729","article-title":"NFIA determines the cis-effect of genetic variation on Ucp1 expression in murine thermogenic adipocytes","volume":"25","author":"Hiraike","year":"2022","journal-title":"iScience"},{"key":"2026040911511543400_ref56","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2308750120","article-title":"NFIA in adipocytes reciprocally regulates mitochondrial and inflammatory gene program to improve glucose homeostasis","volume":"120","author":"Hiraike","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026040911511543400_ref57","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/jb\/mvaf038","article-title":"Transcriptional control of brown adipocyte differentiation and function by NFIA: recent perspectives on deciphering metabolic diseases","volume":"178","author":"Hiraike","year":"2025","journal-title":"J. Biochem."},{"key":"2026040911511543400_ref58","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nature12642","article-title":"The nuclear receptor Rev\u2013erb\u03b1 controls circadian thermogenic plasticity","volume":"503","author":"Gerhart-Hines","year":"2013","journal-title":"Nature"},{"key":"2026040911511543400_ref59","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1038\/oby.2011.125","article-title":"Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans","volume":"19","author":"Yoneshiro","year":"2011","journal-title":"Obesity (Silver Spring)"},{"key":"2026040911511543400_ref60","doi-asserted-by":"crossref","first-page":"7734","DOI":"10.18632\/aging.204318","article-title":"Aging attenuates diurnal lipid uptake by brown adipose tissue","volume":"14","author":"In Het Panhuis","year":"2022","journal-title":"Aging"},{"key":"2026040911511543400_ref61","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1101\/gad.319228.118","article-title":"Requirement for NF-\u03baB in maintenance of molecular and behavioral circadian rhythms in mice","volume":"32","author":"Hong","year":"2018","journal-title":"Genes Dev."},{"key":"2026040911511543400_ref62","doi-asserted-by":"crossref","first-page":"12662","DOI":"10.1073\/pnas.1209965109","article-title":"Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines","volume":"109","author":"Narasimamurthy","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2026040911511543400_ref63","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nature12209","article-title":"Rev\u2013Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription","volume":"498","author":"Lam","year":"2013","journal-title":"Nature"},{"key":"2026040911511543400_ref64","doi-asserted-by":"crossref","first-page":"707","DOI":"10.5665\/sleep.4660","article-title":"Beneficial impact of sleep extension on fasting insulin sensitivity in adults with habitual sleep restriction","volume":"38","author":"Leproult","year":"2015","journal-title":"Sleep"},{"key":"2026040911511543400_ref65","doi-asserted-by":"crossref","first-page":"711","DOI":"10.5664\/jcsm.7758","article-title":"Effects of two-week sleep extension on glucose metabolism in chronically sleep-deprived individuals","volume":"15","author":"So-ngern","year":"2019","journal-title":"J. Clin. Sleep Med."},{"key":"2026040911511543400_ref66","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1164\/ajrccm.165.5.2103001","article-title":"Obstructive sleep apnea is independently associated with insulin resistance","volume":"165","author":"Ip","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026040911511543400_ref67","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1164\/rccm.201510-1942OC","article-title":"Effect of continuous positive airway pressure on glycemic control in patients with obstructive sleep apnea and type 2 diabetes. A randomized clinical trial","volume":"194","author":"Mart\u00ednez-Cer\u00f3n","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026040911511543400_ref68","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/dom.12823","article-title":"Effect of one week of CPAP treatment of obstructive sleep apnoea on 24-hour profiles of glucose, insulin and counter-regulatory hormones in type 2 diabetes","volume":"19","author":"Mokhlesi","year":"2017","journal-title":"Diabetes Obes. Metab."},{"key":"2026040911511543400_ref69","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejim.2016.11.010","article-title":"Continuous positive airway pressure and diabetes risk in sleep apnea patients: a systemic review and meta-analysis","volume":"39","author":"Chen","year":"2017","journal-title":"Eur J Intern Med"},{"key":"2026040911511543400_ref70","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cmet.2015.09.005","article-title":"A smartphone app reveals erratic diurnal eating patterns in humans that can be modulated for health benefits","volume":"22","author":"Gill","year":"2015","journal-title":"Cell Metab."},{"key":"2026040911511543400_ref71","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.cmet.2018.04.010","article-title":"Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes","volume":"27","author":"Sutton","year":"2018","journal-title":"Cell Metab."},{"key":"2026040911511543400_ref72","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nature11030","article-title":"Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists","volume":"485","author":"Solt","year":"2012","journal-title":"Nature"}],"container-title":["The Journal of Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jb\/advance-article-pdf\/doi\/10.1093\/jb\/mvaf084\/66149387\/mvaf084.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jb\/article-pdf\/179\/4\/231\/66149387\/mvaf084.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jb\/article-pdf\/179\/4\/231\/66149387\/mvaf084.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T15:51:34Z","timestamp":1775749894000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jb\/article\/179\/4\/231\/8407082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,30]]},"references-count":72,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12,30]]},"published-print":{"date-parts":[[2026,4,13]]}},"URL":"https:\/\/doi.org\/10.1093\/jb\/mvaf084","relation":{},"ISSN":["0021-924X","1756-2651"],"issn-type":[{"value":"0021-924X","type":"print"},{"value":"1756-2651","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2025,12,30]]}}}