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Cellular senescence, particularly the senescence-associated secretory phenotype (SASP), contributes to delayed healing by inducing persistent inflammation and dysfunction in dermal fibroblasts, macrophages and adipose tissue cells. Here, we review the molecular pathways leading to senescence in these cell types, including p53\/p21 activation and apoptosis resistance, and how their SASP perpetuates chronic inflammation and impairs tissue regeneration. We also discuss emerging therapeutic approaches targeting senescent cells with senolytic and senomorphic agents to improve healing outcomes. These insights suggest that modulating cellular senescence may offer promising avenues for treating diabetic wounds, warranting further investigation into senescence-targeted therapies in clinical settings.<\/jats:p>","DOI":"10.1093\/jb\/mvag006","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:27:12Z","timestamp":1769506032000},"page":"241-248","source":"Crossref","is-referenced-by-count":4,"title":["The role of cellular senescence in wound healing of diabetic skin"],"prefix":"10.1093","volume":"179","author":[{"given":"Naohiro","family":"Ueda","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Sapporo Medical University School of Medicine , South 1 West 17, Chuo-ku, Sapporo, Hokkaido 060-8556 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7949-1628","authenticated-orcid":false,"given":"Yuki","family":"Saito","sequence":"additional","affiliation":[{"name":"Graduate School of Health and Medical Sciences, Sapporo Medical University , South 1 West 17, Chuo-ku, Sapporo, Hokkaido 060-8556 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Ota","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Hokkaido University , North 12 West 5, Kita-ku, Sapporo, Hokkaido 060-0812 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Nagao","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Hokkaido University , North 12 West 5, Kita-ku, Sapporo, Hokkaido 060-0812 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dain","family":"Kasseki","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Hokkaido University , North 12 West 5, Kita-ku, Sapporo, Hokkaido 060-0812 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2832-3656","authenticated-orcid":false,"given":"Takako S","family":"Chikenji","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Hokkaido University , North 12 West 5, Kita-ku, Sapporo, Hokkaido 060-0812 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"2026040911510452000_ref1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0140-6736(23)02750-2","article-title":"Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults","volume":"403","author":"NCD Risk Factor Collaboration (NCD-RisC)","year":"2024","journal-title":"Lancet."},{"key":"2026040911510452000_ref2","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation","year":"2025","edition":"11th"},{"key":"2026040911510452000_ref3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2023.10578","article-title":"Diabetic foot ulcers: a review","volume":"330","author":"Armstrong","year":"2023","journal-title":"JAMA."},{"key":"2026040911510452000_ref4","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/iwj.12932","article-title":"Diabetic foot infection: a critical complication","volume":"15","author":"Hurlow","year":"2018","journal-title":"Int. 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