{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:22:29Z","timestamp":1790302949609,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T00:00:00Z","timestamp":1621123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Hitchcock Surgical Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Frostbite is a high morbidity, high-cost injury that can lead to digit or limb necrosis requiring amputation. Our primary aim is to describe the rate of readmission following frostbite injury. Our secondary aims are to describe the overall burden of care, cost, and characteristics of repeat hospitalizations of frostbite-injured people. Hospitalizations following frostbite injury (index and readmissions) were identified in the 2016 and 2017 Nationwide Readmission Database. Multivariable logistic regression was clustered by hospital and additionally adjusted for severe frostbite injury, gender, year, payor group, severity, and comorbidity index. Population estimates were calculated and adjusted for by using survey weight, sampling clusters, and stratum. In the 2-year cohort, 1065 index hospitalizations resulted in 1907 total hospitalizations following frostbite injury. Most patients were male (80.3%), lived in metropolitan\/urban areas (82.3%), and nearly half were insured with Medicaid (46.4%). Of the 842 readmissions, 53.7% were associated with complications typically associated with frostbite injury. Overall, 29% of frostbite injuries resulted in at least one amputation. The average total cost and total length of stay of readmissions were $236,872 and 34.7 days. Drug or alcohol abuse, homelessness, Medicaid insurance, and discharge against medical advice (AMA) were independent predictors of unplanned readmission. Factors associated with multiple readmissions include discharge AMA and Medicare insurance, but not drug or alcohol abuse or homelessness. The population-based estimated unplanned readmission rate following frostbite injury was 35.4% (95% confidence interval 32.2%\u201338.6%). This is the first study examining readmissions following frostbite injury on a national level. Drug or alcohol abuse, homelessness, Medicaid insurance, and discharge AMA were independent predictors of unplanned readmission, while only AMA discharge and Medicare insurance were associated with multiple readmissions. Supportive resources (community and hospital-based) may reduce unplanned readmissions of frostbite-injured patients with those additional risk factors.<\/jats:p>","DOI":"10.1093\/jbcr\/irab076","type":"journal-article","created":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T14:18:56Z","timestamp":1621174736000},"page":"857-864","source":"Crossref","is-referenced-by-count":26,"title":["High Cost and Resource Utilization of Frostbite Readmissions in the United States"],"prefix":"10.1093","volume":"42","author":[{"given":"Frederick W","family":"Endorf","sequence":"first","affiliation":[{"name":"Department of Surgery, Hennepin Healthcare, Minneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M","family":"Nygaard","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hennepin Healthcare, Minneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,16]]},"reference":[{"key":"2021093015534563900_CIT0001","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.hcl.2009.06.004","article-title":"Cold injury","volume":"25","author":"Mohr","year":"2009","journal-title":"Hand Clin"},{"key":"2021093015534563900_CIT0002","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1580\/1080-6032(2001)012[0248:RSOCOS]2.0.CO;2","article-title":"Retrospective study of 70 cases of severe frostbite lesions: a proposed new classification scheme","volume":"12","author":"Cauchy","year":"2001","journal-title":"Wilderness Environ Med"},{"key":"2021093015534563900_CIT0003","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/jbcr\/irz062","article-title":"Urban frostbite: strategies for limb salvage","volume":"40","author":"Shenaq","year":"2019","journal-title":"J Burn Care Res"},{"key":"2021093015534563900_CIT0004","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1093\/jbcr\/iraa028","article-title":"Thrombolytic use in management of frostbite injuries: eight year retrospective review at a single institution","volume":"41","author":"Heard","year":"2020","journal-title":"J Burn Care Res"},{"key":"2021093015534563900_CIT0005","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1097\/BCR.0000000000000245","article-title":"Use of intra-arterial thrombolytic therapy for acute treatment of frostbite in 62 patients with review of thrombolytic therapy in frostbite","volume":"37","author":"Gonzaga","year":"2016","journal-title":"J Burn Care Res"},{"key":"2021093015534563900_CIT0006","doi-asserted-by":"crossref","first-page":"e317","DOI":"10.1097\/BCR.0000000000000277","article-title":"The Hennepin score: quantification of frostbite management efficacy","volume":"37","author":"Nygaard","year":"2016","journal-title":"J Burn Care Res"},{"key":"2021093015534563900_CIT0007","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/BCR.0000000000000426","article-title":"Time matters in severe frostbite: assessment of limb\/digit salvage on the individual patient level","volume":"38","author":"Nygaard","year":"2017","journal-title":"J Burn Care Res"},{"key":"2021093015534563900_CIT0008","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1001\/archsurg.142.6.546","article-title":"Reduction of the incidence of amputation in frostbite injury with thrombolytic therapy","volume":"142","author":"Bruen","year":"2007","journal-title":"Arch Surg"},{"key":"2021093015534563900_CIT0009","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/jbcr\/irz118","article-title":"Using intra-arterial tPA for severe frostbite cases. 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