{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:21:19Z","timestamp":1791951679137,"version":"4.3.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Diabetes mellitus is an increasingly prevalent chronic disease that leads to long-term health consequences. Some long-term clinical sequelae of diabetes include coronary artery disease, peripheral vascular disease, peripheral neuropathy, and impaired wound healing. These can increase hospital stay and complications such as wound infections and amputations among patients with lower extremity burns. A retrospective analysis was performed of all isolated lower extremity burns from a single tertiary burn care center from 2006 to 2017. Patients were stratified by diabetic status and the incidence of lower extremity amputations was the primary outcome. Multivariable regression was used to model the association between diabetes and amputations, adjusting for patient and injury characteristics. A total of 198 patients were identified as meeting inclusion criteria, 160 were nondiabetic and 38 were diabetic. Age was significantly different between nondiabetic and diabetic patients; mean age was 46 \u00b1 18 vs 62 \u00b1 17 years (P &amp;lt; .0001). Length of stay was also significantly different, median length of stay was 11 (interquartile range 7\u201315) vs 18 (interquartile range 12\u201324; P &amp;lt; .001), with diabetic patients staying longer. There was a significantly greater proportion of diabetic patients that had an amputation (control 4% vs diabetic 29%; P &amp;lt; .0001). After adjustment for patient and injury characteristics, there was a significant association between diabetes and amputation (P = .002). Among patients with isolated lower extremity burns, those with a preexisting condition of diabetes had a longer hospitalization and increased amputations, despite similar size of burn. Diabetes is an important risk factor to acknowledge in patients with these injuries to optimize care.<\/jats:p>","DOI":"10.1093\/jbcr\/irab150","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T19:13:38Z","timestamp":1627672418000},"page":"93-97","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of Clinical Outcomes of Lower Extremity Burns in Diabetic and Nondiabetic Patients: A Retrospective Analysis"],"prefix":"10.1093","volume":"43","author":[{"given":"Sydney","family":"Rotman","sequence":"first","affiliation":[{"name":"Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada"},{"name":"Sunnybrook Research Institute, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Lapaine","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Faculty of Medicine, University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Rehou","sequence":"additional","affiliation":[{"name":"Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada"},{"name":"Sunnybrook Research Institute, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0870-1664","authenticated-orcid":false,"given":"Marc G","family":"Jeschke","sequence":"additional","affiliation":[{"name":"Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada"},{"name":"Sunnybrook Research Institute, Toronto, Ontario, Canada"},{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Faculty of Medicine, University of Toronto, Ontario, Canada"},{"name":"Department of Immunology, Faculty of Medicine, University of Toronto, Ontario, Canada"},{"name":"Institute of Medical Science, Faculty of Medicine, University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahriar","family":"Shahrokhi","sequence":"additional","affiliation":[{"name":"Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada"},{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Faculty of Medicine, University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"2022010702421483300_CIT0001","volume-title":"Diabetes Canada. 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Part II\u2014outcomes from burn injuries and future directions","volume":"5","author":"Goutos","year":"2015","journal-title":"Int J Burns Trauma"},{"key":"2022010702421483300_CIT0011","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.burns.2016.06.023","article-title":"Systematic review of complications and outcomes of diabetic patients with burn trauma","volume":"42","author":"Sayampanathan","year":"2016","journal-title":"Burns"},{"key":"2022010702421483300_CIT0012","first-page":"181","article-title":"Diabetes and foot burns","volume":"31","author":"Momeni","year":"2018","journal-title":"Ann Burns Fire Disasters"},{"key":"2022010702421483300_CIT0013","doi-asserted-by":"crossref","first-page":"352","DOI":"10.2337\/cd18-0066","article-title":"Neuropathy may be an independent risk factor for amputation after lower-extremity burn in adults with diabetes","volume":"37","author":"Sen","year":"2019","journal-title":"Clin Diabetes"},{"key":"2022010702421483300_CIT0014","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.burns.2012.06.006","article-title":"Clinical outcomes of isolated lower extremity or foot burns in diabetic versus non-diabetic patients: a 10-year retrospective analysis","volume":"39","author":"Kimball","year":"2013","journal-title":"Burns"},{"key":"2022010702421483300_CIT0015","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1128\/CMR.19.2.403-434.2006","article-title":"Burn wound infections","volume":"19","author":"Church","year":"2006","journal-title":"Clin Microbiol Rev"},{"key":"2022010702421483300_CIT0016","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/jbcr\/irz182","article-title":"Lower extremity burns, complications and outcome","volume":"41","author":"Momeni","year":"2019","journal-title":"J Burn Care Res"},{"key":"2022010702421483300_CIT0017","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13054-019-2328-6","article-title":"The effect of diabetes on burn patients: a retrospective cohort study","volume":"23","author":"Dolp","year":"2019","journal-title":"Crit Care"},{"key":"2022010702421483300_CIT0018","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1016\/j.burns.2018.07.004","article-title":"Contributors to the length-of-stay trajectory in burn-injured patients","volume":"44","author":"Dolp","year":"2018","journal-title":"Burns"},{"key":"2022010702421483300_CIT0019","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1097\/00005373-198808000-00023","article-title":"The medical and economic impact of severely injured lower extremities","volume":"28","author":"Bondurant","year":"1988","journal-title":"J Trauma"},{"key":"2022010702421483300_CIT0020","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1097\/CCM.0000000000001605","article-title":"Burned adults develop profound glucose intolerance","volume":"44","author":"Rehou","year":"2016","journal-title":"Crit Care Med"},{"key":"2022010702421483300_CIT0021","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00004630-200205000-00004","article-title":"Diabetes and burns: retrospective cohort study","volume":"23","author":"McCampbell","year":"2002","journal-title":"J Burn Care Rehabil"}],"container-title":["Journal of Burn Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/irab150\/39905396\/irab150.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/article-pdf\/43\/1\/93\/42077397\/irab150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/article-pdf\/43\/1\/93\/42077397\/irab150.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T02:42:34Z","timestamp":1641523354000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbcr\/article\/43\/1\/93\/6330951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,30]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,7,30]]},"published-print":{"date-parts":[[2022,1,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jbcr\/irab150","relation":{},"ISSN":["1559-047X","1559-0488"],"issn-type":[{"value":"1559-047X","type":"print"},{"value":"1559-0488","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,1]]},"published":{"date-parts":[[2021,7,30]]}}}