{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T14:06:22Z","timestamp":1767276382985},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Stimulant (cocaine, methamphetamine, and amphetamine) abuse compromises the peripheral vasculature through endothelial injury. In combination with the physiologic derangements seen in burn injuries, patients abusing stimulants may have additional impairments in wound healing. A retrospective review from July 1, 2015 to July 1, 2018 was performed at an American Burn Association-verified burn center. Patients with positive urine toxicology results for stimulants (ST(+)), and those without (ST(\u2212)), who sustained burn injuries were identified and matched by age and TBSA. The primary outcome was mortality, and secondary outcomes included total length of stay (LOS), and need-for-surgery (grafting). In total, 130 patients ST(+) and 133 ST(\u2212) patients were identified. There were no significant differences in age (40.9 \u00b1 13.5 vs 39.2 \u00b1 23.7 years, P = 0.46), Inhalation Injury (12.3 vs 9.0%, P = 0.39), or nutritional status (prealbumin: 17.3 \u00b1 6.1 vs 17.1 \u00b1 12.7 mg\/dl, P = 0.66; albumin: 3.5 \u00b1 0.6 vs 3.6 \u00b1 0.7 g\/dl, P = 0.45). There were no differences in mortality (6.1 vs 4.5%, P = 0.55), intensive care unit LOS (9.3 \u00b1 16.5 vs 10.2 \u00b1 20.9 days, P = 0.81), wound infections (15.4 vs 23.9%, P = 0.07), or wound conversion (6.9 vs 3.0%, P = 0.14). ST(+) patients had a significantly longer LOS (15.0 \u00b1 16.9 vs 10.7 \u00b1 17.3 days, P = 0.04), greater tobacco use (56.9 vs 18.0%, P = 0.00001), and greater need for grafting (54.6 vs 33.1%, P = 0.0004). ST(+) patients require more hospital resources\u2014surgical operations and hospital days\u2014than ST(\u2212) patients. The increased need for surgical intervention may partially explain the increase in hospital days, in addition to the observation that ST(+) patients had more complex disposition issues than ST(\u2212) patients.<\/jats:p>","DOI":"10.1093\/jbcr\/iraa087","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T19:23:20Z","timestamp":1592249000000},"page":"921-925","source":"Crossref","is-referenced-by-count":4,"title":["Stimulant Abuse in Burn Patients Is Associated With an Increased Use of Hospital Resources"],"prefix":"10.1093","volume":"41","author":[{"given":"Ian F","family":"Hulsebos","sequence":"first","affiliation":[{"name":"Division of Plastic Surgery, University of Southern California, Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher H","family":"Pham","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, University of Southern California, Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary J","family":"Collier","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, University of Southern California, Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian Q","family":"Vrouwe","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, University of Southern California, Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Surgery, Harbor+UCLA Medical Center, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haig A","family":"Yenikomshian","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, University of Southern California, Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren L","family":"Garner","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, University of Southern California, Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Gillenwater","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, University of Southern California, Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"2020092312350096800_CIT0001","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.amjsurg.2018.01.028","article-title":"Patient and social characteristics contributing to disparities in outcomes after burn injury: application of database research to minority health in the burn population","volume":"216","author":"Chen","year":"2018","journal-title":"Am J Surg"},{"key":"2020092312350096800_CIT0002","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1016\/j.burns.2016.06.001","article-title":"Acute mental disorders and short and long term morbidity in patients with third degree flame burn: a population-based outcome study of 96,451 patients from the Nationwide Inpatient Sample (NIS) database (2001\u20132011)","volume":"42","author":"Mahendraraj","year":"2016","journal-title":"Burns"},{"key":"2020092312350096800_CIT0003","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1097\/BCR.0000000000000407","article-title":"The effect of illicit drug use on outcomes following burn injury","volume":"38","author":"Hodgman","year":"2017","journal-title":"J Burn Care Res"},{"key":"2020092312350096800_CIT0004","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1124\/mol.113.090118","article-title":"Adrenaline rush: the role of adrenergic receptors in stimulant-induced behaviors","volume":"85","author":"Schmidt","year":"2014","journal-title":"Mol Pharmacol"},{"key":"2020092312350096800_CIT0005","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neulet.2018.06.005","article-title":"A recreational dose of methylphenidate, but not methamphetamine, decreases anxiety-like behavior in female rats","volume":"682","author":"Boyette-Davis","year":"2018","journal-title":"Neurosci Lett"},{"key":"2020092312350096800_CIT0006","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.atherosclerosis.2017.03.019","article-title":"Vascular