{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:14:53Z","timestamp":1740158093146,"version":"3.37.3"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Natural Science Grant of China","award":["82072139"],"award-info":[{"award-number":["82072139"]}]},{"name":"Fund for Distinguished Young Scholar of GDPH","award":["KJ012021184"],"award-info":[{"award-number":["KJ012021184"]}]},{"name":"High-level Hospital Construction Project of Guangdong Provincial People\u2019s Hospital","award":["KJ0122019448"],"award-info":[{"award-number":["KJ0122019448"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Purpura fulminans is a rare and rapidly progressive septic process characterized by the development of hemorrhagic and ecchymotic lesions and skin necrosis. In this work, we report a case of a 52-year-old woman admitted to the Department of Emergency due to progressive purpura. The physical examination demonstrated a decreased skin temperature, unpalpable dorsalis pedis arteries, and ecchymoses covering both lower extremities. Laboratory tests indicated disseminated intravascular coagulation with prolonged activated partial thromboplastin time (APTT), low prothrombin time (PT), elevated d-dimer levels, and a low platelet count. A diagnosis of purpura fulminans was made, and steroids, therapeutic plasma exchange and empiric therapy, including antibiotic and anticoagulation therapy, were initiated immediately. Our treatment resulted in a good and sustained clinical response, as evidenced by the receding of blood blisters and the normalization of the patient\u2019s coagulation factors, but bilateral below-knee amputation was inevitable. Finally, the patient recovered well and was discharged home without any complications other than amputation.<\/jats:p>","DOI":"10.1093\/jbcr\/irac186","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T21:34:16Z","timestamp":1671744856000},"page":"477-480","source":"Crossref","is-referenced-by-count":0,"title":["Lower Limb Necrosis Secondary to Purpura Fulminans: A Case Report"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6708-3128","authenticated-orcid":false,"given":"Chuangqiang","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China"},{"name":"Shantou University Medical College , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0246-8005","authenticated-orcid":false,"given":"Dongxin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China"},{"name":"Shantou University Medical College , China"},{"name":"The Second School of Clinical Medicine, Southern Medical University , Guangzhou , China"},{"name":"School of Medicine, South China University of Technology , Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"2023030304333713400_","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/00000441-200612000-00006","article-title":"Purpura fulminans in sepsis","volume":"332","author":"Betrosian","year":"2006","journal-title":"Am J Med Sci"},{"key":"2023030304333713400_","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tmrv.2017.10.001","article-title":"Purpura fulminans: mechanism and management of dysregulated hemostasis","volume":"32","author":"Colling","year":"2018","journal-title":"Transfus Med Rev"},{"key":"2023030304333713400_","doi-asserted-by":"crossref","first-page":"bcr2017221150","DOI":"10.1136\/bcr-2017-221150","article-title":"Purpura fulminans: a rare presentation of Streptococcus pneumoniae infection","volume":"2017","author":"Teo","year":"2017","journal-title":"BMJ Case 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