{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:01:46Z","timestamp":1791475306198,"version":"4.3.4"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Purpura fulminans (PF) is a life-threatening emergency involving coagulopathy and widespread skin necrosis. Early treatment, especially surgical management, is imperative as prognosis can be very poor. PF is most commonly associated with severe bacterial illness; however, viral causes are also possible. Currently in the literature, there have only been a handful of PF cases associated with COVID-19. We present two cases of PF in the setting of COVID-19 infection. Both patients had a history of underlying coagulopathies. PF can be a sign of underlying coagulopathy in a COVID-19 patient, who is already at increased risk for thromboembolic events due to the inflammatory nature of COVID itself. Due to how quickly PF can develop into life-threatening necrosis and multiorgan failure, it is imperative that these patients are referred early to a burn center for more advanced care.<\/jats:p>","DOI":"10.1093\/jbcr\/irac176","type":"journal-article","created":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T03:13:02Z","timestamp":1668913982000},"page":"485-486","source":"Crossref","is-referenced-by-count":5,"title":["Two Cases of COVID-19 Patients With Associated Purpura Fulminans"],"prefix":"10.1093","volume":"44","author":[{"given":"Jane","family":"Pangburn","sequence":"first","affiliation":[{"name":"Ascension St. Vincent Hospital , Indianapolis, Indiana , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Ascension St. Vincent Hospital , Indianapolis, Indiana , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,19]]},"reference":[{"key":"2023030304333873400_","article-title":"Purpura fulminans","volume-title":"StatPearls [Internet]","author":"Lavoie","year":"2022"},{"key":"2023030304333873400_","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s41038-019-0168-x","article-title":"Surgical outcomes in adults with purpura fulminans: a systematic review and patient-level meta-synthesis","volume":"7","author":"Klifto","year":"2019","journal-title":"Burns Trauma"},{"key":"2023030304333873400_","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1136\/adc.2010.199919","article-title":"Purpura fulminans: recognition, diagnosis and management","volume":"96","author":"Chalmers","year":"2011","journal-title":"Arch Dis Child"},{"key":"2023030304333873400_","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tmrv.2017.10.001","article-title":"Purpura fulminans: mechanism and management of dysregulated hemostasis","volume":"32","author":"Colling","year":"2018","journal-title":"Transfus Med Rev"},{"key":"2023030304333873400_","first-page":"e21188","article-title":"Severe acute respiratory syndrome coronavirus-2 pneumonia presenting concomitantly with purpura fulminans: a case report","volume":"14","author":"Ciprian","year":"2022","journal-title":"Cureus"},{"key":"2023030304333873400_","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/postgradmedj-2020-139202","article-title":"Purpura fulminans as the presenting manifestation of COVID-19","volume":"97","author":"Khan","year":"2021","journal-title":"Postgrad Med J"},{"key":"2023030304333873400_","article-title":"Acute infectious purpura fulminans: a rare complication of COVID-19 and acute bacterial sepsis. Abstract published at SHM Converge 2021","author":"MacKay","journal-title":"J Hosp Med"},{"key":"2023030304333873400_","doi-asserted-by":"crossref","first-page":"e109843","DOI":"10.5812\/pedinfect.109843","article-title":"Association of COVID-19 infection and purpura fulminans","volume":"9","author":"Sanaei Dashti","year":"2021","journal-title":"Arch Pediatr Infect Dis"},{"key":"2023030304333873400_","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/crj.13438","article-title":"COVID-19 and coagulopathy","volume":"15","author":"Sarkar","year":"2021","journal-title":"Clin Respir J"}],"container-title":["Journal of Burn Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/irac176\/47913710\/irac176.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/article-pdf\/44\/2\/485\/49400348\/irac176.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/article-pdf\/44\/2\/485\/49400348\/irac176.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T04:02:54Z","timestamp":1678680174000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbcr\/article\/44\/2\/485\/6834116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,19]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,11,19]]},"published-print":{"date-parts":[[2023,3,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jbcr\/irac176","relation":{},"ISSN":["1559-047X","1559-0488"],"issn-type":[{"value":"1559-047X","type":"print"},{"value":"1559-0488","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3,1]]},"published":{"date-parts":[[2022,11,19]]}}}