{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:14:51Z","timestamp":1740158091740,"version":"3.37.3"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T00:00:00Z","timestamp":1667088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pemphigus vulgaris is a potentially fatal disease within the epidermis with rare noncutaneous manifestations. Heterotopic ossification has not been previously described as one of the inherent complications of this skin pathology. A 44-year-old man presented with severe pemphigus vulgaris involving 80 to 90% of his body surface area. He had an extended time to wound closure of 5 months, as well as two additional months bed bound due to related infectious and respiratory complications. He progressively developed a worsening range of motion at his bilateral elbows. X-ray demonstrated bilateral anterior elbow heterotopic ossification. Passive and active range of motion exercises were initiated early in the course of his treatment and only yielded a small positive effect. Thus, screening for heterotopic ossification may be warranted when a significant joint range of motion is lost in cases of autoimmune cutaneous disease, and even more in the presence of severe open wounds with delayed wound closure.<\/jats:p>","DOI":"10.1093\/jbcr\/irac162","type":"journal-article","created":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T16:08:23Z","timestamp":1667146103000},"page":"214-217","source":"Crossref","is-referenced-by-count":0,"title":["Anterior Elbow Heterotopic Ossification in Patient With Pemphigus Vulgaris: An Unheard Complication of a Rare Condition"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8908-1713","authenticated-orcid":false,"given":"Stephanie","family":"Jean","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Universit\u00e9 de Montr\u00e9al, Institut de r\u00e9adaptation Gingras-Lindsay-de-Montr\u00e9al , Montreal, QC , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Godleski","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, University of Toronto, Sunnybrook Health Sciences Centre , Toronto, ON , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,30]]},"reference":[{"key":"2023010803181682900_CIT0001","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1468-3083.2011.04363.x","article-title":"Alopecia as a rare but distinct manifestation of pemphigus vulgaris","volume":"27","author":"Veraitch","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010803181682900_CIT0002","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/ced.12634","article-title":"Pemphigus and associated comorbidities: a cross-sectional study","volume":"40","author":"Heelan","year":"2015","journal-title":"Clin Exp Dermatol"},{"key":"2023010803181682900_CIT0003","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1159\/000069955","article-title":"Nail destruction in pemphigus vulgaris","volume":"206","author":"Kolivras","year":"2003","journal-title":"Dermatology"},{"key":"2023010803181682900_CIT0004","first-page":"879","article-title":"Osteoporosis in patients with Pemphigus Vulgaris before steroid therapy","volume":"52","author":"Ghodsi","year":"2014","journal-title":"Acta Med Iran"},{"key":"2023010803181682900_CIT0005","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4103\/0378-6323.107638","article-title":"The frequency of osteoporosis in patients with pemphigus vulgaris on treatment","volume":"79","author":"U\u00e7mak","year":"2013","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"2023010803181682900_CIT0006","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1001\/archdermatol.2010.257","article-title":"Pemphigus and osteoporosis: a case-control study","volume":"146","author":"Wohl","year":"2010","journal-title":"Arch Dermatol"},{"key":"2023010803181682900_CIT0007","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.jse.2013.07.045","article-title":"Radiotherapy for prevention of heterotopic ossification of the elbow: a systematic review of the literature","volume":"22","author":"Ploumis","year":"2013","journal-title":"J Shoulder Elbow Surg"},{"key":"2023010803181682900_CIT0008","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/jbcr\/irz031","article-title":"A Comparison of contracture severity at acute discharge in patients with and without heterotopic ossification: a burn model system National Database Study","volume":"40","author":"Yelvington","year":"2019","journal-title":"J Burn Care Res"},{"issue":"2","key":"2023010803181682900_CIT0009","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1197\/j.jht.2006.02.009","article-title":"Heterotopic ossification about the elbow: a therapist\u2019s guide to evaluation and management","volume":"19","author":"Casavant","year":"2006","journal-title":"J Hand Ther"},{"key":"2023010803181682900_CIT0010","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1016\/j.burns.2012.10.014","article-title":"Range of motion exercises in the setting of burn-associated heterotopic ossification at the elbow: case series and discussion","volume":"39","author":"Coons","year":"2013","journal-title":"Burns"},{"key":"2023010803181682900_CIT0011","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3233\/NRE-2011-0643","article-title":"A