{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:34:52Z","timestamp":1791599692982,"version":"4.3.4"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"5","funder":[{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-16-2-0055"],"award-info":[{"award-number":["W81XWH-16-2-0055"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Initial fluid infusion rates for resuscitation of burn injuries typically use formulas based on patient weight and total body surface area (TBSA) burned. However, the impact of this rate on overall resuscitation volumes and outcomes have not been extensively studied. The purpose of this study was to determine the impact of initial fluid rates on 24-hour volumes and outcomes using the Burn Navigator (BN). The BN database is composed of 300 patients with \u226520% TBSA, &amp;gt;40 kg that were resuscitated utilizing the BN. Four study arms were analyzed based on the initial formula\u20142 ml\/kg\/TBSA, 3 ml\/kg\/TBSA, 4 ml\/kg\/TBSA or the Rule of Ten. Total fluids infused at 24 hours after admission were compared as well as resuscitation-related outcomes. A total of 296 patients were eligible for analysis. Higher starting rates (4 ml\/kg\/TBSA) resulted in significantly higher volumes at 24 hours (5.2 \u00b1 2.2 ml\/kg\/TBSA) than lower rates (2 ml\/kg\/TBSA resulted in 3.9 \u00b1 1.4 ml\/kg\/TBSA). No shock was observed in the high resuscitation cohort, whereas the lowest starting rate exhibited a 12% incidence, lower than both the Rule of Ten and 3 ml\/kg\/TBSA arms. There was no difference in 7-day mortality across groups. Higher initial fluid rates resulted in higher 24-hour fluid volumes. The choice of 2ml\/kg\/TBSA as initial rate did not result in increased mortality or more complications. An initial rate of 2ml\/kg\/TBSA is a safe strategy.<\/jats:p>","DOI":"10.1093\/jbcr\/irad065","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T19:06:36Z","timestamp":1687287996000},"page":"1017-1022","source":"Crossref","is-referenced-by-count":11,"title":["Higher Initial Formula for Resuscitation After Severe Burn Injury Means Higher 24-Hour Volumes"],"prefix":"10.1093","volume":"44","author":[{"given":"Julie A","family":"Rizzo","sequence":"first","affiliation":[{"name":"Brooke Army Medical Center , Fort Sam, Houston, Texas , USA"},{"name":"Uniformed Services University of Health Sciences , Bethesda, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3825-4861","authenticated-orcid":false,"given":"Elsa C","family":"Coates","sequence":"additional","affiliation":[{"name":"United States Army Institute of Surgical Research , Fort Sam, Houston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L","family":"Serio-Melvin","sequence":"additional","affiliation":[{"name":"United States Army Institute of Surgical Research , Fort Sam, Houston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9365-4983","authenticated-orcid":false,"given":"James K","family":"Aden","sequence":"additional","affiliation":[{"name":"Brooke Army Medical Center , Fort Sam, Houston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D","family":"Stallings","sequence":"additional","affiliation":[{"name":"Brooke Army Medical Center , Fort Sam, Houston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin N","family":"Foster","sequence":"additional","affiliation":[{"name":"Arizona Burn Center Valleywise Health , Phoenix, Arizona , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareem R","family":"Abdel Fattah","sequence":"additional","affiliation":[{"name":"UT-Southwestern Medical Center , Dallas, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5231-7745","authenticated-orcid":false,"given":"Tam N","family":"Pham","sequence":"additional","affiliation":[{"name":"UW Medicine Regional Burn Center, Harborview Medical Center , Seattle WA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Salinas","sequence":"additional","affiliation":[{"name":"United States Army Institute of Surgical Research , Fort Sam, Houston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,20]]},"reference":[{"key":"2023090710051398400_CIT0001","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/00005373-200009000-00030","article-title":"Protection from excessive resuscitation: \u201cpushing the pendulum 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