{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:40:19Z","timestamp":1784893219702,"version":"3.55.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Center for Translation Science Advancement","award":["KL2TR003143"],"award-info":[{"award-number":["KL2TR003143"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although single-institution studies have described the relationship between hypothermia, burn severity, and complications, there are no national estimates on how temperature on admission impacts hospital mortality. This study aims to evaluate the relationship between admission temperature and complications on a national scale to expose opportunities for improved outcomes. The US National Trauma Data Bank (NTDB) was analyzed between 2007 and 2018. Mortality was modeled using multivariable logistic regression including burn severity variables (% total burn surface area (TBSA), inhalation injury, emergency department (ED) temperature), demographics, and facility variables. Temperature was parsed into three categories: hypothermia (&amp;lt;36.0\u00b0C), euthermia (36.0\u201337.9\u00b0C), and hyperthermia (\u226538.0\u00b0C). A total of 116,796 burn encounters were included of which 77.9% were euthermic, 20.6% were hypothermic and 1.45% were hyperthermic on admission. For every 1.0C drop in body temperature from 36.0\u00b0C, mortality increased by 5%. Both hypothermia and hyperthermia were independently associated with increased odds of mortality when controlling for age, gender, inhalation injury, number of comorbidities, and %TBSA burned (p\u2005&amp;lt;\u2005.001). All temperatures below 36.0\u00b0C were significantly associated with increased odds of mortality. Patients with ED temperatures between 32.5 and 33.5\u00b0C had the highest odds of mortality (22.0, 95% CI 15.6\u201331.0, p\u2005&amp;lt;\u2005.001). ED hypothermia and hyperthermia are independently associated with mortality even when controlling for known covariates associated with inpatient death. These findings underscore the importance of early warming interventions both at the prehospital stage and upon ED arrival. ED temperature could become a quality metric in benchmarking burn centers to improve mortality.<\/jats:p>","DOI":"10.1093\/jbcr\/irac168","type":"journal-article","created":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T08:28:09Z","timestamp":1667723289000},"page":"845-851","source":"Crossref","is-referenced-by-count":6,"title":["Temperature Derangement on Admission is Associated With Mortality in Burn Patients\u2014A Nationwide Analysis and Opportunity for Improvement"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0063-8584","authenticated-orcid":false,"given":"Eloise","family":"Stanton","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, University of Southern California , Los Angeles ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9410-6030","authenticated-orcid":false,"given":"Justin","family":"Gillenwater","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, University of Southern California , Los Angeles ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam N","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Washington , Seattle ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford C","family":"Sheckter","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Stanford University , Palo Alto ,","place":["USA"]},{"name":"Northern California Regional Burn Center, Santa Clara Valley Medical Center , Palo Alto,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,6]]},"reference":[{"key":"2025121801115582800_CIT0001","doi-asserted-by":"crossref","first-page":"e277","DOI":"10.1097\/BCR.0000000000000371","article-title":"Perioperative temperature management during burn care","volume":"38","author":"Rizzo","year":"2017","journal-title":"J Burn Care Res"},{"key":"2025121801115582800_CIT0002","first-page":"259","article-title":"Unintended perioperative hypothermia","volume":"11","author":"Hart","year":"2011","journal-title":"Ochsner J"},{"key":"2025121801115582800_CIT0003","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.burns.2017.10.001","article-title":"The impact of operative time and hypothermia in acute burn surgery","volume":"43","author":"Ziolkowski","year":"2017","journal-title":"Burns"},{"key":"2025121801115582800_CIT0004","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.enfi.2019.05.002","article-title":"Analysis of hypothermia through the acute phase in major burns patients: nursing care","volume":"31","author":"Alonso-Fern\u00e1ndez","year":"2020","journal-title":"Enferm Intensiva"},{"key":"2025121801115582800_CIT0005","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1097\/SLA.0000000000003447","article-title":"Trends of burn injury in the United States: 1990 to 2016","volume":"270","author":"Crowe","year":"2019","journal-title":"Ann Surg"},{"key":"2025121801115582800_CIT0006","author":"for Disease Control C, Prevention, Others","year":"2002"},{"key":"2025121801115582800_CIT0007","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1056\/NEJM199209173271207","article-title":"Risk factors for fatal residential fires","volume":"327","author":"Runyan","year":"1992","journal-title":"N Engl J Med"},{"key":"2025121801115582800_CIT0008","author":"Committee NBCR, Others","year":"2001"},{"key":"2025121801115582800_CIT0009","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.ajem.2017.05.001","article-title":"Endovascular rewarming in the emergency department for moderate to severe accidental hypothermia","volume":"35","author":"Klein","year":"2017","journal-title":"Am J Emerg Med"},{"key":"2025121801115582800_CIT0010","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.burns.2018.02.012","article-title":"A quality improvement project incorporating preoperative warming to prevent perioperative hypothermia in major burns","volume":"44","author":"Rogers","year":"2018","journal-title":"Burns"},{"key":"2025121801115582800_CIT0011","author":"National Trauma Data Bank\u00ae (NTDB\u00ae)"},{"key":"2025121801115582800_CIT0012","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1503\/cmaj.110977","article-title":"Missing