comparison of heterotopic ossification treatment within the traumatic brain and spinal cord injured population: an evidence based systematic review","volume":"28","author":"Aubut","year":"2011","journal-title":"NeuroRehabilitation"},{"key":"2023010803181682900_CIT0012","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.jse.2015.05.044","article-title":"The time point in surgical excision of heterotopic ossification of post-traumatic stiff elbow: recommendation for early excision followed by early exercise","volume":"24","author":"Chen","year":"2015","journal-title":"J Shoulder Elbow Surg"},{"key":"2023010803181682900_CIT0013","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/SLA.0000000000001841","article-title":"Predicting Heterotopic ossification early after burn injuries: a risk scoring system","volume":"266","author":"Schneider","year":"2017","journal-title":"Ann Surg"},{"key":"2023010803181682900_CIT0014","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/BCR.0000000000000123","article-title":"Risk Factors in hospitalized patients with burn injuries for developing Heterotopic ossification--a retrospective analysis","volume":"36","author":"Orchard","year":"2015","journal-title":"J Burn Care Res"},{"key":"2023010803181682900_CIT0015","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/BCR.0B013E318053D378","article-title":"Extended time to wound closure is associated with increased risk of Heterotopic ossification of the elbow","volume":"28","author":"Klein","year":"2007","journal-title":"J Burn Care Res"},{"key":"2023010803181682900_CIT0016","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/BCR.0b013e318217f954","article-title":"Impact of diabetes on burn injury: preliminary results from prospective study","volume":"32","author":"Schwartz","year":"2011","journal-title":"J Burn Care Res"},{"key":"2023010803181682900_CIT0017","doi-asserted-by":"crossref","first-page":"34","DOI":"10.7547\/87507315-92-1-34","article-title":"Cellular senescence and matrix metalloproteinase activity in chronic wounds. Relevance to debridement and new technologies","volume":"92","author":"Mulder","year":"2002","journal-title":"J Am Podiatr Med Assoc"},{"volume-title":"Guide pratique en soins de plaies: pr\u00e9vention et traitement","year":"2007","author":"Huppertz","key":"2023010803181682900_CIT0018"},{"key":"2023010803181682900_CIT0019","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1468-3083.2010.03775.x","article-title":"Management of minor acute cutaneous wounds: importance of wound healing in a moist environment","volume":"25","author":"Korting","year":"2011","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010803181682900_CIT0020","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/01.sap.0000099624.04554.63","article-title":"Multifactorial refractory heterotopic ossification","volume":"52","author":"Gear","year":"2004","journal-title":"Ann Plast Surg"},{"key":"2023010803181682900_CIT0021","doi-asserted-by":"crossref","first-page":"7001350010p1","DOI":"10.5014\/ajot.2016.015487","article-title":"Range of motion requirements for upper-limb activities of daily living","volume":"70","author":"Gates","year":"2016","journal-title":"Am J Occu Ther"},{"key":"2023010803181682900_CIT0022","doi-asserted-by":"crossref","first-page":"e0200710","DOI":"10.1371\/journal.pone.0200710","article-title":"Rating scales for shoulder and elbow range of motion impairment: call for a functional approach","volume":"13","author":"Oosterwijk","year":"2018","journal-title":"PLoS One"},{"key":"2023010803181682900_CIT0023","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/ptj\/78.6.593","article-title":"Movement diagram and \u201cend-feel\u201d reliability when measuring passive lateral rotation of the shoulder in patients with shoulder pathology","volume":"78","author":"Chesworth","year":"1998","journal-title":"Phys Ther"},{"key":"2023010803181682900_CIT0024","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/ptj\/74.8.697","article-title":"An examination of Cyriax\u2019s passive motion tests with patients having osteoarthritis of the knee","volume":"74","author":"Hayes","year":"1994","journal-title":"Phys Ther"},{"key":"2023010803181682900_CIT0025","first-page":"1184","volume-title":"Orthopedic physical assessment","author":"Magee","year":"2013","edition":"6"}],"container-title":["Journal of Burn Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/irac162\/47029778\/irac162.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/irac162\/48514677\/irac162.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/irac162\/48514677\/irac162.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T03:20:41Z","timestamp":1673148041000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbcr\/article\/44\/1\/214\/6780293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,30]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,10,30]]},"published-print":{"date-parts":[[2023,1,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jbcr\/irac162","relation":{},"ISSN":["1559-047X","1559-0488"],"issn-type":[{"type":"print","value":"1559-047X"},{"type":"electronic","value":"1559-0488"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,10,30]]}}}