{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:50:20Z","timestamp":1786683020659,"version":"build-2736575974"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Commission H2020 SME"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Partial-thickness burns are the most common form of burns, affecting the dermis and possibly resulting in scarring and infection. The Spincare System is a new device that uses electrospinning technology to create a temporary skin-like matrix that can be applied to wounds. This study evaluated the performance, safety, and efficacy of Spincare in treating superficial to partial-thickness burns not considered for surgery. A prospective single-arm, open-label, multicenter study was conducted in 3 adult burn units across Israel. Forty-four patients with superficial to intermediate burns of up to 10% of TBSA were enrolled. Spincare was applied to the wounds, and follow-up visits were performed on days 7, 14, and 21 and months 3 and 6 posttreatment. Thirty-one patients with 36 wounds completed the day 21 visit. The mean wound healing area on day 21 was 97.26 \u00b1 9.41%, and the mean healing time was 12.8 \u00b1 4.3 days. Only one moderate adverse event was observed concerning the treatment, and it is important to acknowledge the potential progression of this hypertrophic scar into a keloid. This study demonstrated that Spincare is a safe and effective device for treating superficial to intermediate partial-thickness burns. Spincare achieved rapid and complete wound healing with a low incidence of adverse events.<\/jats:p>","DOI":"10.1093\/jbcr\/irae024","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T05:59:15Z","timestamp":1708408755000},"page":"969-977","source":"Crossref","is-referenced-by-count":8,"title":["Spincare System Demonstrates Safety and Efficacy in Treating Partial-Thickness Burns"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2939-0324","authenticated-orcid":false,"given":"Josef","family":"Haik","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Ramat-Gan, affiliated with the School of Medicine, Tel-Aviv University , Tel-Aviv, 52621 , Israel"},{"name":"Talpiot Leadership Program, Sheba Medical Center , Tel-Hashomer , Israel"},{"name":"Institute for Health Research, University of Notre Dame , Fremantle, 6160, WA , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Ullmann","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Rambam Health Care Campus, affiliated with the Rappaport Faculty of Medicine , Technion, Haifa, 3109601 , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Gur","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Sourasky Medical Center, affiliated with the School of Medicine, Tel-Aviv University , Tel-Aviv, 6423906 , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1154-5367","authenticated-orcid":false,"given":"Erik","family":"Biros","sequence":"additional","affiliation":[{"name":"College of Medicine and Dentistry, James Cook University , Townsville, 4810 , Australia"},{"name":"Townville University Hospital , Townsville,4810 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Kornhaber","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Ramat-Gan, affiliated with the School of Medicine, Tel-Aviv University , Tel-Aviv, 52621 , Israel"},{"name":"School of Nursing, Paramedicine and Healthcare Sciences, Charles Sturt University , Bathurst, NSW, 2795 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1453-4850","authenticated-orcid":false,"given":"Michelle","family":"Cleary","sequence":"additional","affiliation":[{"name":"School of Nursing, Midwifery and Social Sciences, CQUniversity , Sydeney, NSW, 2000 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani","family":"Kruchevsky","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Rambam Health Care Campus, affiliated with the Rappaport Faculty of Medicine , Technion, Haifa, 3109601 , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivan","family":"Zissman","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Sourasky Medical Center, affiliated with the School of Medicine, Tel-Aviv University , Tel-Aviv, 6423906 , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yossi","family":"Namir","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Sourasky Medical Center, affiliated with the School of Medicine, Tel-Aviv University , Tel-Aviv, 6423906 , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-0887","authenticated-orcid":false,"given":"Moti","family":"Harats","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Ramat-Gan, affiliated with the School of Medicine, Tel-Aviv University , Tel-Aviv, 52621 , Israel"},{"name":"Talpiot Leadership Program, Sheba Medical Center , Tel-Hashomer , Israel"},{"name":"Institute for Health Research, University of Notre Dame , Fremantle, 6160, WA , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"issue":"6","key":"2024080703314183300_CIT0001","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1097\/BCR.0b013e3181599b88","article-title":"Results of an internet survey on the treatment of partial thickness burns, full thickness burns, and donor sites","volume":"28","author":"Hermans","year":"2007","journal-title":"J Burn Care Res"},{"key":"2024080703314183300_CIT0002","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s13054-015-0961-2","article-title":"Burn wound healing and treatment: review and advancements","volume":"19","author":"Rowan","year":"2015","journal-title":"Crit Care"},{"issue":"1","key":"2024080703314183300_CIT0003","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.medin.2015.11.010","article-title":"Initial