{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:39:32Z","timestamp":1787063972952,"version":"build-2736575974"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shionogi, Inc.","award":["22-0113-230683"],"award-info":[{"award-number":["22-0113-230683"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pyoderma gangrenosum is a rare dermatologic disorder that disrupts the skin barrier, requiring immunosuppressive therapy. We successfully used cefiderocol for the treatment of an extensively drug-resistant Pseudomonas aeruginosa bacteremia, and presumed osteomyelitis in a patient with severe pyoderma gangrenosum and associated immunosuppressive therapy while being medically optimized for skin grafting. We obtained bone and skin\/subcutaneous tissue while the patient was on cefiderocol under an institutional review board-approved biologic waste recovery protocol. Cefiderocol concentrations in bone and skin\/subcutaneous tissue were 13.9 and 35.9 mcg\/g, respectively. The patient recovered from bacteremia and underwent autografting without further complications. Cefiderocol at approved dosing of 2 g IV (3-hour infusion) every 8 hours resulted in bone and skin\/subcutaneous tissue concentrations adequate to treat extensively drug-resistant Gram-negative bacteria that remain susceptible to cefiderocol.<\/jats:p>","DOI":"10.1093\/jbcr\/irae026","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T18:09:58Z","timestamp":1709143798000},"page":"808-810","source":"Crossref","is-referenced-by-count":8,"title":["Bone and Skin\/Subcutaneous Tissue Concentrations of Cefiderocol During Treatment of Extensively Drug-Resistant\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1093","volume":"45","author":[{"given":"Scott W","family":"Mueller","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Colorado Hospital , Aurora, CO 80045 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle C","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Colorado Anschutz School of Medicine , Aurora, CO 80045 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Blass","sequence":"additional","affiliation":[{"name":"Division of GI, Trauma, and Endocrine Surgery (GITES), Department of Surgery, University of Colorado Hospital , Aurora, CO 80045 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7776-0268","authenticated-orcid":false,"given":"Cameron","family":"Gibson","sequence":"additional","affiliation":[{"name":"Division of GI, Trauma, and Endocrine Surgery (GITES), Department of Surgery, University of Colorado Hospital , Aurora, CO 80045 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber D","family":"Kohler","sequence":"additional","affiliation":[{"name":"Division of GI, Trauma, and Endocrine Surgery (GITES), Department of Surgery, University of Colorado Hospital , Aurora, CO 80045 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1746-7462","authenticated-orcid":false,"given":"Martin","family":"Krsak","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Colorado School of Medicine , Aurora, CO 80045 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arek J","family":"Wiktor","sequence":"additional","affiliation":[{"name":"Division of GI, Trauma, and Endocrine Surgery (GITES), Department of Surgery, University of Colorado Hospital , Aurora, CO 80045 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"issue":"1","key":"2024050616493807200_CIT0001","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41572-020-0213-x","article-title":"Pyoderma 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