{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:01:59Z","timestamp":1787731319953,"version":"build-2784847793"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Idiopathic normal pressure hydrocephalus (iNPH) is a dementia-inducing disorder. Primary cause of iNPH is speculated to be a reduction of cerebrospinal fluid (CSF) absorption, which secondarily induces hydrocephalus, compression of brain, and reduction of CSF production. Patients are treated by surgically inserting a shunt to deliver excess CSF to the abdominal cavity. The prognosis for cognitive improvement after shunt surgery has been difficult to predict. We therefore investigated various CSF proteins, hoping to find a biomarker predictive of cognitive performance one to two years after shunt surgery. CSF proteins of 34 iNPH and 15 non-iNPH patients were analysed by Western blotting, revealing two glycan isoforms of transferrin (Tf); \u2018brain-type\u2019 Tf with N-acetylglucosaminylated glycans and \u2018serum-type\u2019 Tf with \u03b12, 6-sialylated glycans. Brain-type Tf levels decreased in iNPH but rapidly returned to normal levels within 1\u20133 months after shunt surgery. This change was positively correlated with recovery from dementia, per Mini-Mental State Examination and Frontal Assessment Battery scores at 11.8 \u00b1 7.7 months post-operation, suggesting that brain-type Tf is a prognostic marker for recovery from dementia after shunt surgery for iNPH. Histochemical staining with anti-Tf antibody and an N-acetylglucosamine-binding lectin suggests that brain-type Tf is secreted from choroid plexus, CSF-producing tissue.<\/jats:p>","DOI":"10.1093\/jb\/mvy043","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T02:49:45Z","timestamp":1524538185000},"page":"205-213","source":"Crossref","is-referenced-by-count":21,"title":["Rapid increase of \u2018brain-type\u2019 transferrin in cerebrospinal fluid after shunt surgery for idiopathic normal pressure hydrocephalus: a prognosis marker for cognitive recovery"],"prefix":"10.1093","volume":"164","author":[{"given":"Yuta","family":"Murakami","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery, Fukushima Medical University, Fukushima City, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Fukushima Medical University, Fukushima City, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoka","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Biochemistry, Fukushima Medical University, Fukushima City, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Ito","sequence":"additional","affiliation":[{"name":"Biochemistry, Fukushima Medical University, Fukushima City, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi J","family":"Fuwa","sequence":"additional","affiliation":[{"name":"Biochemistry, Fukushima Medical University, Fukushima City, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Structural Glycobiology Team, Systems Glycobiology Research Group, RIKEN-Max Planck Joint Research Center, RIKEN Global Research Cluster, Wako, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madoka","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Miyajima","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Nollet","sequence":"additional","affiliation":[{"name":"Departments of Blood Transfusion and Transplantation Immunology, Fukushima Medical University, Fukushima City, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naho","family":"Kato","sequence":"additional","affiliation":[{"name":"Forensic Medicine, Fukushima Medical University, Fukushima City, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Nishikata","sequence":"additional","affiliation":[{"name":"Forensic Medicine, Fukushima Medical University, Fukushima City, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohito","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Forensic Medicine, Fukushima Medical University, Fukushima City, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Honda","sequence":"additional","affiliation":[{"name":"Human Life Science, Fukushima Medical University, Fukushima City, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Fukushima Medical University, Fukushima City, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Fukushima Medical University, Fukushima City, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Biochemistry, Fukushima Medical University, Fukushima City, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"key":"2026041420065455600_mvy043-B1","first-page":"1","article-title":"Studies on the cerebro-spinal fluid: I. Introduction","volume":"31","author":"Cushing","year":"1914","journal-title":"J. Med. Res."},{"key":"2026041420065455600_mvy043-B2","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/brain\/91.4.707","article-title":"Formation and absorption of cerebrospinal fluid in man","volume":"91","author":"Cutler","year":"1968","journal-title":"Brain"},{"key":"2026041420065455600_mvy043-B3","volume-title":"Selected Papers on Neurosurgery","author":"Cushing","year":"1969"},{"key":"2026041420065455600_mvy043-B4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbi.2013.10.012","article-title":"Afferent and efferent immunological pathways of the brain. Anatomy, function and failure","volume":"36","author":"Carare","year":"2014","journal-title":"Brain Behav. Immun"},{"key":"2026041420065455600_mvy043-B5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1743-8454-7-15","article-title":"Aquaporins: relevance to cerebrospinal fluid physiology and therapeutic potential in hydrocephalus","volume":"7","author":"Owler","year":"2010","journal-title":"Cerebrospinal Fluid Res"},{"key":"2026041420065455600_mvy043-B6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/jnnp.13.3.203","article-title":"The penetration of particulate matter from the cerebrospinal fluid into the spinal ganglia, peripheral nerves, and perivascular spaces of the