{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:17:08Z","timestamp":1777043828727,"version":"3.51.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"DOI":"10.1093\/jb\/mvy078","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T07:09:07Z","timestamp":1537859347000},"page":"461-469","source":"Crossref","is-referenced-by-count":47,"title":["Long non-coding RNA Linc00662 promotes cell invasion and contributes to cancer stem cell-like phenotypes in lung cancer cells"],"prefix":"10.1093","volume":"164","author":[{"given":"Wenjing","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Oncology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University Institution, 20 Yudong Road, Zhifu District, Yantai, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University Institution, 20 Yudong Road, Zhifu District, Yantai, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The Affiliated Yantai Yuhuangding Hospital of Qingdao University Institution, 20 Yudong Road, Zhifu District, Yantai, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University Institution, 20 Yudong Road, Zhifu District, Yantai, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2748-7205","authenticated-orcid":false,"given":"Xiumei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University Institution, 20 Yudong Road, Zhifu District, Yantai, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,9,26]]},"reference":[{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21387","article-title":"Cancer Statistics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA Cancer J. Clin"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fonc.2017.00080","article-title":"Targeting lung cancer stem cells: research and clinical impacts","volume":"7","author":"Zakaria","year":"2017","journal-title":"Front. Oncol."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B3","first-page":"110","article-title":"Afatinib in the treatment of squamous non-small cell lung cancer: a new frontier or an old mistake?","volume":"5","author":"Lo Russo","year":"2016","journal-title":"Transl. Lung Cancer Res."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B4","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1634\/theoncologist.2015-0507","article-title":"FDA approval summary: nivolumab for the treatment of metastatic non-small cell lung cancer with progression on or after platinum-based chemotherapy","volume":"21","author":"Kazandjian","year":"2016","journal-title":"Oncologist"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1470-2045(15)00544-6","article-title":"Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study","volume":"17","author":"Antonia","year":"2016","journal-title":"Lancet Oncol"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B6","doi-asserted-by":"crossref","first-page":"e0151939","DOI":"10.1371\/journal.pone.0151939","article-title":"Clinical profile of cyclooxygenase-2 inhibitors in treating non-small cell lung cancer: a meta-analysis of nine randomized clinical trials","volume":"11","author":"Zhou","year":"2016","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12885-016-2249-6","article-title":"Mutational status of synchronous and metachronous tumor samples in patients with metastatic non-small-cell lung cancer","volume":"16","author":"Qu\u00e9r\u00e9","year":"2016","journal-title":"BMC Cancer"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B8","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/labinvest.2017.41","article-title":"The evolving concept of cancer stem-like cells in thyroid cancer and other solid tumors","volume":"97","author":"Hardin","year":"2017","journal-title":"Lab. Invest."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B9","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2174\/1574888X12666170523155846","article-title":"From stem cell biology to the treatment of lung diseases","volume":"12","author":"Esendagli","year":"2017","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrg.2015.10","article-title":"Unique features of long non-coding RNA biogenesis and function","volume":"17","author":"Quinn","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B11","doi-asserted-by":"crossref","first-page":"D193","DOI":"10.1093\/nar\/gku1173","article-title":"LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression","volume":"43","author":"Jiang","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B12","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/978-1-4939-3378-5_21","article-title":"Analyzing MiRNA-LncRNA interactions","volume":"1402","author":"Paraskevopoulou","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B13","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1159\/000453160","article-title":"A feed-forward regulatory loop between HuR and the long noncoding RNA HOTAIR promotes head and neck squamous cell carcinoma progression and metastasis","volume":"40","author":"Xu","year":"2016","journal-title":"Cell Physiol. Biochem."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3390\/cancers9040038","article-title":"Long non-coding RNAs: key regulators of epithelial-mesenchymal transition, tumour drug resistance and cancer stem cells","volume":"9","author":"Heery","year":"2017","journal-title":"Cancers (Basel)"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B15","first-page":"4","article-title":"Lin28 and let-7 in cell metabolism and cancer","volume":"4","author":"Nguyen","year":"2015","journal-title":"Transl. Pediatr."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B16","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/JTO.0b013e3181c6ed9b","article-title":"Refining the diagnosis and EGFR status of non-small cell lung carcinoma in biopsy and cytologic material, using a panel of mucin staining, TTF-1, cytokeratin 5\/6, and P63, and EGFR mutation analysis","volume":"5","author":"Nicholson","year":"2010","journal-title":"J. Thorac. Oncol"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B17","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00408-014-9636-z","article-title":"Lung cancer screening beyond low-dose computed tomography: the role of novel biomarkers","volume":"192","author":"Hasan","year":"2014","journal-title":"Lung"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12013-014-9910-y","article-title":"The clonal evolution and therapeutic approaches of lung cancer","volume":"70","author":"Yu","year":"2014","journal-title":"Cell Biochem. Biophys."