evaluation and management of the critical burn patient","volume":"40","author":"Vivo","year":"2016","journal-title":"Med Intensiva"},{"issue":"3","key":"2024080703314183300_CIT0004","doi-asserted-by":"crossref","first-page":"e605","DOI":"10.1097\/BCR.0000000000000538","article-title":"Burn wound healing and tissue engineering","volume":"38","author":"Singer","year":"2017","journal-title":"J Burn Care Res"},{"issue":"15","key":"2024080703314183300_CIT0005","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.3390\/cells11152439","article-title":"Innovative treatment strategies to accelerate wound healing: trajectory and recent advancements","volume":"11","author":"Kolimi","year":"2022","journal-title":"Cells"},{"issue":"1","key":"2024080703314183300_CIT0006","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/ebj4010004","article-title":"Smart polymeric wound dressing for treating partial-thickness burns: a preliminary preclinical study on the porcine model","volume":"4","author":"Beylin","year":"2023","journal-title":"Eur Burn J"},{"issue":"8","key":"2024080703314183300_CIT0007","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3390\/pharmaceutics12080735","article-title":"Skin wound healing process and new emerging technologies for skin wound care and regeneration","volume":"12","author":"Tottoli","year":"2020","journal-title":"Pharmaceutics"},{"issue":"5","key":"2024080703314183300_CIT0008","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1089\/wound.2016.0722","article-title":"The feasibility of a handheld electrospinning device for the application of nanofibrous wound dressings","volume":"6","author":"Haik","year":"2017","journal-title":"Adv Wound Care"},{"issue":"4","key":"2024080703314183300_CIT0009","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/jbcr\/irab216","article-title":"Advances in the use of electrospun nanofibrous polymeric matrix for dermal healing at the donor site after the split-thickness skin graft excision: a prospective, randomized, controlled, open-label, multicenter study","volume":"43","author":"Haik","year":"2021","journal-title":"J Burn Care Res"},{"issue":"3","key":"2024080703314183300_CIT0010","first-page":"480","article-title":"Irritantcy potential and sub acute dermal toxicity study of Pistacia lentiscus fatty oil as a topical traditional remedy","volume":"10","author":"Djerrou","year":"2013","journal-title":"Afr J Tradit Complement Altern Med"},{"issue":"4","key":"2024080703314183300_CIT0011","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.burns.2020.08.008","article-title":"A bio-degradable synthetic membrane to treat superficial and deep second degree burn wounds in adults and children\u20144 year experience","volume":"47","author":"Blome-Eberwein","year":"2021","journal-title":"Burns"},{"issue":"1","key":"2024080703314183300_CIT0012","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.burns.2012.05.005","article-title":"Use of Suprathel(R) for partial thickness burns in children","volume":"39","author":"Highton","year":"2013","journal-title":"Burns"},{"issue":"1","key":"2024080703314183300_CIT0013","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/iwj.12853","article-title":"A randomised, controlled, non-inferiority trial comparing the performance of a soft silicone-coated wound contact layer (Mepitel One) with a lipidocolloid wound contact layer (UrgoTul) in the treatment of acute wounds","volume":"15","author":"David","year":"2018","journal-title":"Int Wound J"},{"key":"2024080703314183300_CIT0014","volume-title":"Hypertrophic Scarring Keloids. StatPearls","author":"Carswell","year":"2022"},{"key":"2024080703314183300_CIT0015","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jpra.2019.09.004","article-title":"Keloid pathophysiology: fibroblast or inflammatory disorders","volume":"22","author":"Nangole","year":"2019","journal-title":"JPRAS Open"},{"issue":"2","key":"2024080703314183300_CIT0016","first-page":"80","article-title":"Non-operative treatment of hypertrophic scars and keloids after burns in children","volume":"19","author":"Argirova","year":"2006","journal-title":"Ann Burns Fire Disasters"},{"issue":"1","key":"2024080703314183300_CIT0017","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12895-016-0050-5","article-title":"Risk factors of keloids in Syrians","volume":"16","author":"Shaheen","year":"2016","journal-title":"BMC Dermatol"},{"issue":"9","key":"2024080703314183300_CIT0018","doi-asserted-by":"crossref","first-page":"e234","DOI":"10.1371\/journal.pmed.0040234","article-title":"Hypertrophic scar formation following burns and trauma: new approaches to treatment","volume":"4","author":"Aarabi","year":"2007","journal-title":"PLoS Med"}],"container-title":["Journal of Burn Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/irae024\/56824988\/irae024.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/article-pdf\/45\/4\/969\/58749260\/irae024.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/article-pdf\/45\/4\/969\/58749260\/irae024.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T04:42:27Z","timestamp":1723005747000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbcr\/article\/45\/4\/969\/7611959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,21]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,2,21]]},"published-print":{"date-parts":[[2024,8,6]]}},"URL":"https:\/\/doi.org\/10.1093\/jbcr\/irae024","relation":{},"ISSN":["1559-047X","1559-0488"],"issn-type":[{"value":"1559-047X","type":"print"},{"value":"1559-0488","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,2,21]]}}}