central nervous system","volume":"13","author":"Brierley","year":"1950","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"2026041420065455600_mvy043-B7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1679\/aohc.61.277","article-title":"Lymphatic drainage of the cerebrospinal fluid from monkey spinal meninges with special reference to the distribution of the epidural lymphatics","volume":"61","author":"Miura","year":"1998","journal-title":"Arch. Histol. Cytol"},{"key":"2026041420065455600_mvy043-B8","first-page":"694","article-title":"Latest knowledge of cerebrospinal fluid: production, circulation and absorption with specialreference to the collateral absorptive routes via the epidural lymphatic system","volume":"28","author":"Miura","year":"2015","journal-title":"Spine Spinal Cord"},{"key":"2026041420065455600_mvy043-B9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1468-1331.2012.03781.x","article-title":"Soluble amyloid precursor protein alpha in the cerebrospinal fluid as a diagnostic and prognostic biomarker for idiopathic normal pressure hydrocephalus","volume":"20","author":"Miyajima","year":"2013","journal-title":"Eur. J. Neurol."},{"key":"2026041420065455600_mvy043-B10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.mehy.2006.01.029","article-title":"Theoretical considerations on the pathophysiology of normal pressure hydrocephalus (NPH) and NPH-related dementia","volume":"67","author":"Hamlat","year":"2006","journal-title":"Med. Hypotheses"},{"key":"2026041420065455600_mvy043-B11","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2176\/nmc.52.775","article-title":"Guidelines for management of idiopathic normal pressure hydrocephalus: second edition","volume":"52","author":"Mori","year":"2012","journal-title":"Neurol. Med. Chir (Tokyo)"},{"key":"2026041420065455600_mvy043-B12","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1212\/WNL.0000000000000342","article-title":"Prevalence of idiopathic normal-pressure hydrocephalus","volume":"82","author":"Jaraj","year":"2014","journal-title":"Neurology"},{"key":"2026041420065455600_mvy043-B13","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/ncpneuro0237","article-title":"The diagnosis and treatment of idiopathic normal pressure hydrocephalus","volume":"2","author":"Gallia","year":"2006","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"2026041420065455600_mvy043-B14","doi-asserted-by":"crossref","first-page":"S2-4","DOI":"10.1227\/01.NEU.0000168185.29659.C5","article-title":"Diagnosing idiopathic normal-pressure hydrocephalus","volume":"57","author":"Relkin","year":"2005","journal-title":"Neurosurgery"},{"key":"2026041420065455600_mvy043-B15","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S1474-4422(15)00046-0","article-title":"Lumboperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (SINPHONI-2): an open-label randomised trial","volume":"14","author":"Kazui","year":"2015","journal-title":"Lancet Neurol"},{"key":"2026041420065455600_mvy043-B16","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1743-8454-7-18","article-title":"Diagnosis of idiopathic normal pressure hydrocephalus is supported by MRI-based scheme: a prospective cohort study","volume":"7","author":"Hashimoto","year":"2010","journal-title":"Cerebrospinal Fluid Res"},{"key":"2026041420065455600_mvy043-B17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/3-211-30714-1_78","article-title":"Clinical outcome of patients with idiopathic normal pressure hydrocephalus three years after shunt implantation","volume":"96","author":"Meier","year":"2006","journal-title":"Acta Neurochir. Suppl"},{"key":"2026041420065455600_mvy043-B18","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1136\/jnnp.2007.123620","article-title":"Normal pressure hydrocephalus: long-term outcome after shunt surgery","volume":"79","author":"Pujari","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"2026041420065455600_mvy043-B19","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3171\/2014.6.JNS131211","article-title":"Outcome of modern shunt therapy in patients with idiopathic normal pressure hydrocephalus 6 years postoperatively","volume":"121","author":"Golz","year":"2014","journal-title":"J. Neurosurg"},{"key":"2026041420065455600_mvy043-B20","first-page":"503","article-title":"The value of temporary external lumbar CSF drainage in predicting the outcome of shunting on normal pressure hydrocephalus","volume":"72","author":"Walchenbach","year":"2002","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"2026041420065455600_mvy043-B21","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.neurobiolaging.2011.02.023","article-title":"A unique N-glycan on human transferrin in CSF: a possible biomarker for iNPH","volume":"33","author":"Futakawa","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"2026041420065455600_mvy043-B22","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1046\/j.1471-4159.1994.63062185.x","article-title":"Carbohydrate structures of beta-trace protein from human cerebrospinal fluid: evidence for \u201cbrain-type\u201d N-glycosylation","volume":"63","author":"Hoffmann","year":"2002","journal-title":"J. Neurochem"},{"key":"2026041420065455600_mvy043-B23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.15252\/emmm.201404438","article-title":"An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer\u2019s disease","volume":"7","author":"Kizuka","year":"2015","journal-title":"EMBO Mol. Med"},{"key":"2026041420065455600_mvy043-B24","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer\u2019s disease: genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol. Rev."