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B19","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1111\/jcmm.12431","article-title":"Long non-coding RNAs in non-small cell lung cancer as biomarkers and therapeutic targets","volume":"18","author":"Chen","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B20","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1007\/s13277-015-3449-4","article-title":"Long non-coding RNA functions in lung cancer","volume":"36","author":"Sang","year":"2015","journal-title":"Tumour Biol."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B21","article-title":"Cancer stem cells: implications for cancer therapy","volume":"28","author":"Dawood","year":"2014","journal-title":"Oncology (Williston Park)"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B22","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s12013-014-9844-4","article-title":"Lung cancer stem cells and implications for future therapeutics","volume":"69","author":"Wang","year":"2014","journal-title":"Cell Biochem. Biophys."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B23","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.ctrv.2012.03.003","article-title":"Cancer stem cells: in the line of fire","volume":"38","author":"Alison","year":"2012","journal-title":"Cancer Treat. Rev."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B24","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/sj.cdd.4402283","article-title":"Identification and expansion of the tumorigenic lung cancer stem cell population","volume":"15","author":"Eramo","year":"2008","journal-title":"Cell Death Differ."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B25","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/JTO.0b013e3181d5e554","article-title":"CD24, a novel cancer biomarker, predicting disease-free survival of non-small cell lung carcinomas: a retrospective study of prognostic factor analysis from the viewpoint of forthcoming (seventh) new TNM classification","volume":"5","author":"Lee","year":"2010","journal-title":"J. Thorac. Oncol"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B26","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s12032-011-9933-9","article-title":"Aldehyde dehydrogenase-1 is a specific marker for stem cells in human lung adenocarcinoma","volume":"29","author":"Liang","year":"2012","journal-title":"Med. Oncol."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B27","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1038\/nm.2473","article-title":"A crucial requirement for Hedgehog signaling in small cell lung cancer","volume":"17","author":"Park","year":"2011","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B28","doi-asserted-by":"crossref","first-page":"22293","DOI":"10.1073\/pnas.0907781106","article-title":"Alterations of the Notch pathway in lung cancer","volume":"106","author":"Westhoff","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.bbrc.2010.01.028","article-title":"Wnt\/beta-catenin signaling regulates cancer stem cells in lung cancer A549 cells","volume":"392","author":"Teng","year":"2010","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.devcel.2013.03.002","article-title":"Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal","volume":"25","author":"Wang","year":"2013","journal-title":"Dev. Cell"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B31","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.biocel.2013.02.006","article-title":"LIN28\/LIN28B: an emerging oncogenic driver in cancer stem cells","volume":"45","author":"Zhou","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B32","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.cell.2010.02.007","article-title":"Lin28: a microRNA regulator with a macro role","volume":"140","author":"Viswanathan","year":"2010","journal-title":"Cell"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B33","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0960-9822(02)00809-6","article-title":"Identification of tissue-specific microRNAs from mouse","volume":"12","author":"Lagos-Quintana","year":"2002","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B34","doi-asserted-by":"crossref","first-page":"e10147","DOI":"10.1371\/journal.pone.0010147","article-title":"MicroRNA let-7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2","volume":"5","author":"Dong","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11010-011-0862-x","article-title":"Lin-28 reactivation is required for let-7 repression and proliferation in human small cell lung cancer cells","volume":"355","author":"Pan","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B36","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ijrobp.2009.08.028","article-title":"Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras","volume":"76","author":"Oh","year":"2010","journal-title":"Int. J. Radiat. Oncol. Biol. Phys"},{"key":"key\n\t\t\t\t2018113010250116400_mvy078-B37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.molcel.2012.08.004","article-title":"LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance","volume":"48","author":"Wilbert","year":"2012","journal-title":"Mol. Cell"}],"container-title":["The Journal of Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jb\/article-pdf\/164\/6\/461\/26916123\/mvy078.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T16:33:14Z","timestamp":1571934794000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jb\/article\/164\/6\/461\/5107023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,26]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,9,26]]},"published-print":{"date-parts":[[2018,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jb\/mvy078","relation":{},"ISSN":["0021-924X","1756-2651"],"issn-type":[{"value":"0021-924X","type":"print"},{"value":"1756-2651","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,12]]},"published":{"date-parts":[[2018,9,26]]}}}