{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:09:24Z","timestamp":1791234564337,"version":"4.1.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG018859"],"award-info":[{"award-number":["R01 AG018859"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 GM131831"],"award-info":[{"award-number":["R35 GM131831"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R24 AA019661"],"award-info":[{"award-number":["R24 AA019661"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08 GM134185"],"award-info":[{"award-number":["K08 GM134185"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Veterans Affairs Merit Award","award":["1 I01 BX004335"],"award-info":[{"award-number":["1 I01 BX004335"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Clinical studies have demonstrated that age 50 years or older is an independent risk factor associated with poor prognosis after burn injury, the second leading cause of traumatic injuries in the aged population. While mechanisms driving age-dependent postburn mortality are perplexing, changes in the intestinal microbiome, may contribute to the heightened, dysregulated systemic response seen in aging burn patients. The fecal microbiome from 22 patients admitted to a verified burn center from July 2018 to February 2019 was stratified based on the age of 50 years and total burn surface area (TBSA) size of \u226510%. Significant differences (P = .014) in overall microbiota community composition (ie, beta diversity) were measured across the four patient groups: young &amp;lt;10% TBSA, young \u226510% TBSA, older &amp;lt;10% TBSA, and older \u226510% TBSA. Differences in beta diversity were driven by %TBSA (P = .013) and trended with age (P = .087). Alpha diversity components, richness, evenness, and Shannon diversity were measured. We observed significant differences in bacterial species evenness (P = .0023) and Shannon diversity (P = .0033) between the groups. There were significant correlations between individual bacterial species and levels of short-chain fatty acids. Specifically, levels of fecal butyrate correlated with the presence of Enterobacteriaceae, an opportunistic gut pathogen, when elevated in burn patients lead to worsen outcomes. Overall, our findings reveal that age-specific changes in the fecal microbiome following burn injuries may contribute to immune system dysregulation in patients with varying TBSA burns and potentially lead to worsened clinical outcomes with heightened morbidity and mortality.<\/jats:p>","DOI":"10.1093\/jbcr\/irac001","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T20:23:37Z","timestamp":1642019017000},"page":"1145-1153","source":"Crossref","is-referenced-by-count":16,"title":["Age and Injury Size Influence the Magnitude of Fecal Dysbiosis in Adult Burn Patients"],"prefix":"10.1093","volume":"43","author":[{"given":"Kiran","family":"Dyamenahalli","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Colorado Anschutz Medical Campus , Aurora , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Choy","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Colorado Anschutz Medical Campus , Aurora , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel N","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Colorado Anschutz Medical Campus , Aurora , USA"},{"name":"Gastrointestinal and Liver and Innate Immunity Program, University of Colorado Anschutz Medical Campus , Aurora , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Najarro","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Colorado Anschutz Medical Campus , Aurora , USA"},{"name":"Rocky Mountain Regional VA Medical Center, VA Eastern Colorado Health Care System Research Service , Aurora , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin","family":"Boe","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Colorado Anschutz Medical Campus , Aurora , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L","family":"Colborn","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Colorado Anschutz Medical Campus , Aurora , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Pablo","family":"Idrovo","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Colorado Anschutz Medical Campus , Aurora , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne L","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Colorado Anschutz Medical Campus , Aurora , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arek J","family":"Wiktor","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Colorado Anschutz Medical Campus , Aurora , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Afshar","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health , Madison , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen L","family":"Burnham","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus , Aurora , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel H","family":"McMahan","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Colorado Anschutz Medical Campus , Aurora , USA"},{"name":"Rocky Mountain Regional VA Medical Center, VA Eastern Colorado Health Care System Research Service , Aurora , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Colorado Anschutz Medical Campus , Aurora , USA"},{"name":"Rocky Mountain Regional VA Medical Center, VA Eastern Colorado Health Care System Research Service , Aurora , USA"},{"name":"Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus , Aurora , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"2022090113594495300_CIT0001","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1056\/NEJMra1807442","article-title":"Management of burns","volume":"380","author":"Greenhalgh","year":"2019","journal-title":"N Engl J Med"},{"key":"2022090113594495300_CIT0002","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.burns.2017.09.018","article-title":"Clinical outcomes after burns in elderly patients over 70 years: a 17-year retrospective 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