{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:20:55Z","timestamp":1787314855852,"version":"build-2736575974"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY16H120004"],"award-info":[{"award-number":["LY16H120004"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY17H150003"],"award-info":[{"award-number":["LY17H150003"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY14H020005"],"award-info":[{"award-number":["LY14H020005"]}]},{"name":"Wenzhou Science & Technology Bureau","award":["Y20180168"],"award-info":[{"award-number":["Y20180168"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aim of this study was to investigate the effect of mesenchymal stem cells (MSCs) on the angiogenesis of human umbilical vein endothelial cells (HUVECs). MSCs were subconjunctival injected into rat corneal alkali burn models. Their impacts on the degree of corneal neovascularization (CNV) and corneal opacity were evaluated at 3, 6, 9 and 12 days after injection. An in vitro experiment of MSCs affecting HUVECs angiogenesis was performed and evaluated using the tube formation assay. The results showed that both CNV and corneal opacity were decreased in rats after MSCs injection. In HUVECs, angiogenesis of cells was inhibited by miR-211 overexpression. miR-211 negatively regulated Prox1 expression. Knockdown of miR-211 blocked the decrease of Prox1 expression induced by MSCs and the inhibitory effect of MSCs on the angiogenesis of HUVECs. The critical role of miR-211 in MSCs inhibition of corneal angiogenesis was confirmed in rat experiments. We concluded that MSCs inhibited the angiogenesis of HUVEC through miR-211 mediating the down-regulation of Prox1.<\/jats:p>","DOI":"10.1093\/jb\/mvz038","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T18:00:47Z","timestamp":1557252047000},"page":"107-113","source":"Crossref","is-referenced-by-count":21,"title":["MSCs inhibits the angiogenesis of HUVECs through the miR-211\/Prox1 pathway"],"prefix":"10.1093","volume":"166","author":[{"given":"Jian","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dequan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Traumatology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zipei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,29]]},"reference":[{"key":"2019070309325405900_mvz038-B1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.5483\/BMBRep.2015.48.11.041","article-title":"PEP-1-FK506BP inhibits alkali burn-induced corneal inflammation on the rat model of corneal alkali injury","volume":"48","author":"Kim","year":"2015","journal-title":"BMB Rep."},{"key":"2019070309325405900_mvz038-B2","first-page":"688","article-title":"Fasudil hydrochloride, a potent ROCK inhibitor, inhibits corneal neovascularization after alkali burns in mice","volume":"21","author":"Zeng","year":"2015","journal-title":"Mol. 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