},{"key":"2026041420065455600_mvy043-B25","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cell.2005.02.008","article-title":"Twenty years of the Alzheimer\u2019s disease amyloid hypothesis: a genetic perspective","volume":"120","author":"Tanzi","year":"2005","journal-title":"Cell"},{"key":"2026041420065455600_mvy043-B26","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/19083","article-title":"A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain","volume":"398","author":"De Strooper","year":"1999","journal-title":"Nature"},{"key":"2026041420065455600_mvy043-B27","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1074\/jbc.273.11.6277","article-title":"Cleavage of Alzheimer\u2019s amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism","volume":"273","author":"Tomita","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2026041420065455600_mvy043-B28","doi-asserted-by":"crossref","first-page":"9513","DOI":"10.1073\/pnas.90.20.9513","article-title":"Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides","volume":"90","author":"Wertkin","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026041420065455600_mvy043-B29","doi-asserted-by":"crossref","first-page":"40817","DOI":"10.1074\/jbc.M112.398578","article-title":"Soluble amyloid precursor protein 770 is released from inflamed endothelial cells and activated platelets: a novel biomarker for acute coronary syndrome","volume":"287","author":"Kitazume","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2026041420065455600_mvy043-B30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jns.2015.07.001","article-title":"Cerebrospinal fluid biomarkers for prognosis of long-term cognitive treatment outcomes in patients with idiopathic normal pressure hydrocephalus","volume":"357","author":"Nakajima","year":"2015","journal-title":"J. Neurol. Sci"},{"key":"2026041420065455600_mvy043-B31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12987-016-0037-y","article-title":"Amyloid mis-metabolism in idiopathic normal pressure hydrocephalus","volume":"13","author":"Jeppsson","year":"2016","journal-title":"Fluids Barriers CNS"},{"key":"2026041420065455600_mvy043-B32","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2176\/nmc.44.222","article-title":"Clinical guidelines for idiopathic normal pressure hydrocephalus","volume":"44","author":"Ishikawa","year":"2004","journal-title":"Neurol. Med. Chir (Tokyo)"},{"key":"2026041420065455600_mvy043-B33","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"2026041420065455600_mvy043-B34","doi-asserted-by":"crossref","first-page":"970","DOI":"10.3171\/jns.2001.95.6.0970","article-title":"Management of idiopathic normal-pressure hydrocephalus: a multiinstitutional study conducted in Japan","volume":"95","author":"Mori","year":"2001","journal-title":"J. Neurosurg"},{"key":"2026041420065455600_mvy043-B35","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1148\/radiology.156.3.4023242","article-title":"Hydranencephaly: US appearance during in utero evolution","volume":"156","author":"Greene","year":"1985","journal-title":"Radiology"},{"key":"2026041420065455600_mvy043-B36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13052-014-0079-1","article-title":"Hydranencephaly: cerebral spinal fluid instead of cerebral mantles","volume":"40","author":"Pavone","year":"2014","journal-title":"Ital. J. Pediatr."},{"key":"2026041420065455600_mvy043-B37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0021-9258(17)31239-5","article-title":"Purification and properties of an N-acetylglucosamine-specific lectin from Psathyrella velutina mushroom","volume":"264","author":"Kochibe","year":"1989","journal-title":"J. Biol. Chem"},{"key":"2026041420065455600_mvy043-B38","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1021\/bi00378a023","article-title":"Comparative structural study of the N-linked oligosaccharides of human normal and pathological immunoglobulin G","volume":"26","author":"Takahashi","year":"1987","journal-title":"Biochemistry"},{"key":"2026041420065455600_mvy043-B39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0022-510X(00)00501-3","article-title":"Cerebrospinal fluid analysis: disease-related data patterns and evaluation programs","volume":"184","author":"Reiber","year":"2001","journal-title":"J. Neurol. Sci"},{"key":"2026041420065455600_mvy043-B40","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0006-8993(94)90807-9","article-title":"An in vivo study of the effect of 5-HT and sympathetic nerves on transferrin and transthyretin mRNA expression in rat choroid plexus and meninges","volume":"662","author":"Blay","year":"1994","journal-title":"Brain Res"},{"key":"2026041420065455600_mvy043-B41","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.febslet.2008.01.050","article-title":"Central prostaglandin D(2) stimulates food intake via the neuropeptide Y system in mice","volume":"582","author":"Ohinata","year":"2008","journal-title":"FEBS Lett"},{"key":"2026041420065455600_mvy043-B42","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S1474-4422(03)00487-3","article-title":"Alzheimer\u2019s disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis","volume":"2","author":"Silverberg","year":"2003","journal-title":"Lancet Neurol"}],"container-title":["The Journal of Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jb\/article-pdf\/164\/3\/205\/25500156\/mvy043.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jb\/article-pdf\/164\/3\/205\/25500156\/mvy043.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:12:59Z","timestamp":1776211979000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jb\/article\/164\/3\/205\/4986456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,25]]},"references-count":42,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,4,25]]},"published-print":{"date-parts":[[2018,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jb\/mvy043","relation":{},"ISSN":["0021-924X","1756-2651"],"issn-type":[{"value":"0021-924X","type":"print"},{"value":"1756-2651","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,9]]},"published":{"date-parts":[[2018,4,25]]}}}