{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:31:59Z","timestamp":1793158319025,"version":"4.5.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Sojo University Research Priority","id":[{"id":"https:\/\/ror.org\/014fz7968","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","award":["19K12340"],"award-info":[{"award-number":["19K12340"]}],"id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","award":["JP15K00557"],"award-info":[{"award-number":["JP15K00557"]}],"id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","award":["JP25740024"],"award-info":[{"award-number":["JP25740024"]}],"id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Estrogen-related receptor \u03b3 (ERR\u03b3) is an orphan nuclear receptor whose molecular functions in transcriptional regulation remain incompletely understood. The androgen receptor (AR) is a ligand-dependent transcription factor that plays a pivotal role in prostate cancer (PCa) by regulating gene expression through androgen-response elements. Its activity is tightly controlled by receptor conformation and coactivator recruitment. Although ERR\u03b3 has been implicated in the suppression of PCa progression, whether it modulates AR signalling remains unclear. In this study, we examined the functional and molecular interplay between ERR\u03b3 and AR using a heterologous expression system in HeLa cells. We found that ERR\u03b3 suppresses AR-mediated transcriptional activation in a dose-dependent manner on androgen response element (ARE)-containing promoters. Mechanistically, ERR\u03b3 interacted with the ligand-activated AR in the nucleus and disrupted the intramolecular interaction between the N-terminal domain and the C-terminal ligand-binding domain, which is required for full receptor activation. This interference did not affect AR nuclear translocation. Furthermore, ERR\u03b3 functionally competed with major transcriptional coactivators, including steroid receptor coactivators-3 and p300, thereby attenuating coactivator-enhanced AR-dependent transcription. Collectively, these findings demonstrate that ERR\u03b3 functions as a novel corepressor of AR by destabilizing receptor conformation and blocking coactivator recruitment, providing new mechanistic insight into the regulation of AR-mediated transcription.<\/jats:p>","DOI":"10.1093\/jb\/mvag049","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:34:29Z","timestamp":1782826469000},"page":"377-387","source":"Crossref","is-referenced-by-count":0,"title":["Estrogen-related receptor \u03b3 functions as a novel corepressor of androgen receptor by destabilizing receptor conformation and blocking coactivator recruitment"],"prefix":"10.1093","volume":"180","author":[{"given":"Xiaohui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Life Sciences, Faculty of Biotechnology and Life Sciences, Sojo University , 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisei","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Life Sciences, Faculty of Biotechnology and Life Sciences, Sojo University , 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Life Sciences, Faculty of Biotechnology and Life Sciences, Sojo University , 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manato","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Life Sciences, Faculty of Biotechnology and Life Sciences, Sojo University , 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Yasukochi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Life Sciences, Faculty of Biotechnology and Life Sciences, Sojo University , 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Nagahama","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Life Sciences, Faculty of Biotechnology and Life Sciences, Sojo University , 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"2026102722320584000_ref1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1210\/er.2008-0017","article-title":"Transcriptional control of energy homeostasis by the estrogen-related receptors","volume":"29","author":"Gigu\u00e8re","year":"2008","journal-title":"Endocr. 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