{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T01:06:59Z","timestamp":1768352819679,"version":"3.49.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Inhalation injury is a major risk factor for mortality in burn patients via 3 primary mechanisms: airway edema and obstruction, hypoxemic respiratory failure, and pneumonia. Currently, the mainstay of treatment is supportive care to include early intubation, lung-protective or high-frequency-percussive mechanical ventilation, nebulized heparin, and aggressive pulmonary toilet. Despite these treatments, a subset of these patients progress to severe acute respiratory distress syndrome (ARDS) for which rescue options are limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case Presentation<\/jats:title>\n                  <jats:p>A 31-year-old woman was found down in a house fire. On admission to the burn intensive care unit, she was diagnosed with grade 3 smoke inhalation injury. Cutaneous thermal injury was absent. By hospital day 2, she developed worsening hypoxemia and hypercapnia despite maximal ventilatory support. She was placed on veno-venous extracorporeal membrane oxygenation (ECMO). She received an average of 2.2 hours of direct rehabilitation a day and completed out-of-bed modalities over 90% of total hospital days. After 159 hours, she was decannulated, and by hospital day 18, she was discharged home on supplemental oxygen.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Current literature regarding ECMO in inhalation injury is limited, but a growing body of evidence suggests that treatment of severe smoke inhalation injury should include ECMO for those who fail conventional therapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jbcr\/irae027","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T21:54:38Z","timestamp":1708034078000},"page":"796-800","source":"Crossref","is-referenced-by-count":4,"title":["Extracorporeal Membrane Oxygenation in a Patient with Severe Inhalation Injury: Multidisciplinary Burn Team Care"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8041-440X","authenticated-orcid":false,"given":"Rachael A","family":"Peters","sequence":"first","affiliation":[{"name":"School of Medicine, Uniformed Services University of the Health Sciences , Bethesda, MD 20814 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5890-3048","authenticated-orcid":false,"given":"Jill M","family":"Cancio","sequence":"additional","affiliation":[{"name":"U.S. Army Institute of Surgical Research , Fort Sam Houston, San Antonio, TX 78234 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Glenn","sequence":"additional","affiliation":[{"name":"Infectious Disease and Critical Care, San Antonio Military Medical Center , Fort Sam Houston, San Antonio, TX 78234 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0066-1998","authenticated-orcid":false,"given":"Leopoldo C","family":"Cancio","sequence":"additional","affiliation":[{"name":"U.S. Army Institute of Surgical Research , Fort Sam Houston, San Antonio, TX 78234 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"2024050616493838500_CIT0001","first-page":"5","article-title":"Extracorporeal membrane oxygenation for COVID-19-related acute respiratory distress syndrome: a narrative review","volume-title":"J Intensive Care","author":"Alessandri","year":"2023"},{"key":"2024050616493838500_CIT0002","first-page":"23","article-title":"Basics of extracorporeal membrane oxygenation","volume-title":"Surg Clin North Am","author":"Wrisinger","year":"2022"},{"key":"2024050616493838500_CIT0003","first-page":"62","article-title":"Successful management of adult smoke inhalation with extracorporeal membrane oxygenation","volume-title":"J Burn Care Rehabil","author":"Thompson","year":"2005"},{"key":"2024050616493838500_CIT0004","first-page":"475","article-title":"Prolonged airway and systemic inflammatory reactions after smoke inhalation","volume-title":"Chest","author":"Park","year":"2003"},{"issue":"1","key":"2024050616493838500_CIT0005","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/00000658-198701000-00015","article-title":"The influence of inhalation injury and pneumonia on burn mortality","volume":"205","author":"Shirani","year":"1987","journal-title":"Ann Surg"},{"key":"2024050616493838500_CIT0006","first-page":"1970","article-title":"High-frequency percussive ventilation and low tidal volume ventilation in burns: a randomized controlled trial","volume-title":"Crit Care Med","author":"Chung","year":"2010"},{"key":"2024050616493838500_CIT0007","first-page":"575","article-title":"Prophylactic use of high-frequency percussive ventilation in patients with inhalation injury","volume-title":"Ann Surg","author":"Cioffi","year":"1991"},{"key":"2024050616493838500_CIT0008","first-page":"31","article-title":"Inhalation injury: epidemiology, pathology, treatment strategies","volume-title":"Scand J Trauma Resusc Emerg Med","author":"Dries","year":"2013"},{"key":"2024050616493838500_CIT0009","first-page":"216","article-title":"Early rehabilitation in the intensive care unit: an integrative literature review","volume-title":"Aust Crit Care","author":"Sosnowski","year":"2015"},{"key":"2024050616493838500_CIT0010","first-page":"351","article-title":"Diagnosis and management of inhalation injury: an updated review","volume-title":"Crit Care","author":"Walker","year":"2015"},{"key":"2024050616493838500_CIT0011","first-page":"1091","article-title":"Extracorporeal membrane oxygenation in severe respiratory failure resulting from burns and smoke inhalation injury","volume-title":"Burns","author":"Szentgyorgyi","year":"2018"},{"key":"2024050616493838500_CIT0012","first-page":"2314","article-title":"Comparison of airway pressure release ventilation to conventional mechanical ventilation in the early management of smoke inhalation injury in swine","volume-title":"Crit Care Med","author":"Batchinsky","year":"2011"},{"key":"2024050616493838500_CIT0013","first-page":"601","article-title":"Management of adult patients supported with venovenous extracorporeal membrane oxygenation (VV ECMO): guideline from the Extracorporeal Life Support Organization (ELSO)","volume-title":"ASAIO J","author":"Tonna","year":"2021"},{"key":"2024050616493838500_CIT0014","first-page":"429","article-title":"Extracorporeal membrane oxygenation in burn and smoke inhalation injury","volume-title":"Burns","author":"Asmussen","year":"2013"},{"key":"2024050616493838500_CIT0015","first-page":"1433","article-title":"Revisiting extracorporeal membrane oxygenation for ARDS in burns: a case series and review of the literature","volume-title":"Burns","author":"Ainsworth","year":"2018"},{"key":"2024050616493838500_CIT0016","first-page":"10","article-title":"A national perspective on ECMO utilization use in patients with burn injury","volume-title":"J Burn Care Res","author":"Nosanov","year":"2017"},{"key":"2024050616493838500_CIT0017","first-page":"227","article-title":"Safety and potential benefits of physical therapy in adult patients on extracorporeal membrane oxygenation support: a systematic review","volume-title":"Rev Bras Ter Intensiva","author":"Ferreira","year":"2019"}],"container-title":["Journal of Burn Care &amp; 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