{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:56:43Z","timestamp":1778511403316,"version":"3.51.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T00:00:00Z","timestamp":1697241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Systems Biology Coagulopathy of Trauma"},{"name":"Defense Health Program","award":["W911NF-10-1-03761"],"award-info":[{"award-number":["W911NF-10-1-03761"]}]},{"name":"Defense Health Program","award":["W911QY-15-C-0025"],"award-info":[{"award-number":["W911QY-15-C-0025"]}]},{"name":"Defense Health Program","award":["W911QY-15-C-0027"],"award-info":[{"award-number":["W911QY-15-C-0027"]}]},{"name":"Defense Health Program","award":["W911QY-15-C-0044"],"award-info":[{"award-number":["W911QY-15-C-0044"]}]},{"name":"Defense Health Program","award":["W911QY-15-C-0026"],"award-info":[{"award-number":["W911QY-15-C-0026"]}]},{"DOI":"10.13039\/100016156","name":"U.S. Army Medical Research and Development Command","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although use of thromboelastography (TEG) to diagnose coagulopathy and guide clinical decision-making is increasing, relative performance of different TEG methods has not been well-defined. Rapid-TEG (rTEG), kaolin-TEG (kTEG), and native-TEG (nTEG) were performed on blood samples from burn patients presenting to a regional center from admission to 21 days. Patients were categorized by burn severity, mortality, and fibrinolytic phenotypes (Shutdown [SD], Physiologic [PHYS], and Hyperfibrinolytic [HF]). Manufacturer ranges and published TEG cutoffs were examined. Concordance correlations (Rc) of TEG parameters (R, \u03b1-angle, maximum amplitude [MA], LY30) measured agreement and Cohen\u2019s Kappa (\u03ba) determined interclass reliability. Patients (n = 121) were mostly male (n = 84; 69.4%), with median age 40 years, median TBSA burn 13%, and mortality 17% (n = 21). Severe burns (\u226540% TBSA) were associated with lower admission \u03b1-angle for rTEG (P = .03) and lower MA for rTEG (P = .02) and kTEG (P = .01). MA was lower in patients who died (nTEG, P = .04; kTEG, P = .02; rTEG, P = .003). Admission HF was associated with increased mortality (OR, 10.45; 95% CI, 2.54\u201343.31, P = .001) on rTEG only. Delayed SD was associated with mortality using rTEG and nTEG (OR 9.46; 95% CI, 1.96\u201345.73; P = .005 and OR, 6.91; 95% CI, 1.35\u201335.48; P = .02). Admission TEGs showed poor agreement on R-time (Rc, 0.00\u20130.56) and \u03b1-angle (0.40 to 0.55), and moderate agreement on MA (0.67\u20130.81) and LY30 (0.72\u20130.93). Interclass reliability was lowest for R-time (\u03ba, \u22120.07 to 0.01) and \u03b1-angle (\u22120.06 to 0.17) and highest for MA (0.22-0.51) and LY30 (0.29-0.49). Choice of TEG method may impact clinical decision-making. rTEG appeared most sensitive in parameter-specific associations with injury severity, abnormal fibrinolysis, and mortality.<\/jats:p>","DOI":"10.1093\/jbcr\/irad152","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:30:42Z","timestamp":1697232642000},"page":"70-79","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of Rapid-, Kaolin-, and Native-TEG Parameters in Burn Patient Cohorts With Acute Burn-induced Coagulopathy and Abnormal Fibrinolytic Function"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9540-2664","authenticated-orcid":false,"given":"John W","family":"Keyloun","sequence":"first","affiliation":[{"name":"The Burn Center, Department of Surgery, MedStar Washington Hospital Center , Washington, DC 20010 , USA"},{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute , Washington, DC 20010 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1539-6346","authenticated-orcid":false,"given":"Tuan D","family":"Le","sequence":"additional","affiliation":[{"name":"Research Directorate, U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston , TX 78234 , USA"},{"name":"Department of Epidemiology and Biostatistics, University of Texas Tyler School of Medicine , Tyler, TX 75708 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren T","family":"Moffatt","sequence":"additional","affiliation":[{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute , Washington, DC 20010 , USA"},{"name":"Department of Biochemistry, Georgetown University , Washington, DC 20057 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Orfeo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, University of Vermont , Colchester, VT 05405 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7400-2509","authenticated-orcid":false,"given":"Melissa M","family":"McLawhorn","sequence":"additional","affiliation":[{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute , Washington, DC 20010 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Cristina","family":"Bravo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, University of Vermont , Colchester, VT 05405 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn","family":"Tejiram","sequence":"additional","affiliation":[{"name":"The Burn Center, Department of Surgery, MedStar Washington Hospital Center , Washington, DC 20010 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the SYSCOT Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Cristina","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen E","family":"Brummel-Ziedins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael A","family":"Callcut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell J","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalev","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aarti","family":"Gautam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha","family":"Hammamieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marti","family":"Jett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa M","family":"McLawhorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren T","family":"Moffatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1324-4835","authenticated-orcid":false,"given":"Anthony E","family":"Pusateri","sequence":"additional","affiliation":[{"name":"Combat Casualty Care and Operational Medicine Directorate, Naval Medical Research Unit San Antonio, JBSA Fort Sam Houston , TX 78234 , USA"},{"name":"Department of Surgery, Uniformed Services University of Health Sciences , Bethesda, MD 20814 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,14]]},"reference":[{"key":"2024012012010986400_CIT0001","first-page":"345","article-title":"Admission Rapid Thrombelastography (rTEG\u00ae) values predict resuscitation volumes and patient outcomes after thermal injury","volume-title":"J Burn Care Res","author":"Huzar","year":"2018"},{"key":"2024012012010986400_CIT0002","first-page":"544","article-title":"Incidence and prognostic value of acute coagulopathy 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