{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:11:36Z","timestamp":1787656296684,"version":"build-2736575974"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the present study was to evaluate effects of curcumin-polyethylene glycol loaded on chitosan-gelatin nanoparticles (C-PEG-CGNPs) on burn wound healing in rat as a model study. Sixty healthy male White Wistar rats were randomized into four experimental groups of 15 animals each: Control group (Control) was treated with normal saline. Carrier group was treated with CGNPs-based ointment (0.05 mg\/ml). Silver sulfadiazine group was treated with silver sulfadiazine 1% ointment. Treatment group was treated with C-PEG-CGNPs (0.05 mg\/ml). Wound size was measured on 7, 14, and 21 days after surgery. The expression of p53, Bcl-2, caspase-3 were evaluated using reverse transcription-polymerase chain reaction and immunohistochemical staining. Reduction in wound area indicated that there was significant difference between Treatment group and other groups (P &amp;lt; .05). Quantitative histological and morphometric studies, and mean rank of the qualitative studies demonstrated that there was a significant difference between Treatment group and other groups (P &amp;lt; .05). Observations demonstrated C-PEG-CGNPs significantly shortened the inflammatory phase and accelerated the cellular proliferation. Accordingly, the animals in Treatment group revealed significantly (P &amp;lt; .05) higher fibroblast distribution\/one mm2 of wound area and rapid reepithelialization. The mRNA levels of Bcl-2, p53, and caspase-3 were remarkably (P &amp;lt; .05) higher in Treatment group compared to control animals. The immunohistochemical analyses confirmed the reverse transcription-polymerase chain reaction findings. C-PEG-CGNPs offered potential advantages in burn wound healing acceleration and improvement.<\/jats:p>","DOI":"10.1093\/jbcr\/irac048","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T15:28:55Z","timestamp":1649950135000},"page":"1399-1409","source":"Crossref","is-referenced-by-count":22,"title":["Curcumin-Polyethylene Glycol Loaded on Chitosan-Gelatin Nanoparticles Enhances Burn Wound Healing in Rat"],"prefix":"10.1093","volume":"43","author":[{"given":"Kimia","family":"Ravanfar","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University , Urmia , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Amniattalab","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University , Urmia , 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