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The results show a stronger shift in redox status to pro-oxidative conditions (observed as an increased reactive oxygen species level, a decrease in catalase activity and lower levels of glutathione peroxidase and vitamin E compared with healthy controls) in the lymphocytes of PsA than PsV patients. It is also favoured by the enhanced level of activators of the Nrf2 transcription factor in lymphocytes of PsV compared with decreased of these proteins level in PsA. Moreover, the differential modifications of proteins by lipid peroxidation products 4-oxononenal (mainly binding proteins) and malondialdehyde (mainly catalytic proteins with redox activity), promoted a pro-apoptotic pathway in lymphocytes of PsV, which was manifested by enhanced expression of pro-apoptotic caspases, particularly caspase 3. Taken together, differences in Nrf2 pathway activation may be responsible for the differential level of redox imbalance in lymphocytes of patients with PsV and PsA. This finding may enable identification of a targeted therapy to modify the metabolic pathways disturbed in psoriasis.<\/jats:p>","DOI":"10.1093\/jb\/mvz096","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T12:10:54Z","timestamp":1573128654000},"page":"323-331","source":"Crossref","is-referenced-by-count":22,"title":["Effect of redox imbalance on protein modifications in lymphocytes of psoriatic patients"],"prefix":"10.1093","volume":"167","author":[{"given":"Piotr","family":"W\u00f3jcik","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"G\u0119gotek","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Wro\u0144ski","sequence":"first","affiliation":[{"name":"Dermatological Specialized Center \u201cDERMAL\u201d NZOZ in Bia\u0142ystok, Nowy \u015awiat 17\/5, 15-453 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Jastrz\u0105b","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"\u017bebrowska","sequence":"first","affiliation":[{"name":"Regional Center for Blood Donation and Blood Treatment, M. 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