{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:15:20Z","timestamp":1781360120054,"version":"3.54.1"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The complex management of severe burn victims requires an integrative collaboration of multidisciplinary specialists in order to ensure quality and excellence in healthcare. This multidisciplinary care has quickly led to the integration of cell therapies in clinical care of burn patients. Specific advances in cellular therapy together with medical care have allowed for rapid treatment, shorter residence in hospitals and intensive care units, shorter durations of mechanical ventilation, lower complications and surgery interventions, and decreasing mortality rates. However, naturally fluctuating patient admission rates increase pressure toward optimized resource utilization. Besides, European translational developments of cellular therapies currently face potentially jeopardizing challenges on the policy front. The aim of the present work is to provide key considerations in burn care with focus on architectural and organizational aspects of burn centers, management of cellular therapy products, and guidelines in evolving restrictive regulations relative to standardized cell therapies. Thus, based on our experience, we present herein integrated management of risks and costs for preserving and optimizing clinical care and cellular therapies for patients in dire need.<\/jats:p>","DOI":"10.1093\/jbcr\/irab080","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T18:40:28Z","timestamp":1620672028000},"page":"911-924","source":"Crossref","is-referenced-by-count":22,"title":["Burn Center Organization and Cellular Therapy Integration: Managing Risks and Costs"],"prefix":"10.1093","volume":"42","author":[{"given":"Mich\u00e8le","family":"Chemali","sequence":"first","affiliation":[{"name":"Department of Musculoskeletal Medicine, Plastic, Reconstructive and Hand Surgery Service, Lausanne University Hospital, University of Lausanne, Switzerland"},{"name":"Department of Interdisciplinary Centers, Lausanne Burn Center, Lausanne University Hospital, University of Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Laurent","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Medicine, Plastic, Reconstructive and Hand Surgery Service, Lausanne University Hospital, University of Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Scaletta","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Medicine, Plastic, Reconstructive and Hand Surgery Service, Lausanne University Hospital, University of Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Waselle","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Centers, Cell Production Center, Service of Pharmacy, Lausanne University Hospital, University of Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne-Pascale","family":"Simon","sequence":"additional","affiliation":[{"name":"DIrectorate Department, Unit of Legal Affairs, Lausanne University Hospital, University of Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murielle","family":"Michetti","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Medicine, Plastic, Reconstructive and Hand Surgery Service, Lausanne University Hospital, University of Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Brunet","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Centers, Cell Production Center, Service of Pharmacy, Lausanne University Hospital, University of Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Flahaut","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Medicine, Plastic, Reconstructive and Hand Surgery Service, Lausanne University Hospital, University of Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Hirt-Burri","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Medicine, Plastic, Reconstructive and Hand Surgery Service, Lausanne University Hospital, University of Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim","family":"Raffoul","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Medicine, Plastic, Reconstructive and Hand Surgery Service, Lausanne University Hospital, University of Lausanne, Switzerland"},{"name":"Department of Interdisciplinary Centers, Lausanne Burn Center, Lausanne University Hospital, University of Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee Ann","family":"Applegate","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Medicine, Plastic, Reconstructive and Hand Surgery Service, Lausanne University Hospital, University of Lausanne, Switzerland"},{"name":"Department of Interdisciplinary Centers, Lausanne Burn Center, Lausanne University Hospital, University of Lausanne, Switzerland"},{"name":"Oxford Suzhou Center for Advanced Research, Science and Technology Co. Ltd., Oxford University, Suzhou, PR China"},{"name":"Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony S","family":"de Buys Roessingh","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Centers, Lausanne Burn Center, Lausanne University Hospital, University of Lausanne, Switzerland"},{"name":"Women-Mother-Child Department, Children and Adolescent Surgery Service, Lausanne University Hospital, University of Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6054-0573","authenticated-orcid":false,"given":"Philippe","family":"Abdel-Sayed","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Medicine, Plastic, Reconstructive and Hand Surgery Service, Lausanne University Hospital, University of Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,10]]},"reference":[{"key":"2021093015535088000_CIT0001","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1089\/wound.2019.1037","article-title":"Evolution of biological bandages as first cover for burn patients","volume":"8","author":"Abdel-Sayed","year":"2019","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"2021093015535088000_CIT0002","first-page":"w20079","article-title":"Cell therapies for skin regeneration: an overview of 40 years of experience in burn units","volume":"149","author":"Abdel-Sayed","year":"2019","journal-title":"Swiss Med Wkly"},{"key":"2021093015535088000_CIT0003","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000178865","article-title":"Whole-cell bioprocessing of human fetal cells for tissue engineering of skin","volume":"22","author":"Applegate","year":"2009","journal-title":"Skin Pharmacol Physiol"},{"key":"2021093015535088000_CIT0004","first-page":"111","article-title":"Burn patient care lost in good manufacturing practices?","volume":"29","author":"Dimitropoulos","year":"2016","journal-title":"Ann Burns Fire Disasters"},{"key":"2021093015535088000_CIT0005","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1755-1536-6-8","article-title":"Autologous keratinocyte suspension in platelet concentrate accelerates and enhances wound healing\u2014a prospective randomized clinical trial on skin graft donor sites: platelet concentrate and keratinocytes on donor sites","volume":"6","author":"Guerid","year":"2013","journal-title":"Fibrogenesis Tissue Repair"},{"key":"2021093015535088000_CIT0006","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0140-6736(05)67107-3","article-title":"Tissue engineered fetal skin constructs for paediatric burns","volume":"366","author":"Hohlfeld","year":"2005","journal-title":"Lancet"},{"key":"2021093015535088000_CIT0007","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3727\/000000007783465127","article-title":"Consistency and safety of cell banks for research and clinical use: preliminary analysis of fetal skin banks","volume":"16","author":"Quintin","year":"2007","journal-title":"Cell Transplant"},{"key":"2021093015535088000_CIT0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2325-9620.1000122","article-title":"A decade after foetal skin progenitor cell therapy in pediatric burn treatment","volume":"4","author":"de Buys Roessingh","year":"2015","journal-title":"J Regen Med"},{"key":"2021093015535088000_CIT0009","doi-asserted-by":"crossref","first-page":"963689720973642","DOI":"10.1177\/0963689720973642","article-title":"Surgical management evolution between 2 massive burn cases at 17-year interval: contribution of cell therapies in improving the surgical care","volume":"29","author":"Monnier","year":"2020","journal-title":"Cell Transplant"},{"key":"2021093015535088000_CIT0010","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.burns.2008.02.010","article-title":"Mortality and causes of death in a burn centre","volume":"34","author":"Bloemsma","year":"2008","journal-title":"Burns"},{"key":"2021093015535088000_CIT0011","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.burns.2011.06.005","article-title":"Epidemiology of burns throughout the world. 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