{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:25:18Z","timestamp":1758475518802,"version":"3.37.3"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Patients with Stevens\u2013Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have traditionally been treated in burn centers. Our burn center\u2019s approach differs by admitting these patients to a medicine service, with support from the burn team. The aim of this study was to determine whether SJS\/TEN patients cared for with our system, with burn involvement but not burn admission, demonstrate equivalent outcomes. We conducted a retrospective review of all SJS\/TEN patients admitted to the medicine service at a single academic medical center from 2009 to 2021. Outcome measures such as mortality, length of ICU stay, and total length of hospitalization were collected. The Severity-of-Illness Score for Toxic Epidermal Necrolysis (SCORTEN) was used to calculate expected mortality rates within the cohort. The observed mortality rates were then compared to the expected mortality rates. One hundred and twenty-six patients who were admitted for SJS\/TEN were included (70 SJS, 40 SJS\/TEN overlap, 16 TEN). The mortality rate for the entire cohort was 10.32% as compared to a 22.33% expected mortality rate (P = .010). The observed and expected mortality rates for SJS, SJS\/TEN overlap, and TEN subgroups were 1.43% observed versus 10.22% expected (P = .029), 20.00% observed versus 35.83% expected (P = .133), and 25.00% observed version 44.06% expected (P = .264), respectively. Mortality rates in SJS\/TEN patients admitted to medicine units are equivalent or decreased as compared to SCORTEN-predicted mortality rates. Admission of SJS\/TEN patients to a medicine unit is appropriate providing there is burn team involvement in their care.<\/jats:p>","DOI":"10.1093\/jbcr\/irad137","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T11:33:18Z","timestamp":1694518398000},"page":"165-168","source":"Crossref","is-referenced-by-count":2,"title":["Outcomes in Stevens\u2013Johnson Syndrome\/Toxic Epidermal Necrolysis Patients Treated With a Medicine-Led Multidisciplinary Approach"],"prefix":"10.1093","volume":"45","author":[{"given":"Joseph A","family":"Lewcun","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Virginia Commonwealth University Health System , Richmond, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7003-4683","authenticated-orcid":false,"given":"Alex","family":"Vagonis","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Virginia Commonwealth University Health System , Richmond, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Kontzias","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Virginia Commonwealth University Health System , Richmond, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Newsom","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Virginia Commonwealth University Health System , Richmond, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mack","family":"Drake","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Virginia Commonwealth University Health System , Richmond, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J","family":"Feldman","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Virginia Commonwealth University Health System , Richmond, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"issue":"1","key":"2024012012011128400_CIT0001","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1001\/archderm.1993.01680220104023","article-title":"Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme","volume":"129","author":"Bastuji-Garin","year":"1993","journal-title":"Arch Dermatol"},{"key":"2024012012011128400_CIT0002","first-page":"1160","article-title":"Toxic epidermal necrolysis. Clinical findings and prognosis factors in 87 patients","volume-title":"Arch Dermatol","author":"Revuz","year":"1987"},{"key":"2024012012011128400_CIT0003","first-page":"60","article-title":"ALDEN, an algorithm for assessment of drug causality in Stevens-Johnson Syndrome and toxic epidermal necrolysis: comparison with case-control analysis","volume-title":"Clin Pharmacol Ther","author":"Sassolas","year":"2010"},{"key":"2024012012011128400_CIT0004","first-page":"323","article-title":"Toxic epidermal necrolysis and Stevens-Johnson syndrome: does early withdrawal of causative drugs decrease the risk of death","volume-title":"Arch Dermatol","author":"Garcia-Doval","year":"2000"},{"key":"2024012012011128400_CIT0005","first-page":"1235","article-title":"Stevens-Johnson syndrome and toxic epidermal necrolysis: a concise review with a comprehensive summary of therapeutic interventions emphasizing supportive measures","volume-title":"Adv Ther","author":"Schneider","year":"2017"},{"key":"2024012012011128400_CIT0006","first-page":"1152","article-title":"Antishear therapy for Stevens-Johnson syndrome and toxic epidermal necrolysis: a follow-up study","volume-title":"J Burn Care Res","author":"Haravu","year":"2021"},{"key":"2024012012011128400_CIT0007","first-page":"CD013130","article-title":"Systemic interventions for treatment of Stevens\u2013Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS\/TEN overlap syndrome","volume-title":"Cochrane Database Syst Rev","author":"Jacobsen","year":"2022"},{"key":"2024012012011128400_CIT0008","first-page":"1197","article-title":"Comprehensive survival analysis of a cohort of patients with Stevens-Johnson syndrome and toxic epidermal necrolysis","volume-title":"J Invest Dermatol","author":"Sekula","year":"2013"},{"key":"2024012012011128400_CIT0009","first-page":"1194","article-title":"U.K. guidelines for the management of Stevens-Johnson syndrome\/toxic epidermal necrolysis in adults 2016","volume-title":"Br J Dermatol","author":"Creamer","year":"2016"},{"key":"2024012012011128400_CIT0010","first-page":"87","article-title":"A multicenter review of toxic epidermal necrolysis treated in U.S. burn centers at the end of the twentieth century","volume-title":"J Burn Care Rehabil","author":"Palmieri","year":"2002"}],"container-title":["Journal of Burn Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/irad137\/51709052\/irad137.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/article-pdf\/45\/1\/165\/56258543\/irad137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/article-pdf\/45\/1\/165\/56258543\/irad137.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T12:01:41Z","timestamp":1705752101000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbcr\/article\/45\/1\/165\/7271138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,12]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,9,12]]},"published-print":{"date-parts":[[2024,1,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jbcr\/irad137","relation":{},"ISSN":["1559-047X","1559-0488"],"issn-type":[{"type":"print","value":"1559-047X"},{"type":"electronic","value":"1559-0488"}],"subject":[],"published-other":{"date-parts":[[2024,1,1]]},"published":{"date-parts":[[2023,9,12]]}}}