covariate data in clinical research: when and when not to use the missing-indicator method for analysis","volume":"184","author":"Groenwold","year":"2012","journal-title":"CMAJ"},{"key":"2025121801115582800_CIT0013","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.burns.2015.12.008","article-title":"Threshold age and burn size associated with poor outcomes in the elderly after burn injury","volume":"42","author":"Jeschke","year":"2016","journal-title":"Burns"},{"key":"2025121801115582800_CIT0014","first-page":"82","article-title":"Inhalation injury as a prognostic factor for mortality in burn patients","volume":"24","author":"El-Helbawy","year":"2011","journal-title":"Ann Burns Fire Disasters"},{"key":"2025121801115582800_CIT0015","first-page":"175","article-title":"Influence of gender difference on outcomes of adult burn patients in a developing country","volume":"32","author":"Lam","year":"2019","journal-title":"Ann Burns Fire Disasters"},{"key":"2025121801115582800_CIT0016","author":"Committee on Guidance for Establishing Crisis Standards of Care for Use, Institute of Medicine","year":"2012"},{"key":"2025121801115582800_CIT0017","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.annemergmed.2017.08.038","article-title":"physician medical direction of emergency medical services dispatch programs","volume":"70","year":"2017","journal-title":"Ann Emerg Med"},{"key":"2025121801115582800_CIT0018","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.burns.2018.01.002","article-title":"Effect of primary admission to burn centers on the outcomes of severely burned patients","volume":"44","author":"Ehrl","year":"2018","journal-title":"Burns"},{"key":"2025121801115582800_CIT0019","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/jbcr\/irab092","article-title":"The effect of transfer on outcomes in burns","volume":"42","author":"Bodily","year":"2021","journal-title":"J Burn Care Res"},{"key":"2025121801115582800_CIT0020","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1097\/BCR.0b013e3182a231fb","article-title":"Admission temperature and survival in patients admitted to burn centers","volume":"34","author":"Hostler","year":"2013","journal-title":"J Burn Care Res"},{"key":"2025121801115582800_CIT0021","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.burnso.2020.12.001","article-title":"Hypothermia in acutely presenting burn injuries to a regional burn service: the incidence and impact on outcome","volume":"5","author":"Lukusa","year":"2021","journal-title":"Burns Open"},{"key":"2025121801115582800_CIT0022","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0012-3692(15)51124-0","article-title":"Emergency department hypotension predicts sudden unexpected in-hospital mortality: a prospective cohort study","volume":"130","author":"Jones","year":"2006","journal-title":"Chest"},{"key":"2025121801115582800_CIT0023","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.resuscitation.2006.08.006","article-title":"Compromising bradycardia: management in the emergency department","volume":"73","author":"Sodeck","year":"2007","journal-title":"Resuscitation"},{"key":"2025121801115582800_CIT0024","first-page":"202","article-title":"Coagulopathy by hypothermia and acidosis: mechanisms of thrombin generation and fibrinogen availability","volume":"67","author":"Martini","year":"2009","journal-title":"J Trauma"},{"issue":"4","key":"2025121801115582800_CIT0025","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1097\/01.TA.0000140480.50079.A8","article-title":"Ten year experience of burn, trauma, and combined burn\/trauma injuries comparing outcomes","volume":"57","author":"Santaniello","year":"2004","journal-title":"J Trauma"},{"key":"2025121801115582800_CIT0026","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s41038-017-0089-5","article-title":"Sepsis in the burn patient: a different problem than sepsis in the general population","volume":"5","author":"Greenhalgh","year":"2017","journal-title":"Burns Trauma"},{"key":"2025121801115582800_CIT0027","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2017-221980","article-title":"Rare postoperative complication: clostridium perfringens septic shock following elective abdominal surgery","volume":"2017","author":"Bath","year":"2017","journal-title":"BMJ Case Rep"},{"key":"2025121801115582800_CIT0028","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13023-015-0310-1","article-title":"Malignant hyperthermia: a review","volume":"10","author":"Rosenberg","year":"2015","journal-title":"Orphanet J Rare Dis"},{"key":"2025121801115582800_CIT0029","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/01.BCR.0000202644.17987.3F","article-title":"Neuroleptic malignant syndrome associated with metoclopramide in a burn patient","volume":"27","author":"Nachreiner","year":"2006","journal-title":"J Burn Care Res"},{"key":"2025121801115582800_CIT0030","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/1941875210386491","article-title":"Neuroleptic malignant syndrome: a review for neurohospitalists","volume":"1","author":"Berman","year":"2011","journal-title":"Neurohospitalist"}],"container-title":["Journal of Burn Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/irac168\/48354046\/irac168.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/article-pdf\/44\/4\/845\/50823589\/irac168.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/article-pdf\/44\/4\/845\/50823589\/irac168.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T06:12:07Z","timestamp":1766038327000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbcr\/article\/44\/4\/845\/6806178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,6]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,11,6]]},"published-print":{"date-parts":[[2023,7,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jbcr\/irac168","relation":{},"ISSN":["1559-047X","1559-0488"],"issn-type":[{"value":"1559-047X","type":"print"},{"value":"1559-0488","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,7]]},"published":{"date-parts":[[2022,11,6]]}}}