{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:30:09Z","timestamp":1768876209738,"version":"3.49.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Stevens\u2013Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute, life-threatening diseases that cause sloughing of the skin and mucous membranes. Despite improved survival rates, few studies focus on long-term outcomes. We conducted a single-center review of all patients with SJS\/TEN admitted from January 2008 to 2014. SJS\/TEN survivors were invited to participate in the validated Veterans RAND 12-Item Health Survey (VR-12) to assess health-related quality of life using a mental health composite score and physical health component score (PCS). The sample was compared to U.S. norms using one-sample two-tailed t tests. A second questionnaire addressed potential long-term medical complications related to SJS\/TEN. Of 81 treated subjects, 24 (30%) long-term survivors responded. Participants identified cutaneous sequelae most frequently (79%), followed by nail problems (70%), oral (62%), and ocular (58%) sequalae. Thirty-eight percent rated their quality of life to be \u201cunchanged\u201d to \u201cmuch better\u201d since their episode of SJS\/TEN. The average PCS was lower than U.S. population norms (mean: 36 vs 50, P = .006), indicating persistent physical sequelae from SJS\/TEN. These results suggest that SJS\/TEN survivors continue to suffer from long-term complications that impair their quality of life and warrant ongoing follow-up by a multidisciplinary care team.<\/jats:p>","DOI":"10.1093\/jbcr\/irab109","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T12:19:06Z","timestamp":1623241146000},"page":"1227-1231","source":"Crossref","is-referenced-by-count":5,"title":["Physical and Psychological Recovery Following Toxic Epidermal Necrolysis: A Patient Survey"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8615-7786","authenticated-orcid":false,"given":"Katherine L","family":"DeNiro","sequence":"first","affiliation":[{"name":"Division of Dermatology, University of Washington, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shari","family":"Honari","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Washington Medicine UW Medicine Regional Burn Center, Seattle, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan S","family":"Hippe","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Washington, Seattle, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Washington Medicine UW Medicine Regional Burn Center, Seattle, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam N","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Washington Medicine UW Medicine Regional Burn Center, Seattle, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Caceres","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Washington Medicine UW Medicine Regional Burn Center, Seattle, USA"},{"name":"Huntsville Hospital, Alabama, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel P","family":"Mandell","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Washington Medicine UW Medicine Regional Burn Center, Seattle, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phi Q","family":"Duong","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Washington Medicine UW Medicine Regional Burn Center, Seattle, USA"},{"name":"Seattle Children\u2019s Research Institute, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara A","family":"McMullen","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, University of Washington, Seattle, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole S","family":"Gibran","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Washington Medicine UW Medicine Regional Burn Center, Seattle, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"2021120105070786100_CIT0001","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1001\/archderm.1993.01680220104023","article-title":"Clinical classification of cases of toxic epidermal necrolysis, Stevens\u2013Johnson syndrome, and erythema multiforme","volume":"129","author":"Bastuji-Garin","year":"1993","journal-title":"Arch Dermatol"},{"key":"2021120105070786100_CIT0002","first-page":"247","article-title":"Trends in mortality rates for Stevens\u2013Johnson syndrome and toxic epidermal necrolysis: experience of a single centre in France between 1997 and 2017","volume":"182","author":"Bettuzzi","year":"2020","journal-title":"Br J Dermatol"},{"key":"2021120105070786100_CIT0003","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/00006534-199809020-00014","article-title":"Toxic epidermal necrolysis syndrome: mortality rate reduced with early referral to regional burn center","volume":"102","author":"McGee","year":"1998","journal-title":"Plast Reconstr Surg"},{"key":"2021120105070786100_CIT0004","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1001\/jama.1987.03390160057026","article-title":"Toxic epidermal necrolysis. 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