{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:31:12Z","timestamp":1783017072901,"version":"3.54.6"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"The Medical Research Support Centre and Innovative Support Alliance for Life Science core facility at Kyoto University was supported in part by the AMED","award":["JP22ama121034"],"award-info":[{"award-number":["JP22ama121034"]}]},{"name":"the Kyoto University LiMe Office of Directors\u2019 Research Grants Program"},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23jm0210106"],"award-info":[{"award-number":["JP23jm0210106"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["21cm0106171h0002 and 25ym0126808j0004"],"award-info":[{"award-number":["21cm0106171h0002 and 25ym0126808j0004"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and technology Agency","doi-asserted-by":"publisher","award":["JPMJMS2022 and JPMJCR2572"],"award-info":[{"award-number":["JPMJMS2022 and JPMJCR2572"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japan Society for the Promotion of Science (JSPS)\/the Ministry of Education, Culture, Sports, Science and Technology","award":["17\u00a0K20148, 21H05048, and 24\u00a0K22069"],"award-info":[{"award-number":["17\u00a0K20148, 21H05048, and 24\u00a0K22069"]}]},{"name":"Japan Society for the Promotion of Science (JSPS)\/the Ministry of Education, Culture, Sports, Science and Technology","award":["25H01433"],"award-info":[{"award-number":["25H01433"]}]},{"name":"Japan Society for the Promotion of Science (JSPS)\/the Ministry of Education, Culture, Sports, Science and Technology","award":["23\u00a0K24363"],"award-info":[{"award-number":["23\u00a0K24363"]}]},{"name":"Japan Society for the Promotion of Science (JSPS)\/the Ministry of Education, Culture, Sports, Science and Technology","award":["23\u00a0K14354"],"award-info":[{"award-number":["23\u00a0K14354"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic myeloid leukaemia (CML) is a hematologic malignancy originating from hematopoietic stem cells with the fusion oncogene BCR\u2013ABL1 on the Philadelphia chromosome, which drives the abnormal proliferation of leukemic blast cells within the bone marrow microenvironment. While previous research has primarily focused on the hematopoietic compartment, the functional contribution of the bone marrow microenvironment to the CML pathology remains understudied. We investigated the changes in the peripheral nervous system in the bone marrow with myeloid leukaemia via immunofluorescence staining of tyrosine hydroxylase (TH) and calcitonin gene-related peptide (CGRP) antibodies in mouse with NUP98\u2013HOXA9\u2013 and BCR\u2013ABL1\u2013expressing myeloid leukaemia. We found that the TH-positive fibres were significantly reduced, while no overt changes were observed in CGRP-positive nerves in the bone marrow. The reduction in TH-positive nerve cells was also evident in the spleen. Human patient gene expression data suggested that the levels of sympathetic nerve receptor expression change during the blastic transformation of human CML. Our findings indicate that the sympathetic nervous system regulates the pathogenesis of myeloid leukaemia and could play a crucial role in the disease progression of myeloid leukaemia.<\/jats:p>","DOI":"10.1093\/jb\/mvag028","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:49:57Z","timestamp":1775735397000},"page":"75-82","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic changes of the sympathetic nervous system in the bone marrow in myeloid leukaemia"],"prefix":"10.1093","volume":"180","author":[{"given":"Sayumi","family":"Okigawa","sequence":"first","affiliation":[{"name":"The Institute for Life and Medical Sciences, Kyoto University , Shogoin Kawaharacho 53, Sakyo, Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hibiki","family":"Inafuku","sequence":"additional","affiliation":[{"name":"The Institute for Life and Medical Sciences, Kyoto University , Shogoin Kawaharacho 53, Sakyo, Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayuna","family":"Hattori","sequence":"additional","affiliation":[{"name":"The Institute for Life and Medical Sciences, Kyoto University , Shogoin Kawaharacho 53, Sakyo, Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-0412","authenticated-orcid":false,"given":"Takahiro","family":"Ito","sequence":"additional","affiliation":[{"name":"The Institute for Life and Medical Sciences, Kyoto University , Shogoin Kawaharacho 53, Sakyo, Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"2026070213220792800_ref1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12185-017-2262-9","article-title":"Complexity of bone marrow hematopoietic stem cell niche","volume":"106","author":"Asada","year":"2017","journal-title":"Int. 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