disease in cocaine addiction","volume":"262","author":"Bachi","year":"2017","journal-title":"Atherosclerosis"},{"key":"2020092312350096800_CIT0007","doi-asserted-by":"crossref","first-page":"e176","DOI":"10.2459\/JCM.0000000000000083","article-title":"Lower limb ischemia due to long-term abuse of cocaine","volume":"17","author":"Denegri","year":"2016","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"2020092312350096800_CIT0008","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.phrs.2008.06.007","article-title":"The immune system and cardiac repair","volume":"58","author":"Frangogiannis","year":"2008","journal-title":"Pharmacol Res"},{"key":"2020092312350096800_CIT0009","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.redox.2017.04.008","article-title":"Cigarette smoke extract counteracts atheroprotective effects of high laminar flow on endothelial function","volume":"12","author":"Giebe","year":"2017","journal-title":"Redox Biol"},{"key":"2020092312350096800_CIT0010","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/01.BCR.0000138298.30449.AA","article-title":"Methamphetamine-associated burn injuries: a retrospective analysis","volume":"25","author":"Danks","year":"2004","journal-title":"J Burn Care Rehabil"},{"key":"2020092312350096800_CIT0011","first-page":"228","article-title":"Methamphetamine laboratory explosions: a new and emerging burn injury","volume":"26","author":"Santos","year":"2005","journal-title":"J Burn Care Rehabil"},{"key":"2020092312350096800_CIT0012","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/BCR.0b013e31816677ee","article-title":"Slightly hypertonic saline and dextran-40 in resuscitation of methamphetamine burn patients","volume":"29","author":"Juern","year":"2008","journal-title":"J Burn Care Res"},{"key":"2020092312350096800_CIT0013","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.burns.2012.03.003","article-title":"Resurgence of methamphetamine related burns and injuries: a follow-up study","volume":"39","author":"Davidson","year":"2013","journal-title":"Burns"},{"key":"2020092312350096800_CIT0014","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.burns.2007.08.015","article-title":"Acute anhydrous ammonia injury from accidents during illicit methamphetamine production","volume":"34","author":"Bloom","year":"2008","journal-title":"Burns"},{"key":"2020092312350096800_CIT0015","author":"United States Drug Enforcement Administration Division of Data Statistics and Information, Department of Justice","year":"2018"},{"key":"2020092312350096800_CIT0016","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/01.BCR.0000085855.14964.01","article-title":"The methamphetamine burn patient","volume":"24","author":"Warner","year":"2003","journal-title":"J Burn Care Rehabil"},{"key":"2020092312350096800_CIT0017","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13722-018-0112-6","article-title":"Evaluation of the effect of methamphetamine on traumatic injury complications and outcomes","volume":"13","author":"Neeki","year":"2018","journal-title":"Addict Sci Clin Pract"},{"key":"2020092312350096800_CIT0018","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/BCR.0b013e31817db832","article-title":"Methamphetamine-related burns in the cornbelt","volume":"29","author":"Burke","year":"2008","journal-title":"J Burn Care Res"},{"key":"2020092312350096800_CIT0019","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1097\/TA.0b013e3181a0e589","article-title":"Methamphetamine production is hazardous to your health","volume":"66","author":"Blostein","year":"2009","journal-title":"J Trauma"},{"key":"2020092312350096800_CIT0020","doi-asserted-by":"crossref","first-page":"22S","DOI":"10.1016\/0002-9343(92)90623-J","article-title":"Smoking and wound healing","volume":"93","author":"Silverstein","year":"1992","journal-title":"Am J Med"},{"key":"2020092312350096800_CIT0021","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1172\/JCI32169","article-title":"Cellular and molecular basis of wound healing in diabetes","volume":"117","author":"Brem","year":"2007","journal-title":"J Clin Invest"},{"key":"2020092312350096800_CIT0022","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/01.BCR.0000226056.81279.C9","article-title":"Characteristics of burn patients injured in methamphetamine laboratory explosions","volume":"27","author":"Spann","year":"2006","journal-title":"J Burn Care Res"}],"container-title":["Journal of Burn Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/iraa087\/33480791\/iraa087.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jbcr\/article-pdf\/41\/5\/921\/33784480\/iraa087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jbcr\/article-pdf\/41\/5\/921\/33784480\/iraa087.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T16:45:15Z","timestamp":1600879515000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbcr\/article\/41\/5\/921\/5857753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,15]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,6,15]]},"published-print":{"date-parts":[[2020,9,23]]}},"URL":"https:\/\/doi.org\/10.1093\/jbcr\/iraa087","relation":{},"ISSN":["1559-047X","1559-0488"],"issn-type":[{"value":"1559-047X","type":"print"},{"value":"1559-0488","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,9]]},"published":{"date-parts":[[2020,6,15]]}}}