{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:24:36Z","timestamp":1787009076048,"version":"build-2736575974"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This case series reviews the management of 2 patients who developed a rare, aggressive soft tissue infection, necrotizing fasciitis treated with a synthetic polyurethane dermal regenerative template, Biodegradable Temporizing Matrix (NovoSorb BTM) in conjunction with an off-label use of RECELL device applying autologous skin cell suspension and a split-thickness skin graft for reconstruction. The clinical relevance describes a non-traditional patient\u2019s course of treatment and clinical outcome using BTM and RECELL for necrotizing fasciitis. The 2 patients survived with acceptable outcomes and timely healing despite a high chance of mortality and likely amputation secondary to the extensive surface area and anatomical location of the infection.<\/jats:p>","DOI":"10.1093\/jbcr\/irad192","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T15:26:59Z","timestamp":1702394819000},"page":"528-532","source":"Crossref","is-referenced-by-count":6,"title":["Treatment of Necrotizing Fasciitis With NovoSorb Biodegradable Temporizing Matrix and RECELL Autologous Skin Cell Suspension: A Case Series"],"prefix":"10.1093","volume":"45","author":[{"given":"Cindy L","family":"Austin","sequence":"first","affiliation":[{"name":"Mercy Hospital\u2014Springfield, Trauma & Burn Research , 1235 E Cherokee, 5H, Springfield, MO 65804 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwafolaranmi E","family":"Sodade","sequence":"additional","affiliation":[{"name":"Mercy Hospital\u2014Springfield, Trauma & Burn Research , 1235 E Cherokee, 5H, Springfield, MO 65804 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brody","family":"Harrison","sequence":"additional","affiliation":[{"name":"Mercy Hospital\u2014Springfield, Department of Burn , 1235 E Cherokee, 7H, Springfield, MO 65804 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisi","family":"Causa","sequence":"additional","affiliation":[{"name":"Mercy Hospital\u2014Springfield, Trauma and Burn Surgery , 1965 S Fremont Ave, Springfield, MO 65804 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"2024030419494878700_CIT0001","author":"Centers for Disease Control and Prevention"},{"issue":"1","key":"2024030419494878700_CIT0002","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1186\/s12879-021-06928-5","article-title":"Incidence and mortality of necrotizing fasciitis in the Netherlands: impact of group A Streptococcus","volume":"21","author":"Nawiin","year":"2021","journal-title":"BMC Inf Dis"},{"key":"2024030419494878700_CIT0003","author":"PolyNovo NovoSorb BTM Product"},{"key":"2024030419494878700_CIT0004","article-title":"Acute thermal burn and full-thickness skin defects ISI. Indications for use. Autologous Therapy for Treating Thermal Burn Wounds | RECELL\u00ae System","author":"RECELL Safety Information"},{"issue":"13","key":"2024030419494878700_CIT0005","first-page":"102","article-title":"A biodegradable polyurethane dermal matrix in reconstruction of free flap donor sites: a pilot study","volume":"15","author":"Wagstaff","year":"2015","journal-title":"Eplasty"},{"issue":"1","key":"2024030419494878700_CIT0006","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.burnso.2017.08.001","article-title":"Experience with a synthetic bilayer Biodegradable Temporising Matrix in significant burn injury","volume":"2","author":"Greenwood","year":"2018","journal-title":"Burns Open"},{"issue":"1","key":"2024030419494878700_CIT0007","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/jbcr\/irz179","article-title":"Treatment of a full-thickness burn injury with NovoSorb Biodegradable Temporizing Matrix and RECELL autologous skin cell suspension: a case series","volume":"41","author":"Larson","year":"2020","journal-title":"J Burn Care Res"},{"issue":"1","key":"2024030419494878700_CIT0008","doi-asserted-by":"crossref","first-page":"106","DOI":"10.34239\/ajops.v2i1.72","article-title":"Biodegradable temporizing matrix for necrotizing soft tissue infections: a case report","volume":"2","author":"Sreedharan","year":"2019","journal-title":"Austral J Plastic Surg"},{"key":"2024030419494878700_CIT0009","first-page":"12","article-title":"Biodegradable Temporizing Matrix for reconstruction of defect following serial debridement for necrotizing fasciitis: a case series","volume-title":"Burns Open","author":"Wagstaff","year":"2019"},{"key":"2024030419494878700_CIT0010","first-page":"e4197","article-title":"Autologous cell harvesting system as adjunct for soft-tissue reconstruction of necrotizing soft tissue infection","volume-title":"Plast Reconstr Surg Glob Open","author":"Collins","year":"2022"},{"key":"2024030419494878700_CIT0011","first-page":"S175","article-title":"Biodegradable Temporizing Matrix in combination with wide meshed graft and autologous spray cell suspension graft can be used for reconstruction of extensive necrotizing infections: a case report","volume-title":"J Burn Care Res","author":"Olivi","year":"2021"},{"issue":"5","key":"2024030419494878700_CIT0012","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1093\/jbcr\/irab073","article-title":"Biodegradable Temporizing Matrix reconstruction of complex perineal burn wound","volume":"42","author":"Concannon","year":"2021","journal-title":"J Burn Care Res"},{"issue":"3","key":"2024030419494878700_CIT0013","doi-asserted-by":"crossref","first-page":"159","DOI":"10.12968\/jowc.2023.32.3.159","article-title":"Biodegradable temporizing matrix: use of negative pressure wound therapy shows a significantly higher success rate","volume":"32","author":"Larson","year":"2023","journal-title":"J Wound Care"},{"key":"2024030419494878700_CIT0014","article-title":"What is necrotizing fasciitis","author":"Flesh Eating Bacteria"},{"key":"2024030419494878700_CIT0015","first-page":"1","article-title":"Review of 58 patients with necrotizing fasciitis in the Netherlands","volume-title":"World J Emerg Surg","author":"Van Stigt","year":"2016"},{"key":"2024030419494878700_CIT0016","first-page":"772","article-title":"Demonstration of the safety and effectiveness of the RECELL System combined with split-thickness meshed autografts for the reduction of donor skin to treat mixed-depth burn injuries","volume-title":"Burns","author":"Holmes","year":"2019"},{"key":"2024030419494878700_CIT0017","article-title":"RECELL Autologous Cell Harvesting Device","author":"U.S. Food and Drug Administration"}],"container-title":["Journal of Burn Care &amp; 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